Precision Medicine for Digestive Diseases

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 4232

Special Issue Editors


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Guest Editor
Department of Oncology, Fundeni Clinical Institute, 022328 Bucharest, Romania
Interests: clinical oncology; digestive oncology; cancer diagnostics and treatments; cancer biomarkers; clonal hematopoiesis
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Oncology, Fundeni Clinical Institute, 022328 Bucharest, Romania
2. Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: digestive oncology; cancer biomarkers; cancer screening; pancreatic cancer; clonal hematopoiesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Precision medicine in gastrointestinal cancers represents a significant shift towards more personalized healthcare, with the potential to improve outcomes, reduce unnecessary treatments, and enhance the quality of life for patients with these complex diseases.

Gastrointestinal cancers, encompassing a diverse group of malignancies including esophageal, gastric, colorectal, pancreatic, liver, and biliary tract, remain a significant challenge worldwide due to their high incidence, mortality rates, and complex biological behaviors. Currently, several biomarkers predictive of prognosis or drug response have been suggested for patients with digestive cancers and their detection in tissue or liquid biopsies has the potential to improve clinical practice. This Special Issue is designed to provide information on new biomarker research in the area of gastrointestinal tumors that could be useful for individualized care. Furthermore, this Special Issue aims to explore how precision medicine can revolutionize the management of these cancers, from early detection and diagnosis to treatment and beyond.

Contributions may include original research articles, review papers, and perspectives from leading experts in the field. We encourage submissions from a multidisciplinary team of authors, reflecting the collaborative nature of precision medicine.

Dr. Adina Emilia Croitoru
Dr. Irina M. Cazacu
Guest Editors

Manuscript Submission Information

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Keywords

  • colorectal cancer
  • esophageal cancer
  • gastric cancer
  • pancreatic cancer
  • liver and biliary tract cancer
  • biomarkers
  • tissue biopsy
  • liquid biopsy
  • precision medicine

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Published Papers (2 papers)

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Review

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12 pages, 539 KiB  
Review
Dynamics of RAS Mutations in Liquid Biopsies in Metastatic Colorectal Cancer Patients—Case Series and Literature Review
by Ionut Popescu, Vlad M. Croitoru, Irina M. Croitoru-Cazacu, Ana-Maria Dudau, Vlad Herlea, Simona Olimpia Dima and Adina Emilia Croitoru
J. Pers. Med. 2024, 14(7), 750; https://doi.org/10.3390/jpm14070750 - 15 Jul 2024
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Abstract
Liquid biopsies can accurately identify molecular alterations in patients with colorectal cancer with high concordance with tissue analysis and shorter turnaround times. Circulating tumor (ct) DNA analysis can be used for diagnosing and monitoring tumor evolution in patients with metastatic colorectal cancer who [...] Read more.
Liquid biopsies can accurately identify molecular alterations in patients with colorectal cancer with high concordance with tissue analysis and shorter turnaround times. Circulating tumor (ct) DNA analysis can be used for diagnosing and monitoring tumor evolution in patients with metastatic colorectal cancer who are treated with EGFR inhibitors. In this article, we reported three clinical cases to illustrate the relevance of RAS mutations identified in ctDNA samples of patients with wild-type metastatic colorectal cancer who received an EGFR inhibitor plus chemotherapy as first-line treatment. The identification of RAS mutations in these patients is one of the most frequently identified mechanisms of acquired resistance. However, detecting a KRAS mutation via liquid biopsy can be caused by inter-tumor heterogeneity or it can be a false positive due to clonal hematopoiesis. More research is needed to determine whether ctDNA monitoring may help guide therapy options in metastatic colorectal cancer patients. We performed a literature review to assess the technologies that are used for analysis of RAS mutations on ctDNA, the degree of agreement between tissue and plasma and the importance of tissue/plasma discordant cases. Full article
(This article belongs to the Special Issue Precision Medicine for Digestive Diseases)
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16 pages, 1270 KiB  
Systematic Review
Clinical Outcome of Colorectal Cancer Patients with Concomitant Hypertension: A Systematic Review and Meta-Analysis
by Daniel Sur, Constantin Ionut Coroama, Alessandro Audisio, Roberta Fazio, Maria Coroama and Cristian Virgil Lungulescu
J. Pers. Med. 2024, 14(5), 520; https://doi.org/10.3390/jpm14050520 - 14 May 2024
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Abstract
Background: Arterial hypertension is regarded as a possible biomarker of treatment efficacy in colorectal cancer. Also, extended anti-angiogenic use in the metastatic treatment of the colorectal neoplasm may result in elevated blood pressure. We carried out a systematic review and meta-analysis to assess [...] Read more.
Background: Arterial hypertension is regarded as a possible biomarker of treatment efficacy in colorectal cancer. Also, extended anti-angiogenic use in the metastatic treatment of the colorectal neoplasm may result in elevated blood pressure. We carried out a systematic review and meta-analysis to assess the clinical outcome of colorectal cancer patients with concomitant hypertension (HTN). Methods: We conducted a systematic search on Embase, Web of Science, Scopus, PubMed (Medline), the Cochrane Library, and CINAHL from inception until October 2023 for articles that addressed the relationship between HTN and progressive free survival (PFS), overall survival (OS), and overall response rate (ORR) for the first and second line of systemic therapy in patients with metastatic colorectal cancer. Results: Eligibility criteria were met by 16 articles out of 802 screened studies. Pooled analysis showed that HTN was associated with significantly improved PFS (HR: 0.507, 95% CI: 0.460–0.558, p ≤ 0.001) and OS (HR: 0.677, 95% CI: 0.592–0.774, p ≤ 0.001) in patients with metastatic colorectal cancer. In addition, the pooled RR of HTN for the ORR (RR: 1.28, 95% CI: 1.108–1.495, p = 0.001) suggests that HTN could be a predictive factor of ORR in patients with metastatic colorectal cancer. Conclusions: Elevated blood pressure is associated with better clinical outcomes in patients with metastatic colorectal cancer. Full article
(This article belongs to the Special Issue Precision Medicine for Digestive Diseases)
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