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Pathogens, Volume 12, Issue 6

2023 June - 107 articles

Cover Story: Neuromeningeal cryptococcosis is a life-threatening infection of the central nervous system, caused by encapsulated yeast belonging to the Cryptococcus neoformans and Cryptococcus gattii species complexes. There is an increase in resistance to fluconazole for yeasts of the C. gattii species complex, and the virulence is variable according to the genotype. We demonstrated that fluconazole-induced resistant strains are less virulent when compared to the original susceptible strains. In contrast, the clinically resistant strain maintains its virulence compared to fluconazole-susceptible strains of the same sequence type. View this paper
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Articles (107)

  • Review
  • Open Access
47 Citations
6,268 Views
14 Pages

The extensive use of antibiotics in animal production has led to the development of antibiotic-resistant microorganisms and the search for alternative antimicrobial agents in animal production. One such compound may be antimicrobial peptides (AMPs),...

(This article belongs to the Special Issue Elimination of Pathogenic Microorganisms by Natural and Synthetic Compounds)
  • Article
  • Open Access
14 Citations
5,799 Views
17 Pages

Plectranthus amboinicus (Indian borage) has been extensively studied for its medicinal properties, which can be exploited to develop new antimicrobial therapeutics. The current study investigated the effect of Plectranthus amboinicus leaf extracts on...

(This article belongs to the Special Issue Advances in Treatment of Biofilm Infections)
  • Article
  • Open Access
9 Citations
6,083 Views
19 Pages

TRIM16 Overexpression in HEK293T Cells Results in Cell Line-Specific Antiviral Activity

  • Lance R. Nigos,
  • Nichollas E. Scott,
  • Andrew G. Brooks,
  • Malika Ait-Goughoulte and ,
  • Sarah L. Londrigan,
  • Patrick. C. Reading and
  • Rubaiyea Farrukee
  • + 2 authors+ 0 author

Host cell restriction factors are intracellular proteins that can inhibit virus replication. Characterisation of novel host cell restriction factors can provide potential targets for host-directed therapies. In this study, we aimed to assess a member...

(This article belongs to the Section Viral Pathogens)
  • Review
  • Open Access
21 Citations
12,897 Views
21 Pages

Human angiostrongylosis is an emerging zoonosis caused by the larvae of three species of metastrongyloid nematodes of the genus Angiostrongylus, with Angiostrongylus cantonensis (Chen, 1935) being dominant across the world. Its obligatory heteroxenou...

(This article belongs to the Special Issue Rat Lungworm Disease)
  • Article
  • Open Access
5 Citations
3,506 Views
21 Pages

Risk Factors for Hepatitis E Virus Infection and Eating Habits in Kidney Transplant Recipients

  • Eva Wu,
  • Nadine Koch,
  • Friederike Bachmann,
  • Marten Schulz and ,
  • Evelyn Seelow,
  • Ulrike Weber,
  • Johannes Waiser,
  • Fabian Halleck,
  • Mirko Faber and
  • Mira Choi
  • + 10 authors+ 5 authors

There is a significant risk for ongoing and treatment-resistant courses of hepatitis E virus (HEV) infection in patients after solid organ transplantation. The aim of this study was to identify risk factors for the development of hepatitis E, includi...

(This article belongs to the Special Issue Hepatitis E Virus (HEV) Infection among Humans and Animals: Epidemiology, Clinical Characteristics, Treatment and Prevention)
  • Article
  • Open Access
7 Citations
2,751 Views
13 Pages

Estimating the Impact of Consecutive Blood Meals on Vector Competence of Aedes albopictus for Chikungunya Virus

  • Eva Veronesi,
  • Anca Paslaru,
  • Julia Ettlin,
  • Damiana Ravasi and ,
  • Eleonora Flacio,
  • Matteo Tanadini and
  • Valeria Guidi
  • + 2 authors+ 0 author

The continuous expansion of Aedes albopictus in Europe and the increases in autochthonous arboviruses transmissions in the region urge a better understanding of the virus transmission dynamic. Recent work described enhanced chikungunya virus (CHIKV)...

(This article belongs to the Section Viral Pathogens)
  • Article
  • Open Access
13 Citations
4,244 Views
12 Pages

Dose-Dependent Inhibitory Effect of Probiotic Lactobacillus plantarum on Streptococcus mutans-Candida albicans Cross-Kingdom Microorganisms

  • Jianhang Bao,
  • Xinyan Huang,
  • Yan Zeng,
  • Tong Tong Wu and ,
  • Xingyi Lu,
  • Gina Meng,
  • Yanfang Ren and
  • Jin Xiao
  • + 3 authors+ 0 author

Dental caries is one of the most common chronic diseases worldwide. Streptococcus mutans and Candida albicans are two major pathogens associated with dental caries. Several recent studies revealed that Lactobacillus plantarum inhibits S. mutans and C...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
2,118 Views
16 Pages

Barriers with Valve Mechanisms Are Predicted to Protect Crops from Slug Carriers of Rat Lungworm Disease

  • Genevieve C. Pang,
  • Amy T. Hou,
  • Ryan Tamashiro,
  • Kristin M. Mills and
  • Lorrin W. Pang

Angiostrongyliasis (Rat Lungworm disease) is an emerging parasitic disease caused by the ingestion of gastropods infected with the neurotropic nematode Angiostrongylus cantonensis. The reduction of crop infestation with infected slug carriers may var...

(This article belongs to the Special Issue Rat Lungworm Disease)
  • Article
  • Open Access
9 Citations
3,612 Views
25 Pages

The Immune Response in the Uteri and Placentae of Chlamydia abortus-Infected Ewes and Its Association with Pregnancy Outcomes

  • Sergio Gaston Caspe,
  • David Andrew Ewing,
  • Morag Livingstone,
  • Clare Underwood and ,
  • Elspeth Milne,
  • Neil Donald Sargison,
  • Sean Ranjan Wattegedera and
  • David Longbottom
  • + 3 authors+ 0 author

The enzootic abortion of ewes, caused by the bacterium Chlamydia abortus (C. abortus), is one of the main causes of abortion in sheep. There are multiple contributory factors, including chlamydial growth, host immune response, and hormonal balance, t...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
15 Citations
3,285 Views
15 Pages

Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus by Disrupting Virus Entry

  • Caisheng Zhang,
  • Huan Chen,
  • Liumei Sun,
  • Pu Zhao and ,
  • Chuanxiang Qi,
  • Ying Yang,
  • Anqi Si,
  • Yingjuan Qian and
  • Yong-Sam Jung
  • + 4 authors+ 0 author

The porcine epidemic diarrhea virus (PEDV), belonging to the α-coronavirus, is the causative agent of porcine epidemic diarrhea (PED). Presently, protection from the existing PEDV vaccine is not effective. Therefore, anti-PEDV compounds should...

(This article belongs to the Special Issue Swine Viral Diseases)
  • Article
  • Open Access
12 Citations
4,198 Views
20 Pages

Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine in Pregnancy: Low Coverage and High Prevalence of Plasmodium falciparum dhfr-dhps Quintuple Mutants as Major Challenges in Douala, an Urban Setting in Cameroon

  • Carole Else Eboumbou Moukoko,
  • Loick Pradel Kojom Foko,
  • Angèle Ayina,
  • Bernard Tornyigah and ,
  • Annie Rachel Epote,
  • Ida Calixte Penda,
  • Patricia Epee Eboumbou,
  • Serge Bruno Ebong,
  • Gaetan Texier and
  • Albert Same Ekobo
  • + 8 authors+ 3 authors

Intermittent preventive treatment in pregnancy with sulfadoxine and pyrimethamine (IPTp-SP) is a key component in the malaria control strategy implemented in Africa. The aim of this study was to determine IPTp-SP adherence and coverage, and the impac...

(This article belongs to the Section Parasitic Pathogens)
  • Brief Report
  • Open Access
3 Citations
3,355 Views
13 Pages

Oral Epithelial Cells Expressing Low or Undetectable Levels of Human Angiotensin-Converting Enzyme 2 Are Susceptible to SARS-CoV-2 Virus Infection In Vitro

  • Laith Ebraham,
  • Chuan Xu,
  • Annie Wang,
  • Cyril Hernandez and ,
  • Nicholas Siclari,
  • Divino Rajah,
  • Lewins Walter,
  • Salvatore A. E. Marras,
  • Sanjay Tyagi and
  • Theresa L. Chang
  • + 7 authors+ 2 authors

The oral cavity is thought to be one of the portals for SARS-CoV-2 entry, although there is limited evidence of active oral infection by SARS-CoV-2 viruses. We assessed the capacity of SARS-CoV-2 to infect and replicate in oral epithelial cells. Oral...

(This article belongs to the Collection SARS-CoV Infections)
  • Article
  • Open Access
7 Citations
3,197 Views
12 Pages

Discovery of Terpenes as Novel HCV NS5B Polymerase Inhibitors via Molecular Docking

  • Tomasz M. Karpiński,
  • Marcin Ożarowski,
  • Pedro J. Silva,
  • Mark Stasiewicz and ,
  • Rahat Alam and
  • Abdus Samad
  • + 1 author+ 0 author

Hepatitis C virus (HCV) is a dangerous virus that is responsible for a large number of infections and deaths worldwide. In the treatment of HCV, it is important that the drugs are effective and do not have additional hepatotoxic effects. The aim of t...

(This article belongs to the Special Issue Advances in HCV Research)
  • Article
  • Open Access
10 Citations
5,556 Views
11 Pages

This retrospective study aimed to evaluate the clinical use and side effects of fosfomycin in critically ill patients in Taiwan. Forty-two patients (mean age, 69.9 years; female, 69%) who received fosfomycin were included from a teaching hospital in...

(This article belongs to the Section Bacterial Pathogens)
  • Review
  • Open Access
7 Citations
7,723 Views
19 Pages

What about the Cytoskeletal and Related Proteins of Tapeworms in the Host’s Immune Response? An Integrative Overview

  • Diana G. Ríos-Valencia,
  • Javier Ambrosio,
  • Rocío Tirado-Mendoza,
  • Julio César Carrero and
  • Juan Pedro Laclette

Recent advances have increased our understanding of the molecular machinery in the cytoskeleton of mammalian cells, in contrast to the case of tapeworm parasites, where cytoskeleton remains poorly characterized. The pertinence of a better knowledge o...

(This article belongs to the Section Immunological Responses and Immune Defense Mechanisms)
  • Review
  • Open Access
54 Citations
23,716 Views
23 Pages

Virulence Factors of Mycobacterium tuberculosis as Modulators of Cell Death Mechanisms

  • Lucero A. Ramon-Luing,
  • Yadira Palacios,
  • Andy Ruiz,
  • Norma A. Téllez-Navarrete and
  • Leslie Chavez-Galan

Mycobacterium tuberculosis (Mtb) modulates diverse cell death pathways to escape the host immune responses and favor its dissemination, a complex process of interest in pathogenesis-related studies. The main virulence factors of Mtb that alter cell d...

(This article belongs to the Section Immunological Responses and Immune Defense Mechanisms)
  • Review
  • Open Access
20 Citations
5,676 Views
23 Pages

Metallic Nanoparticles and Core-Shell Nanosystems in the Treatment, Diagnosis, and Prevention of Parasitic Diseases

  • Grzegorz Król,
  • Kamila Fortunka,
  • Michał Majchrzak,
  • Ewelina Piktel and ,
  • Paulina Paprocka,
  • Angelika Mańkowska,
  • Agata Lesiak,
  • Maciej Karasiński,
  • Agnieszka Strzelecka and
  • Robert Bucki
  • + 6 authors+ 1 author

The usage of nanotechnology in the fight against parasitic diseases is in the early stages of development, but it brings hopes that this new field will provide a solution to target the early stages of parasitosis, compensate for the lack of vaccines...

(This article belongs to the Section Parasitic Pathogens)
  • Article
  • Open Access
14 Citations
2,894 Views
11 Pages

Prevalence, Serotypes, Antimicrobial Resistance and Biofilm-Forming Ability of Listeria monocytogenes Isolated from Bulk-Tank Bovine Milk in Northern Greece

  • Apostolos S. Angelidis,
  • Afroditi S. Grammenou,
  • Charalampos Kotzamanidis,
  • Nektarios D. Giadinis and ,
  • Antonios G. Zdragas and
  • Daniel Sergelidis
  • + 1 author+ 0 author

The prevalence of Listeria monocytogenes in bovine bulk-tank milk (BTM) in Greece has not been previously investigated. The aim of the study was to estimate the prevalence of L. monocytogenes in bovine BTM in Greece and to characterize the isolates i...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
28 Citations
4,764 Views
15 Pages

Prevalence of Enterococcus spp. and the Whole-Genome Characteristics of Enterococcus faecium and Enterococcus faecalis Strains Isolated from Free-Living Birds in Poland

  • Renata Kwit,
  • Magdalena Zając,
  • Aleksandra Śmiałowska-Węglińska,
  • Magdalena Skarżyńska and ,
  • Arkadiusz Bomba,
  • Anna Lalak,
  • Ewelina Skrzypiec,
  • Dominika Wojdat,
  • Weronika Koza and
  • Dariusz Wasyl
  • + 10 authors+ 5 authors

Enterococci as opportunistic bacteria are important for human health. Due to the prevalence and ease of acquisition and transfer of their genes, they are an excellent indicator of environmental contamination and the spread of antimicrobial resistance...

(This article belongs to the Special Issue Surveillance of Zoonotic Pathogens Carried by Wildlife)
  • Article
  • Open Access
4 Citations
2,565 Views
11 Pages

Neutralizing Antibodies against the SARS-CoV-2 Ancestral Strain and Omicron BA.1 Subvariant in Dogs and Cats in Mexico

  • Freddy Dehesa-Canseco,
  • Roxana Pastrana-Unzueta,
  • Nadia Carrillo-Guzmán,
  • Francisco Liljehult-Fuentes and ,
  • Juan Diego Pérez-De la Rosa,
  • Humberto Ramírez-Mendoza,
  • Jose Guillermo Estrada-Franco,
  • Roberto Navarro-López,
  • Jesús Hernández and
  • Mario Solís-Hernández
  • + 5 authors+ 0 author

SARS-CoV-2 mainly affects humans; however, it is important to monitor the infection of companion and wild animals as possible reservoirs of this virus. In this sense, seroprevalence studies in companion animals, such as dogs and cats, provide importa...

(This article belongs to the Topic Immune Response to Zoonotic Pathogens)
  • Article
  • Open Access
7 Citations
3,874 Views
12 Pages

Growth of V. parahaemolyticus in Tropical Blacklip Rock Oysters

  • Anna C. Padovan,
  • Alison R. Turnbull,
  • Samantha J. Nowland,
  • Matthew W. J. Osborne and ,
  • Mirjam Kaestli,
  • Justin R. Seymour and
  • Karen S. Gibb
  • + 2 authors+ 0 author

The opportunistic pathogen Vibrio parahaemolyticus poses a significant food safety risk worldwide, and understanding its growth in commercially cultivated oysters, especially at temperatures likely to be encountered post-harvest, provides essential i...

  • Communication
  • Open Access
15 Citations
4,171 Views
9 Pages

The canine distemper virus (CDV), a paramyxovirus that is closely related to the human measles virus and rinderpest virus of cattle, is a highly contagious viral disease in dogs and wild carnivores worldwide. CDV represents a serious threat to domest...

(This article belongs to the Collection Feature Papers in Viral Pathogens)
  • Article
  • Open Access
10 Citations
3,820 Views
17 Pages

The Eradication of Helicobacter pylori Was Significantly Associated with Compositional Patterns of Orointestinal Axis Microbiota

  • Sally Ali Tawfik,
  • Marwa Azab,
  • Mohammed Ramadan,
  • Sarah Shabayek and ,
  • Ali Abdellah,
  • Sultan S. Al Thagfan and
  • Mohammed Salah
  • + 2 authors+ 0 author

Background: Helicobacter pylori (H. pylori) is significantly linked to various diseases that seriously impact human health, such as gastric ulcers, chronic gastritis and gastric adenocarcinoma. Methods: The compositional shifts in bacterial communiti...

  • Article
  • Open Access
2 Citations
3,387 Views
21 Pages

Upregulation of Neuropilin-1 Inhibits HTLV-1 Infection

  • Wesley Kendle,
  • Kimson Hoang,
  • Erica Korleski,
  • Amanda R. Panfil and ,
  • Nicholas Polakowski and
  • Isabelle Lemasson
  • + 1 author+ 0 author

Infection with human T-cell leukemia virus type 1 (HTLV-1) can produce a spectrum of pathological effects ranging from inflammatory disorders to leukemia. In vivo, HTLV-1 predominantly infects CD4+ T-cells. Infectious spread within this population in...

(This article belongs to the Special Issue New Directions in HTLV-1 Research)
  • Article
  • Open Access
17 Citations
6,699 Views
11 Pages

The Sarcoptic Mange in Maned Wolf (Chrysocyon brachyurus): Mapping an Emerging Disease in the Largest South American Canid

  • Flávia Fiori,
  • Rogério Cunha de Paula,
  • Pedro Enrique Navas-Suárez,
  • Ricardo Luiz Pires Boulhosa and
  • Ricardo Augusto Dias

The maned wolf (Chrysocyon brachyurus) is the largest South American canid. In Brazil, as in other countries, it is considered an endangered species. Habitat loss, landscape changes, hunting, and roadkill are the main threats to this species. In addi...

(This article belongs to the Special Issue Emerging Infections in Domestic Animals)
  • Article
  • Open Access
12 Citations
3,999 Views
11 Pages

Small Ruminant Lentivirus Infection in Sheep and Goats in North Portugal: Seroprevalence and Risk Factors

  • João Jacob-Ferreira,
  • Ana Cláudia Coelho,
  • Ana Grau Vila,
  • Delia Lacasta and
  • Hélder Quintas

Small ruminant lentiviruses (SRLVs) are transmitted among ovine and caprine species. This disease is a severe problem for small ruminant production, not only for animals’ well-being but also for flocks’ efficiency. The main aim of this re...

(This article belongs to the Special Issue Women’s Special Issue Series: Pathogens)
  • Article
  • Open Access
13 Citations
3,196 Views
12 Pages

Increased antimicrobial resistance highlights the need for alternatives to antibiotics. Bacteriophages, which are benign viruses that kill bacteria, are promising. We studied the efficacy of topical bacteriophages for treating equine staphylococcal s...

  • Article
  • Open Access
3 Citations
2,629 Views
11 Pages

Low Prevalence of Toxoplasma gondii in Sheep and Isolation of a Viable Strain from Edible Mutton from Central China

  • Yibao Jiang,
  • Shilin Xin,
  • Yiheng Ma,
  • Heng Zhang and ,
  • Xu Yang and
  • Yurong Yang
  • + 1 author+ 0 author

Sheep are highly susceptible to Toxoplasma gondii, and miscarriage is the main clinical feature. This study investigated 227 sheep samples (210 myocardial tissues from slaughterhouses, 6 ewe serum samples, 3 aborted fetuses, and 8 dead lambs from vet...

(This article belongs to the Special Issue Toxoplasma Infection: Current Problems, Progress and New Challenges)
  • Article
  • Open Access
4 Citations
2,957 Views
10 Pages

Rodents as Sentinels for Toxoplasma gondii in Rural Ecosystems in Slovakia—Seroprevalence Study

  • Daniela Antolová,
  • Michal Stanko,
  • Júlia Jarošová and
  • Dana Miklisová

Toxoplasma gondii is a ubiquitous intracellular parasite with felids as definitive hosts and a broad range of intermediate hosts. Rodents are considered suitable sentinels for prevalence studies of many infections, including toxoplasmosis. This study...

(This article belongs to the Section Parasitic Pathogens)
  • Review
  • Open Access
15 Citations
6,843 Views
19 Pages

Xylem Embolism and Pathogens: Can the Vessel Anatomy of Woody Plants Contribute to X. fastidiosa Resistance?

  • Giambattista Carluccio,
  • Davide Greco,
  • Erika Sabella,
  • Marzia Vergine and ,
  • Luigi De Bellis and
  • Andrea Luvisi
  • + 1 author+ 0 author

The maintenance of an intact water column in the xylem lumen several meters above the ground is essential for woody plant viability. In fact, abiotic and biotic factors can lead to the formation of emboli in the xylem, interrupting sap flow and causi...

(This article belongs to the Special Issue Pathogens in 2023)
  • Article
  • Open Access
27 Citations
15,170 Views
25 Pages

Survey, Detection, Characterization of Papaya Ringspot Virus from Southern India and Management of Papaya Ringspot Disease

  • Udavatha Premchand,
  • Raghavendra K. Mesta,
  • Venkatappa Devappa,
  • Mantapla Puttappa Basavarajappa and ,
  • Venkataravanappa Venkataravanappa,
  • Lakshminarayana Reddy C. Narasimha Reddy and
  • Kodegandlu Subbanna Shankarappa
  • + 2 authors+ 0 author

Papaya ringspot virus (PRSV) is a significant threat to global papaya cultivation, causing ringspot disease, and it belongs to the species Papaya ringspot virus, genus Potyvirus, and family Potyviridae. This study aimed to assess the occurrence and s...

(This article belongs to the Section Viral Pathogens)
  • Editorial
  • Open Access
2 Citations
2,252 Views
4 Pages

Among the seven coronaviruses that infect humans, HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 usually cause mild and common cold symptoms; however, infection with three coronaviruses, namely severe acute respiratory syndrome coronavirus [SARS-CoV]...

(This article belongs to the Section Viral Pathogens)
  • Case Report
  • Open Access
16 Citations
8,889 Views
11 Pages

Feline Parvovirus Lethal Outbreak in a Group of Adult Cohabiting Domestic Cats

  • Maria Irene Pacini,
  • Mario Forzan,
  • Giovanni Franzo,
  • Claudia Maria Tucciarone and ,
  • Milena Fornai,
  • Fabrizio Bertelloni,
  • Micaela Sgorbini,
  • Carlo Cantile and
  • Maurizio Mazzei
  • + 4 authors+ 0 author

Feline panleukopenia is a highly contagious and often fatal disease in cats. The virus, known as feline panleukopenia virus (FPV), primarily affects kittens and unvaccinated cats. It is transmitted through contact with infected cats or their bodily f...

(This article belongs to the Special Issue Diagnostics of Animal Viral Infectious Diseases)
  • Article
  • Open Access
6 Citations
3,051 Views
22 Pages

Effect of Local Administration of Meglumine Antimoniate and Polyhexamethylene Biguanide Alone or in Combination with a Toll-like Receptor 4 Agonist for the Treatment of Papular Dermatitis due to Leishmania infantum in Dogs

  • Icíar Martínez-Flórez,
  • Maria Jose Guerrero,
  • Annabel Dalmau,
  • Maria Cabré and ,
  • Maria Magdalena Alcover,
  • Diana Berenguer,
  • Liam Good,
  • Roser Fisa,
  • Cristina Riera and
  • Laia Solano-Gallego
  • + 6 authors+ 1 author

Papular dermatitis is a cutaneous manifestation of canine Leishmania infantum infection associated with mild disease. Although it is a typical presentation, nowadays, there is still no established treatment. This study evaluated the safety and clinic...

(This article belongs to the Section Vaccines and Therapeutic Developments)
  • Article
  • Open Access
18 Citations
5,423 Views
27 Pages

Genetic Mapping, Candidate Gene Identification and Marker Validation for Host Plant Resistance to the Race 4 of Fusarium oxysporum f. sp. cubense Using Musa acuminata ssp. malaccensis

  • Andrew Chen,
  • Jiaman Sun,
  • Altus Viljoen,
  • Diane Mostert and ,
  • Yucong Xie,
  • Leroy Mangila,
  • Sheryl Bothma,
  • Rebecca Lyons,
  • Eva Hřibová and
  • Elizabeth A. B. Aitken
  • + 20 authors+ 15 authors

Fusarium wilt of banana is a devastating disease that has decimated banana production worldwide. Host resistance to Fusarium oxysporum f. sp. Cubense (Foc), the causal agent of this disease, is genetically dissected in this study using two Musa acumi...

(This article belongs to the Special Issue Current Research on Fusarium)
  • Article
  • Open Access
12 Citations
11,559 Views
22 Pages

Curcumin and Its Supramolecular Complex with Disodium Glycyrrhizinate as Potential Drugs for the Liver Fluke Infection Caused by Opisthorchis felineus

  • Maria N. Lvova,
  • Denis V. Ponomarev,
  • Alena A. Tarasenko,
  • Anna V. Kovner and ,
  • Galina A. Minkova,
  • Michail A. Tsyganov,
  • Meijun Li,
  • Yan Lou,
  • Veronica I. Evseenko and
  • Damira F. Avgustinovich
  • + 9 authors+ 4 authors

Opisthorchiosis is a parasitic liver disease found in mammals that is widespread throughout the world and causes systemic inflammation. Praziquantel remains the drug of choice for the treatment of opisthorchiosis, despite its many adverse effects. An...

(This article belongs to the Special Issue Veterinary Parasitic Diseases: Advancements in Diagnostics, Therapeutics, and Vaccines)
  • Article
  • Open Access
9 Citations
2,795 Views
17 Pages

Latent Tuberculosis Patients Have an Increased Frequency of IFN-γ-Producing CD5+ B Cells, Which Respond Efficiently to Mycobacterial Proteins

  • Julio Flores-Gonzalez,
  • Lucero A. Ramón-Luing,
  • Jesus Romero-Tendilla,
  • Alexia Urbán-Solano and ,
  • Alfredo Cruz-Lagunas and
  • Leslie Chavez-Galan
  • + 1 author+ 0 author

Tuberculosis (TB) remains a public health problem worldwide and is one of the deadliest infectious diseases, only after the current COVID-19 pandemic. Despite significant advances in the TB field, there needs to be more immune response comprehension;...

(This article belongs to the Section Immunological Responses and Immune Defense Mechanisms)
  • Review
  • Open Access
33 Citations
7,004 Views
12 Pages

The immune system is a complex network of multiple cells, tissues, and organs that protects the body against foreign pathogenic invaders. However, the immune system may mistakenly attack healthy cells and tissues due to the cross-reactivity of anti-p...

(This article belongs to the Section Immunological Responses and Immune Defense Mechanisms)
  • Review
  • Open Access
6 Citations
6,055 Views
18 Pages

Nondestructive Methods of Pathogen Detection: Importance of Mosquito Integrity in Studies of Disease Transmission and Control

  • Anne Caroline Alves Meireles,
  • Flávia Geovana Fontineles Rios,
  • Luiz Henrique Maciel Feitoza,
  • Lucas Rosendo da Silva and
  • Genimar Rebouças Julião

Mosquitoes are vectors of many pathogens, including viruses, protozoans, and helminths, spreading these pathogens to humans as well as to wild and domestic animals. As the identification of species and the biological characterization of mosquito vect...

  • Feature Paper
  • Review
  • Open Access
10 Citations
8,528 Views
15 Pages

Chronic viral hepatitis infections, caused by the hepatitis B or C virus, are a major global health problem causing an estimated one million deaths each year. Immunological studies have classically focused on T cells, while B cells have largely been...

(This article belongs to the Section Viral Pathogens)
  • Article
  • Open Access
15 Citations
4,605 Views
18 Pages

CLEAR Strategy Inhibited HSV Proliferation Using Viral Vectors Delivered CRISPR-Cas9

  • Min Ying,
  • Huadong Wang,
  • Tongtan Liu,
  • Zengpeng Han and ,
  • Kunzhang Lin,
  • Qing Shi,
  • Ning Zheng,
  • Tao Ye,
  • Huinan Gong and
  • Fuqiang Xu
  • + 5 authors+ 0 author

Herpes simplex virus type 1 (HSV-1) is a leading cause of encephalitis and infectious blindness. The commonly used clinical therapeutic drugs are nucleoside analogues such as acyclovir. However, current drugs for HSV cannot eliminate the latent virus...

(This article belongs to the Section Viral Pathogens)
  • Communication
  • Open Access
2 Citations
2,266 Views
5 Pages

Equine Herpesvirus type 1 (EHV-1) typically causes mild respiratory disease, but it can also cause late-term abortion, neonatal foal death and neurologic disease. Once a horse is infected, the virus concentrates to local lymphoid tissue, where it bec...

(This article belongs to the Section Viral Pathogens)
  • Article
  • Open Access
12 Citations
2,406 Views
14 Pages

The early identification of the spreading patterns of an epidemic infectious disease is an important first step towards the adoption of effective interventions. We developed a simple regression-based method to estimate the directional speed of a dise...

(This article belongs to the Special Issue An Update on African Swine Fever)
  • Article
  • Open Access
8 Citations
2,899 Views
11 Pages

Improving African Swine Fever Surveillance Using Fluorescent Rapid Tests

  • Cristina Aira,
  • Alejandro Monedero,
  • Sonia Hernández-Antón,
  • Juan Martínez-Cano and ,
  • Ana Camuñas,
  • Nadia Casado,
  • Raquel Nieto,
  • Carmina Gallardo,
  • Marga García-Durán and
  • Alba Fresco-Taboada
  • + 6 authors+ 1 author

African swine fever (ASF) is a viral disease of swine with a huge impact due to its high mortality. Lately, the disease has actively spread around the world, affecting new areas from which it had been eradicated long ago. To date, ASF control is carr...

(This article belongs to the Special Issue Diagnostics of Animal Viral Infectious Diseases)
  • Review
  • Open Access
12 Citations
9,291 Views
25 Pages

This review presents the main cell characteristics altered after in vitro incubation of the parasite with commercial drugs used to treat the disease caused by Giardia intestinalis. This important intestinal parasite primarily causes diarrhea in child...

(This article belongs to the Section Parasitic Pathogens)
  • Article
  • Open Access
6 Citations
2,801 Views
17 Pages

Stage-Dependent Increase of Systemic Immune Activation and CCR5+CD4+ T Cells in Filarial Driven Lymphedema in Ghana and Tanzania

  • Abu Abudu Rahamani,
  • Sacha Horn,
  • Manuel Ritter,
  • Anja Feichtner and ,
  • Jubin Osei-Mensah,
  • Vera Serwaa Opoku,
  • Linda Batsa Debrah,
  • Thomas F. Marandu,
  • Antelmo Haule and
  • Inge Kroidl
  • + 14 authors+ 9 authors

Chronic lymphedema caused by infection of Wuchereria bancrofti is a disfiguring disease that leads to physical disability, stigmatization, and reduced quality of life. The edematous changes occur mainly on the lower extremities and can progress over...

(This article belongs to the Section Parasitic Pathogens)
  • Article
  • Open Access
6 Citations
3,039 Views
11 Pages

Secreted Extracellular Products of Flavobacterium covae as Potential Immunogenic Factors for Protection against Columnaris Disease in Channel Catfish (Ictalurus punctatus)

  • Mohamed Sayed,
  • Lakshmi Narayanan,
  • Manal Essa,
  • Mark Lawrence and ,
  • Attila Karsi and
  • Hossam Abdelhamed
  • + 1 author+ 0 author

Columnaris disease caused by Flavobacterium covae leads to substantial economic losses in commercially important fish species worldwide. The US channel catfish (Ictalurus punctatus) industry is particularly vulnerable to this disease. Therefore, ther...

(This article belongs to the Special Issue Emerging Infections in Aquatic Animals)
  • Article
  • Open Access
5 Citations
3,079 Views
18 Pages

Application of Cypermethrin-Coated ZnS and ZnO Nanoparticles against Rhipicephalus Ticks

  • Tean Zaheer,
  • Rao Zahid Abbas,
  • Nighat Perveen,
  • Olivier Andre Sparagano and ,
  • Shanza Rauf Khan,
  • Tauseef Ur Rehman,
  • Ali Raza,
  • Muhammad Kasib Khan and
  • Muhammad Imran Arshad
  • + 4 authors+ 0 author

Rhipicephalus ticks are described as important ticks impacting the costs of livestock rearing and by-products sale. The prevalence and response of ticks towards cypermethrin sprays indicate the need to implement the rational use of acaricides. In our...

  • Review
  • Open Access
7 Citations
7,368 Views
20 Pages

Despite what its name suggests, the effects of the COVID-19 pandemic causative agent “Severe Acute Respiratory Syndrome Coronavirus-2” (SARS-CoV-2) were not always confined, neither temporarily (being long-term rather than acute, referred...

(This article belongs to the Section Viral Pathogens)
  • Communication
  • Open Access
23 Citations
3,942 Views
9 Pages

ASF Vaccine Candidate ASFV-G-∆I177L Does Not Exhibit Residual Virulence in Long-Term Clinical Studies

  • Manuel V. Borca,
  • Elizabeth Ramirez-Medina,
  • Ediane Silva,
  • Ayushi Rai and ,
  • Nallely Espinoza,
  • Lauro Velazquez-Salinas and
  • Douglas P. Gladue
  • + 2 authors+ 0 author

African swine fever (ASF) is an important disease in swine currently producing a pandemic affecting pig production worldwide. Except in Vietnam, where two vaccines were recently approved for controlled use in the field, no vaccine is commercially ava...

(This article belongs to the Special Issue Emergence and Control of African Swine Fever)

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Pathogens - ISSN 2076-0817