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Brain Sciences, Volume 8, Issue 12

December 2018 - 26 articles

Cover Story: Targeted treatment development in fragile X syndrome (FXS) has experienced significant interest and associated resources allocation in the last decade. Despite this, no treatments are yet approved for FXS. This issue addresses many lessons learned from past efforts with an eye towards future approaches that will de-risk the FXS translational medicine pipeline. Such efforts will likely span new target identification, improved synchrony of preclinical to clinical evaluation of target engagement, improved treatment effect detection, and overall enhanced broad stakeholder input in the conduct of in particular large-scale trial efforts. The field remains hopeful that meaningful and significant treatment development opportunities remain and with improved development approaches overall success will be enhanced. View Paper here.
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Articles (26)

  • Article
  • Open Access
11 Citations
6,030 Views
20 Pages

19 December 2018

The prefrontal cortex (PFC) is one of the brain regions with more prominent changes in human aging. The molecular processes related to the cognitive decline and mood changes during aging are not completely understood. To improve our knowledge, we int...

  • Review
  • Open Access
13 Citations
4,781 Views
11 Pages

A Homeostatic Model of Subjective Cognitive Decline

  • Akiko Mizuno,
  • Maria Ly and
  • Howard J. Aizenstein

19 December 2018

Subjective Cognitive Decline (SCD) is possibly one of the earliest detectable signs of dementia, but we do not know which mental processes lead to elevated concern. In this narrative review, we will summarize the previous literature on the biomarkers...

  • Review
  • Open Access
21 Citations
6,574 Views
12 Pages

19 December 2018

The Neuron Restrictive Silencer Factor (NRSF) is the well-known master transcriptional repressor of the neuronal phenotype. Research to date has shown that it is an important player in the growth and development of the nervous system. Its role in the...

  • Article
  • Open Access
7 Citations
4,819 Views
12 Pages

Alterations in Motor Cortical Representation of Muscles Following Incomplete Spinal Cord Injury in Humans

  • Hunter J. Fassett,
  • Claudia V. Turco,
  • Jenin El-Sayes and
  • Aimee J. Nelson

16 December 2018

(1) Background: The primary motor cortex (M1) experiences reorganization following spinal cord injury (SCI). However, there is a paucity of research comparing bilateral M1 organization in SCI and questions remain to be answered. We explored the prese...

  • Commentary
  • Open Access
36 Citations
7,269 Views
9 Pages

Best Practices in Fragile X Syndrome Treatment Development

  • Craig A. Erickson,
  • Walter E. Kaufmann,
  • Dejan B. Budimirovic,
  • Ave Lachiewicz,
  • Barbara Haas-Givler,
  • Robert M. Miller,
  • Jayne Dixon Weber,
  • Leonard Abbeduto,
  • David Hessl and
  • Randi J. Hagerman
  • + 1 author

15 December 2018

Preclinical studies using animal models of fragile X syndrome have yielded several agents that rescue a wide variety of phenotypes. However, translation of these treatments to humans with the disorder has not yet been successful, shedding light on a...

  • Editorial
  • Open Access
25 Citations
5,148 Views
3 Pages

13 December 2018

Over the last decade, the emergence of a vast range of new/novel/emerging psychoactive substances (NPS) has progressively changed drug market scenarios, which have shifted from the ‘street’ to a ‘virtual’/online environment. [...

  • Review
  • Open Access
36 Citations
8,082 Views
18 Pages

13 December 2018

Genetics has led to a new focus regarding approaches to the most prevalent diseases today. Ascertaining the molecular secrets of neurodegenerative diseases will lead to developing drugs that will change natural history, thereby affecting the quality...

  • Review
  • Open Access
30 Citations
7,338 Views
19 Pages

13 December 2018

Sleep disturbance after traumatic brain injury (TBI) has received growing interest in recent years, garnering many publications. Insomnia is highly prevalent within the mild traumatic brain injury (mTBI) population and is a subtle, frequently persist...

  • Article
  • Open Access
15 Citations
5,231 Views
15 Pages

11 December 2018

The researcher employed personal belief system (PBS) theory as the theoretical foundation for this study because it holds that teachers’ PBSs may influence their teaching behaviours, teaching styles, and pedagogies in classroom practice due to...

  • Feature Paper
  • Review
  • Open Access
52 Citations
12,047 Views
12 Pages

Nutrition, Energy Expenditure, Dysphagia, and Self-Efficacy in Stroke Rehabilitation: A Review of the Literature

  • Adam C. Lieber,
  • Estee Hong,
  • David Putrino,
  • Dominic A. Nistal,
  • Jonathan S. Pan and
  • Christopher P. Kellner

7 December 2018

While significant research has been performed regarding the use of thrombolytic agents and thrombectomy in the setting of acute stroke, other factors, such as nutritional status of stroke patients, is a less explored topic. The topic of nutrition is...

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Brain Sci. - ISSN 2076-3425Creative Common CC BY license