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Journal of Personalized Medicine
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Journal of Personalized Medicine, Volume 8, Issue 2

June 2018 - 8 articles

Cover Story: Halladay et al. highlight how precision medicine in hypertension interventions apply to Eastern North Carolina rural populations. Coalescing experts in health services research, primary care, epidemiology, public health, and genetics, researchers were able to identify which blood pressure-related genetic variants were applicable to populations in this region. Additional images obtained from Pixabay.com under Creative Commons CCO from submitters GDJ and Clker-Free-Vector-Images. View this paper.
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Articles (8)

  • Conference Report
  • Open Access
8,135 Views
5 Pages
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ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 3: In Vitro to In Vivo: Modeling Life in 3D

  • Gianmarco Di Mauro,
  • Ambra Dondi,
  • Giovanni Giangreco,
  • Alexander Hogrebe,
  • Elja Louer,
  • Elisa Magistrati,
  • Meeli Mullari,
  • Gemma Turon,
  • Wouter Verdurmen and
  • Helena Xicoy Cortada
  • + 1 author
J. Pers. Med.2018, 8(2), 20;https://doi.org/10.3390/jpm8020020

22 May 2018

The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European research institutes (Institute for Research in Biomedicine—IRB Barcelona, Spain; Radboud In...

Full Article
  • Article
  • Open Access
39 Citations
10,498 Views
15 Pages
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Insurance Coverage Policies for Pharmacogenomic and Multi-Gene Testing for Cancer

  • Christine Y. Lu,
  • Stephanie Loomer,
  • Rachel Ceccarelli,
  • Kathleen M. Mazor,
  • James Sabin,
  • Ellen Wright Clayton,
  • Geoffrey S. Ginsburg and
  • Ann Chen Wu
J. Pers. Med.2018, 8(2), 19;https://doi.org/10.3390/jpm8020019

16 May 2018

Insurance coverage policies are a major determinant of patient access to genomic tests. The objective of this study was to examine differences in coverage policies for guideline-recommended pharmacogenomic tests that inform cancer treatment. We analy...

Full Article
  • Article
  • Open Access
5 Citations
10,023 Views
21 Pages
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Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations

  • Jacqueline R. Halladay,
  • Kaitlin C. Lenhart,
  • Kimberly Robasky,
  • Wendell Jones,
  • Wayne F. Homan,
  • Doyle M. Cummings,
  • Crystal W. Cené,
  • Alan L. Hinderliter,
  • Cassandra L. Miller and
  • Katrina E. Donahue
  • + 8 authors
J. Pers. Med.2018, 8(2), 16;https://doi.org/10.3390/jpm8020016

30 April 2018

As part of the Heart Healthy Lenoir Project, we developed a practice level intervention to improve blood pressure control. The goal of this study was: (i) to determine if single nucleotide polymorphisms (SNPs) that associate with blood pressure varia...

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  • Feature Paper
  • Review
  • Open Access
117 Citations
14,297 Views
15 Pages
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Ten Years’ Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics

  • Andrea Gaedigk,
  • Jean C. Dinh,
  • Hyunyoung Jeong,
  • Bhagwat Prasad and
  • J. Steven Leeder
J. Pers. Med.2018, 8(2), 15;https://doi.org/10.3390/jpm8020015

17 April 2018

The seminal paper on the CYP2D6 Activity Score (AS) was first published ten years ago and, since its introduction in 2008, it has been widely accepted in the field of pharmacogenetics. This scoring system facilitates the translation of highly complex...

Full Article
  • Feature Paper
  • Review
  • Open Access
39 Citations
11,038 Views
27 Pages
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Genetic Heterogeneity of SLC22 Family of Transporters in Drug Disposition

  • Elisa Lozano,
  • Oscar Briz,
  • Rocio I. R. Macias,
  • Maria A. Serrano,
  • Jose J. G. Marin and
  • Elisa Herraez
J. Pers. Med.2018, 8(2), 14;https://doi.org/10.3390/jpm8020014

16 April 2018

An important aspect of modern medicine is its orientation to achieve more personalized pharmacological treatments. In this context, transporters involved in drug disposition have gained well-justified attention. Owing to its broad spectrum of substra...

Full Article
  • Article
  • Open Access
6 Citations
9,652 Views
22 Pages
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Genomic Profiling on an Unselected Solid Tumor Population Reveals a Highly Mutated Wnt/β-Catenin Pathway Associated with Oncogenic EGFR Mutations

  • Jingrui Jiang,
  • Alexei Protopopov,
  • Ruobai Sun,
  • Stephen Lyle and
  • Meaghan Russell
J. Pers. Med.2018, 8(2), 13;https://doi.org/10.3390/jpm8020013

9 April 2018

Oncogenic epidermal growth factor receptors (EGFRs) can recruit key effectors in diverse cellular processes to propagate oncogenic signals. Targeted and combinational therapeutic strategies have been successfully applied for treating EGFR-driven canc...

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J. Pers. Med. - ISSN 2075-4426
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