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Pathogens, Volume 14, Issue 5

May 2025 - 111 articles

Cover Story: This pilot study aimed to assess a novel experimental model of Bartonella henselae, an important zoonotic pathogen. Six ferrets were divided into a control group and two intradermally inoculated infection groups (low and high dose) and then monitored over 7 weeks before being euthanized. Minimal transient clinical signs and laboratory abnormalities developed in inoculated ferrets. The high-dose group seroconverted to B. henselae antigen within two weeks, maintaining elevated titers throughout the study. Histopathological examination revealed inflammatory lesions in the liver parenchyma, heart, and brain of inoculated ferrets; similar lesions were not observed the two control ferrets. Ferrets may serve as a promising model for investigating the pathogenesis, diagnosis, treatment, and prevention of B. henselae. View this paper
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Articles (111)

  • Review
  • Open Access
1 Citations
2,310 Views
17 Pages

Innate immunity is an important component of the immune system and serves as the first line of defense for the host against the invasion of foreign pathogens. Viperin (RSAD2), a core member of the interferon-stimulated gene (ISG) family, plays a key...

  • Review
  • Open Access
2 Citations
2,938 Views
23 Pages

Bacteria and Carcinogenesis and the Management of Cancer: A Narrative Review

  • Paulina Plewa,
  • Kajetan Kiełbowski,
  • Oliwia Mentel,
  • Karolina Figiel,
  • Estera Bakinowska,
  • Rafał Becht,
  • Bolesław Banach and
  • Andrzej Pawlik

There is a widely known relationship between certain microbes and cancer progression. For instance, Helicobacter pylori is associated with the occurrence of gastric cancer, while HPV is associated with cervical and head and neck cancers. Recent studi...

  • Article
  • Open Access
1 Citations
1,811 Views
17 Pages

Human Papillomavirus Positivity and Cognitive Function in Older U.S. Adults: A Cross-Sectional Population-Based Study

  • Thomas J. Farrer,
  • Jonathan D. Moore,
  • Brinley N. Zabriskie,
  • Morgan Chase,
  • Chris H. Miller,
  • Shawn D. Gale and
  • Dawson W. Hedges

Prior research has reported an association between human papillomavirus (HPV) seropositivity and dementia or Alzheimer’s disease. This study aimed to cross-sectionally investigate the association between HPV seropositivity and cognitive functio...

  • Article
  • Open Access
1,225 Views
13 Pages

A Novel flaB Gene-Based Profiling Approach for the Rapid and Accurate Detection of Borreliella and Borrelia Species in Ticks

  • Abigail Dorothea Taylor,
  • Artur Trzebny,
  • Małgorzata Łośko,
  • Jerzy Franciszek Michalik and
  • Miroslawa Dabert

The increasing incidence of tick-borne diseases in Europe necessitates the development of accurate and high-throughput molecular tools for detecting pathogens in tick populations. In this study, we present a novel flaB gene-based profiling method for...

  • Article
  • Open Access
2,939 Views
13 Pages

Prospective Analysis of Clinicopathologic Correlates of At-Home Feline Infectious Peritonitis Treatment Using GS-441524

  • Kelly Larson,
  • Emma Hart,
  • Rosa Negash,
  • Wendy Novicoff,
  • Nicole Jacque and
  • Samantha Evans

Feline Infectious Peritonitis (FIP) is caused by a systemic feline coronavirus (FCoV). Prior to June 2024, compounded FIP treatment was unavailable for prescription by veterinarians in the United States, leading to many cat owners obtaining treatment...

  • Article
  • Open Access
1 Citations
1,578 Views
16 Pages

Temporal Variation and Human Host Predominance in Aedes aegypti from Coastal and Western Kenya: Insights from Pooled Blood Meal Metagenomics

  • Kavinya Mwendwa,
  • Francis Mutuku,
  • Sammy Wambua,
  • Makenzi Nzaro,
  • Bryson A. Ndenga,
  • Kennedy Agoi,
  • Angelle D. LaBeaud and
  • Carren Bosire

Aedes aegypti is the primary vector of arboviral diseases such as dengue, chikungunya, yellow fever, and Zika, posing significant global health and economic challenges. The effective control of this mosquito species requires understanding its seasona...

  • Article
  • Open Access
1,351 Views
13 Pages

A Complete Transfer Learning-Based Pipeline for Discriminating Between Select Pathogenic Yeasts from Microscopy Photographs

  • Ryan A. Parker,
  • Danielle S. Hannagan,
  • Jan H. Strydom,
  • Christopher J. Boon,
  • Jessica Fussell,
  • Chelbie A. Mitchell,
  • Katie L. Moerschel,
  • Aura G. Valter-Franco and
  • Christopher T. Cornelison

Pathogenic yeasts are an increasing concern in healthcare, with species like Candida auris often displaying drug resistance and causing high mortality in immunocompromised patients. The need for rapid and accessible diagnostic methods for accurate ye...

  • Review
  • Open Access
1 Citations
3,439 Views
13 Pages

Objective: This study aimed to review the neurologic and cognitive complications of respiratory syncytial virus (RSV) infections through studies involving infants, children, and adolescents up to 17 years of age. Methods: The PubMed, Scopus, Cochrane...

  • Article
  • Open Access
1 Citations
1,160 Views
17 Pages

The Translationally Controlled Tumor Protein (TCTP), a Novel Antigen of Babesia bovis, Participates in the Establishment of Acute Infection and Contains Neutralizing B-Cell Epitopes

  • Chyntia Pérez-Almeida,
  • Diego Josimar Hernández-Silva,
  • Edwin Esaú Hernández-Arvizu,
  • Masahito Asada,
  • Shin-ichiro Kawazu,
  • Massaro W. Ueti,
  • José Guadalupe Gomez-Soto,
  • Urso Martín Dávila-Montero,
  • Carlos A. Vega y Murguía and
  • Juan Mosqueda

Babesia bovis is a protozoan parasite that causes babesiosis in cattle. It has been hypothesized that in apicomplexan parasites, translationally controlled tumor protein (TCTP) interferes with the host immune response by inhibiting B cell proliferati...

  • Article
  • Open Access
1 Citations
1,161 Views
11 Pages

Escherichia coli contamination in poultry is a significant concern due to its potential to cause foodborne illness. The presence of extraintestinal pathogenic E. coli (ExPEC) strains in chicken carcasses can lead to severe human infections. This stud...

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Pathogens - ISSN 2076-0817