Experimental and Therapeutic Targeting of Heme Oxygenase
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: closed (30 May 2024) | Viewed by 21057
Special Issue Editor
Interests: heme oxygenase in cell and organ dysfunction; heme oxygenase and biliverdin reductase activity; ferroptosis; oxidative stress response
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heme oxygenase (HO) is an integral part of antioxidative cellular defense. HO catalyzes the rate-limiting step of heme degradation, yielding carbon monoxide (CO), ferrous iron (Fe2+), and biliverdin, which is further reduced to bilirubin in mammalians. Mammalian heme oxygenase exists in two catalytically active isoforms: the inducible isoform HO-1, and the constitutively expressed isoform HO-2. Both enzymes contribute to a different extent to the overall HO activity, which is capable of exerting cytoprotection via two synergistic effects: the removal of pro-oxidative heme and the generation of HO products, CO and biliverdin/bilirubin with antioxidative, antiapoptotic, and anti-inflammatory properties. However, the third product released in the HO reaction, ferrous iron, may act as pro-oxidative compound when not sufficiently sequestered. In general, HO induction provides protection to stressed cells and thereby helps to restore the physiologic function of tissues. HO also provides cytoprotection to malignant cells, which exploit the upregulation of HO activity to enhance their resistance against oxidative stressors. In order to selectively target cancer, new therapeutics have been developed that kill cells by means of ferroptosis, a form of cell death involving iron. However, for this type of cell death, both a protective and detrimental role of HO in ferroptosis have been described.
It is the aim of this follow-up Special Issue to collect contributions focusing on HO as a therapeutic target for treating sepsis, hypoxia, and ischemia/reperfusion on the one hand, and cancer cells on the other. Experimental studies using appropriate animal models, in vitro studies, and reviews highlighting so far underrated functions of HO are invited. Studies that investigate the role of HO as a signaling molecule are equally well-suited contributions. Additionally, contributions describing new methodological approaches for determining HO activity are also welcome.
Dr. J. Catharina Duvigneau
Guest Editor
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Keywords
- cytoprotection
- ferroptosis
- ferrous iron
- heme degradation
- enzyme activity
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