Epidemiology and Molecular Detection of Emerging Fungal Pathogens

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Fungal Pathogens".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 457

Special Issue Editor


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Guest Editor
Department of Infectious/Tropical Diseases and Microbiology, IRCCS Sacro-Cuore Don Calabria, Negrar di Valpolicella, Verona, Italy
Interests: medical mycology; clinical microbiology; antibiotic resistance; epidemiology of hospital infections; diagnosis of sepsis

Special Issue Information

Dear Colleagues,

Fungi are an increasing threat and a growing challenge both for clinical management and public health.

The field of mycology and mycoses aligns closely with the One Health approach proposed by the WHO. This highlights how changes in human activities, environmental factors, and climate have significant epidemiological repercussions. These innovations impact both human, veterinary, and agricultural health, and contribute to the rise in resistance to antifungal drugs, particularly concerning emerging fungal pathogens with limited treatment options. The WHO has included fungi in its list of priority pathogens, but new epidemiological data suggest that this is not exhaustive. There are growing efforts to enhance diagnostics and strengthen resistance surveillance through biomolecular technologies.

In response to these challenges, we propose a Special Issue on “Epidemiology and Molecular Detection of Emerging Fungal Pathogens”. It will address key topics relating to the new etiology, epidemiology, geographic medicine, and clinical aspects of mycoses caused by yeasts, hyaline and dematiaceous fungi, dermatophytes, and lignicolous  and dimorphic mycetes in various clinical settings, including pediatric and elderly patients in LTFCs, travelers, workers, immunocompromised and immunocompetent individuals, and people affected in conflicts or natural disasters. Additionally, we aim at addressing the role of the human mycobiome in fungal infections. Through this Special Issue, we hope to foster a deeper understanding of the risks and challenges posed by fungal pathogens today.

Dr. Claudio Farina
Guest Editor

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Keywords

  • epidemiology
  • molecular detection
  • emerging fungi
  • uncommon presentation

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Published Papers (1 paper)

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Research

13 pages, 1789 KiB  
Article
Genetic Epidemiology and Resistance Investigations of Clinical Yeasts in Alexandria, Egypt
by Bram Spruijtenburg, Carolina Melchior do Prado, Mats van Kempen, Sherine M. Shawky, Jacques F. Meis, Vânia Aparecida Vicente, Flavio Queiroz-Telles, Theun de Groot, Mohammed A. El-Kholy and Eelco F. J. Meijer
Pathogens 2025, 14(5), 486; https://doi.org/10.3390/pathogens14050486 - 15 May 2025
Viewed by 334
Abstract
Yeast bloodstream infections lead to high mortality and morbidity and are mostly observed in immunocompromised patients. In Africa, only a few studies have characterized clinical yeasts. To increase insight into yeast resistance and transmission in Africa, we identified various yeasts from Alexandria, Egypt [...] Read more.
Yeast bloodstream infections lead to high mortality and morbidity and are mostly observed in immunocompromised patients. In Africa, only a few studies have characterized clinical yeasts. To increase insight into yeast resistance and transmission in Africa, we identified various yeasts from Alexandria, Egypt and performed antifungal susceptibility testing (AFST) and genotyping. A total of 1307 single isolates from unique patients, recovered from different anatomical sites including the bloodstream, retrieved from a reference laboratory in Alexandria, Egypt were studied. All isolates were identified with MALDI-TOF MS, while some were initially identified with a Vitek 2 Compact system. Short tandem repeat (STR) genotyping was performed for the most common species, and AFST was performed with microbroth dilution. Among bloodstream isolates (n = 71), C. albicans was the most common etiological agent, followed by C. tropicalis and C. parapsilosis. Comparison of yeast identification methods demonstrated that 22% of isolates were incorrectly identified with the Vitek 2 Compact system compared to MALDI-TOF MS. Multiple rare yeasts showed reduced antifungal susceptibility. STR genotyping demonstrated potential events of nosocomial transmission with N. glabratus and C. parapsilosis. Moreover, an azole-resistant C. tropicalis clade identified earlier in Alexandria was still present. To conclude, clinical yeasts in Alexandria, Egypt, are overall susceptible common species. Full article
(This article belongs to the Special Issue Epidemiology and Molecular Detection of Emerging Fungal Pathogens)
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