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Microorganisms, Volume 7, Issue 3

March 2019 - 31 articles

Cover Story: Mycobacterial membrane protein large (MmpL) proteins are integral membrane transporters that export large, complex substrates across the plasma membrane of Mycobacterium tuberculosis (Mtb). These substrates play an essential role in Mtb’s physiology and enable its specialized lifestyle as a human pathogen. This review summarizes recent advancements in our understanding of the basis of MmpL-mediated transport and the contribution of MmpL-exported substrates to the virulence and pathogenicity of Mtb in a human host. View this paper.
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Articles (31)

  • Article
  • Open Access
4 Citations
4,780 Views
18 Pages

Urbanization Altered Bacterial and Archaeal Composition in Tidal Freshwater Wetlands Near Washington DC, USA, and Buenos Aires, Argentina

  • Martina Gonzalez Mateu,
  • Cedric Evan Park,
  • Cullen Patrick McAskill,
  • Andrew H. Baldwin and
  • Stephanie A. Yarwood

Urban expansion causes coastal wetland loss, and environmental stressors associated with development can lead to wetland degradation and loss of ecosystem services. This study investigated the effect of urbanization on prokaryotic community compositi...

  • Review
  • Open Access
91 Citations
12,591 Views
16 Pages

Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity. Mycobacterial membrane protein large (MmpL) proteins export bulky, hydropho...

  • Article
  • Open Access
50 Citations
7,093 Views
14 Pages

Bacillus subtilis DSM 32315 Supplementation Attenuates the Effects of Clostridium perfringens Challenge on the Growth Performance and Intestinal Microbiota of Broiler Chickens

  • Cristiano Bortoluzzi,
  • Bruno Serpa Vieira,
  • Juliano Cesar de Paula Dorigam,
  • Anita Menconi,
  • Adebayo Sokale,
  • Kiran Doranalli and
  • Todd Jay Applegate

The objective of this study was to evaluate the effects of the dietary supplementation of Bacillus subtilis DSM 32315 (probiotic) on the performance and intestinal microbiota of broiler chickens infected with Clostridium perfringens (CP). One-day-old...

  • Article
  • Open Access
5 Citations
4,378 Views
25 Pages

Multiple lines of evidence indicate that CD8 + T cells are important in the control of HIV-1 (HIV) replication. However, CD8 + T cells induced by natural infection cannot eliminate the virus or reduce viral loads to acceptably low lev...

  • Review
  • Open Access
74 Citations
12,929 Views
27 Pages

Microbial Population Changes and Their Relationship with Human Health and Disease

  • Ana Isabel Álvarez-Mercado,
  • Miguel Navarro-Oliveros,
  • Cándido Robles-Sánchez,
  • Julio Plaza-Díaz,
  • María José Sáez-Lara,
  • Sergio Muñoz-Quezada,
  • Luis Fontana and
  • Francisco Abadía-Molina

Specific microbial profiles and changes in intestinal microbiota have been widely demonstrated to be associated with the pathogenesis of a number of extra-intestinal (obesity and metabolic syndrome) and intestinal (inflammatory bowel disease) disease...

  • Review
  • Open Access
119 Citations
15,267 Views
26 Pages

Probiotics and Prebiotics for the Amelioration of Type 1 Diabetes: Present and Future Perspectives

  • Sidharth Mishra,
  • Shaohua Wang,
  • Ravinder Nagpal,
  • Brandi Miller,
  • Ria Singh,
  • Subhash Taraphder and
  • Hariom Yadav

Type 1-diabetes (T1D) is an autoimmune disease characterized by immune-mediated destruction of pancreatic beta (β)-cells. Genetic and environmental interactions play an important role in immune system malfunction by priming an aggressive adaptiv...

  • Brief Report
  • Open Access
9 Citations
5,498 Views
11 Pages

In many countries including Japan, the status of emerging antimicrobial resistance among Serratia spp. and Citrobacter spp. in companion animals remains unknown because these genera are rarely isolated from animals. In this study, 30 Serratia spp. an...

  • Review
  • Open Access
53 Citations
7,451 Views
10 Pages

Modulation of the Immune Response to Improve Health and Reduce Foodborne Pathogens in Poultry

  • Christina L. Swaggerty,
  • Todd R. Callaway,
  • Michael H. Kogut,
  • Andrea Piva and
  • Ester Grilli

Salmonella and Campylobacter are the two leading causes of bacterial-induced foodborne illness in the US. Food production animals including cattle, swine, and chickens are transmission sources for both pathogens. The number of Salmonella outbreaks at...

  • Editorial
  • Open Access
8 Citations
3,319 Views
2 Pages

Heat-loving microorganisms or thermophiles arouse noticeable scientific interest nowadays, not only with the aim to elucidate the mystery of life at high temperatures, but also due to the huge field of biotechnological applications of the enzymes the...

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Microorganisms - ISSN 2076-2607