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Pathogens, Volume 12, Issue 7

July 2023 - 117 articles

Cover Story: A major roadblock to achieving a cure for HIV-1 is the persistence of latent viral infections. Given the host-specificity, there are few animal models that replicate the natural course of HIV infection with precision, underlining the importance of humanized mouse models for viral latency and its elimination studies. The hu-PBL model is tested for quick screening of antiretroviral therapies lasting 4–5 weeks. The hu-BLT model involves the transplantation of human HSCs, fetal liver, and thymus tissue into immunocompromised mice and has been tested for HIV infection and latency studies lasting up to three months. The hu-HSC model utilizes transplantation of hematopoietic stem cells to generate a functional human immune system, lasting up to one year, allowing long-term HIV infection and therapeutic studies, including the first report of an HIV cure. View this paper
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Articles (117)

  • Case Report
  • Open Access
8 Citations
2,360 Views
9 Pages

Novel Metallo-β-Lactamase blaCVI-1 Isolated from a Chromobaterium violaceum Clinical Strain Resistant to Colistin

  • Sonia A. Gomez,
  • María Belén Sanz,
  • Melina Rapoport,
  • Graciela Sucin,
  • Teresa A. Corallo,
  • Tomás Poklepovich,
  • Josefina Campos,
  • Paola Ceriana,
  • Juan Manuel de Mendieta and
  • Mónica Prieto
  • + 2 authors

Objective: We aimed to describe a colistin (COL)-resistant (R) Chromobacterium violaceum (Cvi) isolate from a septic patient in Argentina expressing a previously unknown gene, blaCVI-1. Methods: In 2019, a 12 year old child was injured with a thorn i...

  • Article
  • Open Access
4 Citations
2,538 Views
22 Pages

Campylobacter spp. are known to cause campylobacteriosis, a bacterial disease that remains a public health threat. Campylobacter spp. are prevalent in retail meat and liver products, and the prolonged survival of Campylobacter in the low temperatures...

  • Article
  • Open Access
12 Citations
2,475 Views
20 Pages

A Prior Usutu Virus Infection Can Protect Geese from Severe West Nile Disease

  • Hannah Reemtsma,
  • Cora M. Holicki,
  • Christine Fast,
  • Felicitas Bergmann,
  • Martin H. Groschup and
  • Ute Ziegler

Usutu virus (USUV) and West Nile virus (WNV) are closely related pathogens circulating between mosquitoes and birds, but also infecting mammals as dead-end hosts. Both viruses share the same susceptible hosts, vectors, and even distribution areas in...

  • Article
  • Open Access
6 Citations
2,962 Views
13 Pages

Estimating the Prevalence of Foodborne Pathogen Campylobacter jejuni in Chicken and Its Control via Sorghum Extracts

  • Gamal M. Hamad,
  • Mariam Gerges,
  • Taha Mehany,
  • Saleh M. Hussein,
  • Michael Eskander,
  • Rasha G. Tawfik,
  • Yasser El-Halmouch,
  • Alaa M. Mansour,
  • Elsayed E. Hafez and
  • Tuba Esatbeyoglu
  • + 1 author

Campylobacter jejuni is a Gram-negative bacterium which is considered as the most reported cause of foodborne infection, especially for poultry species. The object of this work is to evaluate the occurrence of C. jejuni in chicken meat as well its co...

  • Systematic Review
  • Open Access
30 Citations
5,836 Views
17 Pages

Entomopathogens and Parasitoids Allied in Biocontrol: A Systematic Review

  • Janique Koller,
  • Louis Sutter,
  • Jérémy Gonthier,
  • Jana Collatz and
  • Lindsey Norgrove

Biological pest control is an environmentally friendly alternative to synthetic pesticides, using organisms such as viruses, bacteria, fungi, and parasitoids. However, efficacy is variable and combining different biocontrol agents could improve succe...

  • Brief Report
  • Open Access
1,940 Views
12 Pages

G6P[8] Rotavirus a Possessing a Wa-like VP3 Gene from a Child with Acute Gastroenteritis Living in the Northwest Amazon Region

  • Marcia Terezinha Baroni de Moraes,
  • Mauro França da Silva,
  • Yan Cardoso Pimenta,
  • Carina Pacheco Cantelli,
  • Rosane Maria Santos de Assis,
  • Alexandre Madi Fialho,
  • Marina Galvão Bueno,
  • Alberto Ignácio Olivares Olivares,
  • Lennart Svensson and
  • José Paulo Gagliardi Leite
  • + 1 author

The introduction of rotavirus A (RVA) vaccines has considerably reduced the RVA-associated mortality among children under 5 years of age worldwide. The ability of RVA to reassort gives rise to different combinations of surface proteins G (glycoprotei...

  • Article
  • Open Access
3 Citations
3,102 Views
14 Pages

Community Health-Education Intervention Trial against Human Taenia solium Taeniasis/Cysticercosis in Central and Southern Zones of Tanzania

  • George Makingi,
  • Bernard Ngowi,
  • Ernatus Mkupasi,
  • Christina Wilson,
  • Andrea Sylvia Winkler,
  • Jahashi Nzalawahe and
  • Helena Ngowi

Poor knowledge of human T. solium taeniasis/cysticercosis and insufficient sanitary and hygienic practices have been associated with the persistence of human T. solium infections in endemic areas. Community health education intervention measures were...

  • Article
  • Open Access
9 Citations
2,688 Views
11 Pages

Impact of the Food-Related Stress Conditions on the Expression of Enterotoxin Genes among Staphylococcus aureus

  • Joanna Gajewska,
  • Arkadiusz Józef Zakrzewski,
  • Wioleta Chajęcka-Wierzchowska and
  • Anna Zadernowska

Staphylococcus aureus is one of the most important foodborne pathogens. S. aureus has the capability to produce a variety of toxins, including staphylococcal enterotoxins (SEs). The aim of this study was to evaluate the survival rate of S. aureus cel...

  • Review
  • Open Access
9 Citations
6,953 Views
25 Pages

Mouse Models for Human Herpesviruses

  • Ivana Kutle,
  • Anne Dittrich and
  • Dagmar Wirth

More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health. To investig...

  • Article
  • Open Access
9 Citations
7,270 Views
22 Pages

Art of the Kill: Designing and Testing Viral Inactivation Procedures for Highly Pathogenic Negative Sense RNA Viruses

  • Judith Olejnik,
  • Adam J. Hume,
  • Stephen J. Ross,
  • Whitney A. Scoon,
  • Scott Seitz,
  • Mitchell R. White,
  • Ben Slutzky,
  • Nadezhda E. Yun and
  • Elke Mühlberger

The study of highly pathogenic viruses handled under BSL-4 conditions and classified as Select Agents frequently involves the transfer of inactivated materials to lower containment levels for downstream analyses. Adhering to Select Agent and BSL-4 sa...

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Pathogens - ISSN 2076-0817