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Journal of Personalized Medicine, Volume 14, Issue 5

May 2024 - 105 articles

Cover Story: Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological and psychiatric health. It exerts a profound effect on immune cell activation and brain function, suggesting potential roles in both neuroprotection and neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation and disease progression. Additionally, CXCL8 gene polymorphisms can alter IL-8 production, leading to potential differences in disease susceptibility, progression, and severity across populations. IL-8 levels vary among neuropsychiatric conditions, demonstrating sensitivity to psychosocial stressors and disease severity. IL-8 can be detected in blood circulation, cerebrospinal fluid (CSF), and urine, making it a promising candidate for a broad-spectrum biomarker. View this paper
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Articles (105)

  • Review
  • Open Access
18 Citations
7,768 Views
21 Pages

Review: A Contemporary, Multifaced Insight into Psoriasis Pathogenesis

  • Rucsandra Cristina Dascălu,
  • Andreea Lili Bărbulescu,
  • Loredana Elena Stoica,
  • Ștefan Cristian Dinescu,
  • Cristina Elena Biță,
  • Horațiu Valeriu Popoviciu,
  • Răzvan Adrian Ionescu and
  • Florentin Ananu Vreju

Psoriasis is a chronic recurrent inflammatory autoimmune pathology with a significant genetic component and several interferences of immunological cells and their cytokines. The complex orchestration of psoriasis pathogenesis is related to the synerg...

  • Article
  • Open Access
6 Citations
2,559 Views
14 Pages

Machine Learning Modeling to Predict Atrial Fibrillation Detection in Embolic Stroke of Undetermined Source Patients

  • Chua Ming,
  • Geraldine J. W. Lee,
  • Yao Hao Teo,
  • Yao Neng Teo,
  • Emma M. S. Toh,
  • Tony Y. W. Li,
  • Chloe Yitian Guo,
  • Jiayan Ding,
  • Xinyan Zhou and
  • Hock Luen Teoh
  • + 6 authors

Background: In patients with embolic stroke of undetermined source (ESUS), occult atrial fibrillation (AF) has been implicated as a key source of cardioembolism. However, only a minority acquire implantable cardiac loop recorders (ILRs) to detect occ...

  • Article
  • Open Access
4 Citations
4,756 Views
14 Pages

A Grounded Theory of Interdisciplinary Communication and Collaboration in the Outpatient Setting of the Hospital for Patients with Multiple Long-Term Conditions

  • Emma A. Gans,
  • Ursula W. de Ruijter,
  • Agnes van der Heide,
  • Suzanne A. van der Meijden,
  • Frederiek van den Bos,
  • Barbara C. van Munster and
  • Janke F. de Groot

Interdisciplinary communication and collaboration are crucial in the care of people with multiple long-term conditions (MLTCs) yet are often experienced as insufficient. Through the lens of complexity science, this study aims to explain how healthcar...

  • Article
  • Open Access
3 Citations
2,663 Views
11 Pages

Upper airway collapse and apneas in obstructive sleep apnea (OSA) induce intermittent hypercapnia and hypoxia, eventually contributing to excessive uric acid production. This study aimed to evaluate the association between hyperuricemia and OSA in th...

  • Article
  • Open Access
5 Citations
2,067 Views
11 Pages

Background: Sepsis remains a major health challenge worldwide, characterized by a dysregulated host response to infection, leading to high mortality and morbidity in intensive care units (ICUs). The Fibrosis 4 (FIB-4) index, originally developed to a...

  • Article
  • Open Access
2 Citations
4,879 Views
9 Pages

Iris Pigmented Lesions and Risk of Cutaneous Melanoma: Case–Control Study in Lithuania

  • Lukas Šemeklis,
  • Laura Kapitanovaitė,
  • Grinvydas Butrimas,
  • Kamilija Briedė,
  • Augustė Dubinskaitė,
  • Reda Žemaitienė and
  • Skaidra Valiukevičienė

The global incidence of cutaneous melanoma (CM) is rising, necessitating early detection and identification of risk factors across different populations. A case–control study with 180 patients with primary diagnosed CM and 182 healthy controls...

  • Article
  • Open Access
2 Citations
1,750 Views
11 Pages

Awareness of Proton Pump Inhibitor Adverse Events and Treatment Pattern Change According to Physician Practice: A National Questionnaire Study in Korea

  • Yong Hoon Choi,
  • Seung In Seo,
  • Da Hyun Jung,
  • Joon Sung Kim,
  • Seung Young Kim,
  • Hyun Chul Lim and
  • Young Hoon Youn

Although adverse events of proton pump inhibitors (PPIs) have been reported, there are few studies on physicians’ perceptions. We aimed to investigate physicians’ awareness of PPI-related adverse events and changes in treatment patterns a...

  • Article
  • Open Access
2 Citations
2,202 Views
13 Pages

Minimally Invasive Isolated and Hybrid Surgical Revascularization for Multivessel Coronary Disease: A Single-Center Long-Term Follow-Up

  • Tiziano Torre,
  • Alberto Pozzoli,
  • Marco Valgimigli,
  • Laura Anna Leo,
  • Francesca Toto,
  • Mirko Muretti,
  • Sara Birova,
  • Enrico Ferrari,
  • Giovanni Pedrazzini and
  • Stefanos Demertzis

Introduction: Some evidence suggests that surgical minimally invasive (MIDCAB) and hybrid coronary revascularization (HCR) are safe and potentially effective at short-term follow-up. Data on long-term outcomes are more limited and inconclusive. Metho...

  • Article
  • Open Access
1 Citations
1,863 Views
15 Pages

Evaluation of Immunohistochemical Biomarkers in Diabetic Wistar Rats with Periodontal Disease

  • Ioana Scrobota,
  • Ioan Andrei Tig,
  • Andrea Olivia Marcu,
  • Georgiana Ioana Potra Cicalau,
  • Liliana Sachelarie and
  • Gilda Iova

Background: The association of periodontal disease and diabetes is a subject of intense research in terms of etiopathology and treatment options. This research aimed to evaluate the modulation of the local inflammatory status by two natural extracts,...

  • Article
  • Open Access
1,895 Views
12 Pages

The Galilee region of Israel boasts a rich ethnic diversity within its Arab population, encompassing distinct Muslim, Christian, Druze, and Bedouin communities. This preliminary exploratory study uniquely examined potential ethnic and gender differen...

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J. Pers. Med. - ISSN 2075-4426