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Brain Sciences, Volume 11, Issue 6

June 2021 - 153 articles

Cover Story: Multiple sclerosis (MS) is an immune-mediated, inflammatory disease of the central nervous system. The health-related quality of life of persons with MS (PwMS) is often reduced. Fatigue and depression contribute to the impaired health-related quality of life of PwMS. Beyond that, fatigue, depression and health-related quality of life overlap, and their interrelations are complex and have been rarely examined together up to now. In this longitudinal study, we apply path analysis and show that the effect of non-somatic depressive symptomatology on health-related quality of life is fully mediated and, therefore, explainable by an indirect effect via fatigue in PwMS. All three fatigue subscales (physical, psychosocial and cognitive fatigue) mediate this relation between depression and health-related quality of life. View this paper
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Articles (153)

  • Systematic Review
  • Open Access
3 Citations
4,446 Views
10 Pages

Opioid Antagonist in the Treatment of Ischemic Stroke

  • Juan Fernando Ortiz,
  • Claudio Cruz,
  • Amrapali Patel,
  • Mahika Khurana,
  • Ahmed Eissa-Garcés,
  • Ivan Mateo Alzamora,
  • Taras Halan,
  • Abbas Altamimi,
  • Samir Ruxmohan and
  • Urvish K. Patel

Stroke is a leading cause of death and disability, and novel treatments need to be found, particularly drugs with neuroprotective and restorative effects. Lately, there has been an increased interest in the relationship between opioids and ischemic s...

  • Review
  • Open Access
7 Citations
4,396 Views
13 Pages

Mild traumatic brain injury (mTBI) has been defined as a transient (<24 h) condition of confusion and/or loss of consciousness for less than 30 min after brain injury and can result in short- and long-term motor and cognitive impairments. Recent s...

  • Article
  • Open Access
16 Citations
4,464 Views
9 Pages

Microglia Morphological Changes in the Motor Cortex of hSOD1G93A Transgenic ALS Mice

  • Sara Migliarini,
  • Silvia Scaricamazza,
  • Cristiana Valle,
  • Alberto Ferri,
  • Massimo Pasqualetti and
  • Elisabetta Ferraro

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of spinal motor neurons as well as corticospinal (CSN) large pyramidal neurons within cortex layer V. An intense microglia immune response has been associated with b...

  • Article
  • Open Access
6 Citations
3,222 Views
12 Pages

Betel quid (BQ) is one of the most commonly used psychoactive substances in some parts of Asia and the Pacific. Although some studies have shown brain function alterations in BQ chewers, it is virtually impossible for radiologists’ to visually distin...

  • Feature Paper
  • Article
  • Open Access
48 Citations
7,114 Views
16 Pages

Psychological Impact of COVID-19 Outbreak on Families of Children with Autism Spectrum Disorder and Typically Developing Peers: An Online Survey

  • Annalisa Levante,
  • Serena Petrocchi,
  • Federica Bianco,
  • Ilaria Castelli,
  • Costanza Colombi,
  • Roberto Keller,
  • Antonio Narzisi,
  • Gabriele Masi and
  • Flavia Lecciso

Background: When COVID-19 was declared as a pandemic, many countries imposed severe lockdowns that changed families’ routines and negatively impacted on parents’ and children’s mental health. Several studies on families with children with autism spec...

  • Article
  • Open Access
2 Citations
2,738 Views
12 Pages

Translation and Transcultural Adaptation of the Wessex Head Injury Matrix, Italian Version: A Preliminary Report

  • Francesca Pistoia,
  • Agnes Shiel,
  • Raffaele Ornello,
  • Gennaro Saporito,
  • Luca Gentili,
  • Antonio Carolei,
  • Carmine Marini,
  • Simona Sacco and
  • Franco Marinangeli

Background: Patients who are in a coma, a vegetative state or a minimally conscious state present a clinical challenge for neurological assessment, which is a prerequisite for establishing a prognosis and planning management. Several scales have been...

  • Reply
  • Open Access
1 Citations
2,052 Views
2 Pages

It has been an honor for us to receive a comment on our article “Fatal Status Epilepticus in Dravet Syndrome” [...]

  • Article
  • Open Access
7 Citations
4,598 Views
14 Pages

All-Trans Retinoic Acid Fosters the Multifarious U87MG Cell Line as a Model of Glioblastoma

  • Markéta Pokorná,
  • Michael Hudec,
  • Iva Juříčková,
  • Michael Vácha,
  • Zdeňka Polívková,
  • Viera Kútna,
  • Jan Pala,
  • Saak V. Ovsepian,
  • Marie Černá and
  • Valerie Bríd O’Leary

Glioblastoma multiforme (GBM) is a primary brain cancer of poor prognosis, with existing treatments remaining essentially palliative. Current GBM therapy fails due to rapid reappearance of the heterogeneous neoplasm, with models suggesting that the r...

  • Article
  • Open Access
11 Citations
4,746 Views
13 Pages

This study aims to explore specific life experiences and what it means to “live as a sibling of a disabled person”, by focusing on the brothers and sisters of persons with disabilities; this is a cohort that has been relatively marginalized in the fi...

  • Article
  • Open Access
7 Citations
2,481 Views
9 Pages

External Validation and Calibration of the DecaPreT Prediction Model for Decannulation in Patients with Acquired Brain Injury

  • Elio Leto,
  • Danilo Lofaro,
  • Lucia Francesca Lucca,
  • Maria Ursino,
  • Stefania Rogano,
  • Paolo Scola,
  • Paolo Tonin,
  • Domenico Conforti and
  • Antonio Cerasa

We propose a new set of clinical variables for a more accurate early prediction of safe decannulation in patients with severe acquired brain injury (ABI), during a post-acute rehabilitation course. Starting from the already validated DecaPreT scale,...

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Brain Sci. - ISSN 2076-3425