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Microorganisms 2019, 7(3), 70; https://doi.org/10.3390/microorganisms7030070

MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis

Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR 97239, USA
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Received: 15 January 2019 / Revised: 14 February 2019 / Accepted: 3 March 2019 / Published: 5 March 2019
(This article belongs to the Special Issue Virulence Studies of Pathogenic Mycobacteria of Humans and Animal)
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Abstract

Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity. Mycobacterial membrane protein large (MmpL) proteins export bulky, hydrophobic substrates that are essential for the unique structure of the cell envelope and directly support the ability of Mtb to infect and persist in the host. This review summarizes recent investigations that have enabled insight into the molecular mechanisms underlying MmpL substrate export and the role that these substrates play during Mtb infection. View Full-Text
Keywords: Mycobacterium tuberculosis; lipids; MmpL; lipid transport; cell envelope Mycobacterium tuberculosis; lipids; MmpL; lipid transport; cell envelope
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Melly, G.; Purdy, G.E. MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis. Microorganisms 2019, 7, 70.

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