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Probiotics and Colon Cancer

Clinical Microbiology, University of Milan, 20100 Milan, Italy
Microorganisms 2019, 7(3), 66; https://doi.org/10.3390/microorganisms7030066
Received: 4 January 2019 / Revised: 10 February 2019 / Accepted: 23 February 2019 / Published: 28 February 2019
(This article belongs to the Special Issue Gastrointestinal Microbiota Impacts Human Health and Disease)
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Abstract

Literature has recently highlighted the enormous scientific interest on the relationship between the gut microbiota and colon cancer, and how the use of some selected probiotics can have a future impact on the adverse events which occur during this disease. Although there is no clear evidence to claim that probiotics are effective in people with cancer, recent reviews have found that probiotics can significantly reduce the incidence of diarrhea and the average frequency of daily bowel movements. However, most of this evidence needs to be more clinically convincing and further discussed. Undoubtedly, some probiotics, when properly dosed and administered, can have a strong rebalance effect on the gut microbiota and as a consequence a possible positive action on immune modulation of the gastrointestinal tract and on inflammation of the intestinal mucosa. Many recent findings indeed support the hypothesis that the daily use of some selected probiotics can be a feasible approach to effectively protect patients against the risk of some severe consequences due to radiation therapy or chemotherapy. This paper aims to review the most recent articles in order to consider a possible adjuvant approach for the use of certain well-balanced probiotics to help prevent colon cancer and the adverse effects caused by related therapies. View Full-Text
Keywords: colon cancer; gut microbiota; probiotics; anticancer effect colon cancer; gut microbiota; probiotics; anticancer effect
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Drago, L. Probiotics and Colon Cancer. Microorganisms 2019, 7, 66.

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