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Journal of Personalized Medicine, Volume 14, Issue 6

2024 June - 118 articles

Cover Story: The shift towards personalized cancer medicine (PCM) represents a significant transformation in cancer care, emphasizing tailored treatments based on the genetic understanding of cancer at the cellular level. This review draws on the recent literature to explore key factors influencing PCM implementation, highlighting the role of innovative leadership, interdisciplinary collaboration, and coordinated funding and regulatory strategies. Success in PCM relies on overcoming challenges such as integrating diverse medical disciplines, securing sustainable investment for shared infrastructures, and navigating complex regulatory landscapes. Effective leadership fosters a culture of innovation and teamwork, which is essential for translating complex biological insights into personalized treatment strategies. View this paper
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Articles (118)

  • Article
  • Open Access
2,143 Views
11 Pages

20 June 2024

The rotational alignment of the femoral component in total knee arthroplasty (TKA) is considered an important factor, but it is still difficult to assess intraoperatively. This study was conducted to identify anatomical parameters for femoral rotatio...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Review
  • Open Access
6 Citations
6,419 Views
15 Pages

20 June 2024

Fibromyalgia and osteoarthritis are among the most prevalent rheumatic conditions worldwide. Nonpharmacological interventions have gained scientific endorsements as the preferred initial treatments before resorting to pharmacological modalities. Repe...

(This article belongs to the Special Issue Musculoskeletal Diseases: Aetiology, Clinical Implications, Rehabilitation and Treatment)
  • Article
  • Open Access
2 Citations
3,315 Views
10 Pages

Calcium-Free Dialysate Hemodialysis: A Simplified Approach

  • Alexandra Corbu,
  • Florian Terrec,
  • Paolo Malvezzi,
  • Arnaud Jouzier,
  • Thomas Jouve,
  • Lionel Rostaing and
  • Hamza Naciri Bennani

20 June 2024

Intermittent hemodialysis (HD) in high-bleeding-risk patients presents a challenge as circuit anticoagulation using heparin is contraindicated in such cases. Recently, the use of calcium-free citrate-containing dialysate with calcium supplementation...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Article
  • Open Access
5 Citations
4,993 Views
10 Pages

Chronic Pelvic Pain in Congestion Pelvic Syndrome: Clinical Impact and Electromyography Pelvic Floor Activity Prior to and after Endovascular Treatment

  • Fabio Corvino,
  • Francesco Giurazza,
  • Milena Coppola,
  • Antonio Tomasello,
  • Francesco Coletta,
  • Crescenzo Sala,
  • Romolo Villani,
  • Bernardo Maria de Martino,
  • Antonio Corvino and
  • Raffaella Niola

20 June 2024

Background: This study aims to characterize the clinical impact of endovascular treatment in Chronic Pelvic Pain (CPP) patients due to Pelvic Congestion Syndrome (PCS) and to assess the diagnostic value of surface electromyography (sEMG) studies of p...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
2 Citations
4,020 Views
11 Pages

20 June 2024

Posterior spinal fusion for adolescent idiopathic scoliosis (AIS) causes severe postoperative pain. Thoracic paravertebral block (PVB) provides excellent analgesia during various surgeries. We examined the effects of PVB on postoperative analgesia in...

(This article belongs to the Special Issue Anesthesiology and Pain Management in Clinical Medicine)
  • Article
  • Open Access
4 Citations
1,827 Views
12 Pages

Prediction of Cesarean Section for Intrapartum Fetal Compromise: A Multivariable Model from a Prospective Observational Approach

  • Blanca Novillo-Del Álamo,
  • Alicia Martínez-Varea,
  • Mar Nieto-Tous,
  • Carmen Padilla-Prieto,
  • Fernando Modrego-Pardo,
  • Silvia Bello-Martínez de Velasco,
  • María Victoria García-Florenciano and
  • José Morales-Roselló

20 June 2024

Objective: A cesarean section for intrapartum fetal compromise (IFC) is performed to avoid potential damage to the newborn. It is, therefore, crucial to develop an accurate prediction model that can anticipate, prior to labor, which fetus may be at r...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Article
  • Open Access
1 Citations
2,068 Views
11 Pages

Clinical Characteristics and Prognosis of Older Patients with Coronavirus Disease 2019 Requiring Mechanical Ventilation

  • Green Hong,
  • Da Hyun Kang,
  • Sunghoon Park,
  • Su Hwan Lee,
  • Onyu Park,
  • Taehwa Kim,
  • Hye Ju Yeo,
  • Jin Ho Jang,
  • Woo Hyun Cho and
  • Song I Lee

19 June 2024

An older age is associated with severe progression and poor prognosis in coronavirus disease 2019 (COVID-19), and mechanical ventilation is often required. The specific characteristics of older patients undergoing mechanical ventilation and their pro...

(This article belongs to the Special Issue Respiratory and Emergency Medicine)
  • Review
  • Open Access
16 Citations
6,243 Views
15 Pages

Future Horizons: The Potential Role of Artificial Intelligence in Cardiology

  • Octavian Stefan Patrascanu,
  • Dana Tutunaru,
  • Carmina Liana Musat,
  • Oana Maria Dragostin,
  • Ana Fulga,
  • Luiza Nechita,
  • Alexandru Bogdan Ciubara,
  • Alin Ionut Piraianu,
  • Elena Stamate and
  • Iuliu Fulga
  • + 4 authors

19 June 2024

Cardiovascular diseases (CVDs) are the leading cause of premature death and disability globally, leading to significant increases in healthcare costs and economic strains. Artificial intelligence (AI) is emerging as a crucial technology in this conte...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Review
  • Open Access
26 Citations
7,199 Views
20 Pages

19 June 2024

Background/Objectives: Temporomandibular disorder (TMD) is the term used to describe a pathology (dysfunction and pain) in the masticatory muscles and temporomandibular joint (TMJ). There is an apparent upward trend in the publication of dental resea...

(This article belongs to the Special Issue Personalized Medicine in Dental and Oral Health)
  • Systematic Review
  • Open Access
11 Citations
5,722 Views
28 Pages

The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

  • Odysseas Violetis,
  • Panagiota Konstantakou,
  • Ariadni Spyroglou,
  • Antonios Xydakis,
  • Panagiotis B. Kekis,
  • Sofia Tseleni,
  • Denise Kolomodi,
  • Manousos Konstadoulakis,
  • George Mastorakos and
  • Krystallenia I. Alexandraki
  • + 2 authors

18 June 2024

Background: Poorly differentiated thyroid carcinoma (PDTC) has an intermediate prognosis between indolent well-differentiated thyroid carcinoma (TC) and anaplastic carcinoma. Herein, we present a case report with a PDTC component, along with a system...

(This article belongs to the Section Molecular Targeted Therapy)
  • Review
  • Open Access
13 Citations
10,749 Views
21 Pages

The Role of Oral Supplementation for the Management of Age-Related Macular Degeneration: A Narrative Review

  • Angela D’Angelo,
  • Livio Vitiello,
  • Vincenzo Gagliardi,
  • Giulio Salerno,
  • Ilaria De Pascale,
  • Alessia Coppola,
  • Giulia Abbinante,
  • Alfonso Pellegrino and
  • Giuseppe Giannaccare

18 June 2024

The majority of neurodegenerative eye disorders occur with aging and significantly impair quality of life. Age-related macular degeneration (AMD) is the third most common cause of visual impairment and blindness worldwide. One of the most important e...

(This article belongs to the Special Issue New Advances and Perspectives in Ophthalmology: Progress and Modern Challenges)
  • Article
  • Open Access
2 Citations
2,358 Views
15 Pages

Mobile App for Enhanced Anterior Cruciate Ligament (ACL) Assessment in Conscious Subjects: “Pivot-Shift Meter”

  • Edmundo Berumen-Nafarrate,
  • Ivan Rene Ramos-Moctezuma,
  • Luis Raúl Sigala-González,
  • Fatima Norely Quintana-Trejo,
  • Jesus Javier Tonche-Ramos,
  • Nadia Karina Portillo-Ortiz,
  • Carlos Eduardo Cañedo-Figueroa and
  • Arturo Aguirre-Madrid

18 June 2024

Anterior cruciate ligament (ACL) instability poses a considerable challenge in traumatology and orthopedic medicine, demanding precise diagnostics for optimal treatment. The pivot-shift test, a pivotal assessment tool, relies on subjective interpreta...

(This article belongs to the Topic Orthopaedic Diseases and Innovative Intervention Strategies, 2nd Volume)
  • Article
  • Open Access
15 Citations
5,835 Views
16 Pages

The Role of the Gut Microbiome in Inflammatory Bowel Disease: The Middle East Perspective

  • Ahmed El-Sayed,
  • Diya Kapila,
  • Rama Sami Issa Taha,
  • Sherif El-Sayed,
  • Mohd Rafiw Ahmed Mahen,
  • Roa’a Taha and
  • Laith Alrubaiy

18 June 2024

The gut microbiome is of paramount importance in preserving internal balance in the gastrointestinal tract; therefore, disruptions in its regulation have been linked to the development of inflammatory bowel disease (IBD). This article explores the in...

(This article belongs to the Section Disease Biomarkers)
  • Article
  • Open Access
28 Citations
14,952 Views
13 Pages

Assessing Nutritional Deficiencies in Bariatric Surgery Patients: A Comparative Study of Roux-en-Y Gastric Bypass versus Sleeve Gastrectomy

  • José P. Vieira de Sousa,
  • Hugo Santos-Sousa,
  • Sofia Vieira,
  • Rita Nunes,
  • Jorge Nogueiro,
  • André Pereira,
  • Fernando Resende,
  • André Costa-Pinho,
  • John Preto and
  • Eduardo Lima-da-Costa
  • + 2 authors

18 June 2024

Obesity is a worldwide epidemic, and bariatric surgery is considered the primary treatment for long-term weight loss and managing obesity-related health issues. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are the most performed proced...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
1 Citations
2,961 Views
11 Pages

A Genome-Wide Association Study of Oxypurinol Concentrations in Patients Treated with Allopurinol

  • Maxime Meloche,
  • Marc-Olivier Pilon,
  • Sylvie Provost,
  • Grégoire Leclair,
  • Essaïd Oussaïd,
  • Isabelle St-Jean,
  • Martin Jutras,
  • Marie-Josée Gaulin,
  • Louis-Philippe Lemieux Perreault and
  • Simon de Denus
  • + 6 authors

18 June 2024

Cohort studies have identified several genetic determinants that could predict the clinical response to allopurinol. However, they have not been commonly used for genome-wide investigations to identify genetic determinants on allopurinol metabolism a...

(This article belongs to the Section Pharmacogenetics)
  • Communication
  • Open Access
2,685 Views
15 Pages

SwissGenVar: A Platform for Clinical-Grade Interpretation of Genetic Variants to Foster Personalized Healthcare in Switzerland

  • Dennis Kraemer,
  • Dillenn Terumalai,
  • Maria Livia Famiglietti,
  • Isabel Filges,
  • Pascal Joset,
  • Samuel Koller,
  • Fabienne Maurer,
  • Stéphanie Meier,
  • Thierry Nouspikel and
  • Anita Rauch
  • + 8 authors

17 June 2024

Large-scale next-generation sequencing (NGS) germline testing is technically feasible today, but variant interpretation represents a major bottleneck in analysis workflows. This includes extensive variant prioritization, annotation, and time-consumin...

(This article belongs to the Topic Public Health and Healthcare in the Context of Big Data)
  • Review
  • Open Access
7 Citations
3,910 Views
15 Pages

Artificial Intelligence Used for Diagnosis in Facial Deformities: A Systematic Review

  • Victor Ravelo,
  • Julio Acero,
  • Jorge Fuentes-Zambrano,
  • Henry García Guevara and
  • Sergio Olate

17 June 2024

AI is included in a lot of different systems. In facial surgery, there are some AI-based software programs oriented to diagnosis in facial surgery. This study aims to evaluate the capacity and training of models for diagnosis of dentofacial deformiti...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
2,218 Views
16 Pages

The Relationship between the Laboratory Biomarkers of SARS-CoV-2 Patients with Type 2 Diabetes at Discharge and the Severity of the Viral Pathology

  • Patricia-Andrada Reștea,
  • Ștefan Țigan,
  • Laura Grațiela Vicaș,
  • Luminita Fritea,
  • Mariana Eugenia Mureșan,
  • Felicia Manole and
  • Daniela Elisabeta Berdea

17 June 2024

In this study, we evaluated the discharge status of patients with type 2 diabetes mellitus and SARS-CoV-2 infection, focusing on the inflammatory profile through biomarkers such as procalcitonin, CRP, LDH, fibrinogen, ESR, and ferritin, as well as el...

(This article belongs to the Section Disease Biomarkers)
  • Brief Report
  • Open Access
7 Citations
2,574 Views
11 Pages

Effects of NF-κB Inhibitor on Sepsis Depend on the Severity and Phase of the Animal Sepsis Model

  • Ye Jin Park,
  • Jinkun Bae,
  • Jae-Kwang Yoo,
  • So-Hee Ahn,
  • Seon Young Park,
  • Yun-Seok Kim,
  • Min Ji Lee,
  • Seon Young Moon,
  • Tae Nyoung Chung and
  • Kyuseok Kim
  • + 1 author

17 June 2024

Hyperinflammation occurs in sepsis, especially in the early phase, and it could have both positive and negative effects on sepsis. Previously, we showed that a new concept of NF-κB inhibitor, exosome-based super-repressor IκBα (Exo-...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Review
  • Open Access
4 Citations
3,629 Views
10 Pages

Unveiling the Hidden Perils: A Comprehensive Review of Fungal Infections in Inflatable Penile Prosthesis Surgery

  • Anastasios Natsos,
  • Vasileios Tatanis,
  • Alexandra Lekkou,
  • Stavros Kontogiannis,
  • Athanasios Vagionis,
  • Theodoros Spinos,
  • Angelis Peteinaris,
  • Mohammed Obaidat,
  • Konstantinos Pagonis and
  • Petros Drettas
  • + 2 authors

16 June 2024

Inflatable penile prosthesis (IPP) surgery is an effective treatment for erectile dysfunction (ED), but infections pose a significant threat to its success. Current guidelines lack antifungal recommendations, despite rising fungal infection rates pos...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Article
  • Open Access
2 Citations
2,958 Views
12 Pages

16 June 2024

Despite advancements in artificial intelligence-based decision-making, transitioning patients from intensive care units (ICUs) to low-acuity wards is challenging, especially in resource-limited settings. This study aimed to develop a simple scoring s...

(This article belongs to the Special Issue New Perspectives of Critical Care Medicine)
  • Article
  • Open Access
2 Citations
2,158 Views
11 Pages

16 June 2024

The beach chair position (BCP) is widely used in shoulder surgery; however, it frequently leads to hypotension. Hypotension in BCP is prevalent among older patients who are at risk of secondary complications such as ischemic injuries. Therefore, this...

(This article belongs to the Special Issue Anesthesiology and Pain Management in Clinical Medicine)
  • Case Report
  • Open Access
5 Citations
75,685 Views
16 Pages

Reversal of Autism Symptoms among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature

  • Christopher R. D’Adamo,
  • Josephine L. Nelson,
  • Sara N. Miller,
  • Maria Rickert Hong,
  • Elizabeth Lambert and
  • Heather Tallman Ruhm

15 June 2024

The prevalence of autism has been increasing at an alarming rate. Even accounting for the expansion of autism spectrum disorder diagnostic (ASD) criteria throughout the 1990’s, there has been an over 300% increase in ASD prevalence since the ye...

(This article belongs to the Special Issue A Personalized Medicine Approach to the Diagnosis and Management of Autism Spectrum Disorder: Beyond Genetic Syndromes)
  • Case Report
  • Open Access
2 Citations
3,035 Views
8 Pages

Genomic and Transcriptomic Analysis of a Patient with Early-Onset Colorectal Cancer and Therapy-Induced Focal Nodular Hyperplasia: A Case Report

  • Mary O’Reilly,
  • Aleksandar Krstic,
  • Luis F. Iglesias-Martinez,
  • Éanna J. Ryan,
  • Bruce Moran,
  • Des Winter,
  • Kieran Sheahan,
  • Ray McDermott and
  • Walter Kolch

15 June 2024

Early-onset colorectal cancer (EOCRC), defined as colorectal cancer in individuals under 50 years of age, has shown an alarming increase in incidence worldwide. We report a case of a twenty-four-year-old female with a strong family history of colorec...

(This article belongs to the Section Pharmacogenetics)
  • Communication
  • Open Access
1 Citations
3,538 Views
8 Pages

Therapeutic Apheresis Using a β2-Microglobulin Removal Column Reduces Circulating Tumor Cell Count

  • Yasuo Komura,
  • Shintarou Kimura,
  • Ayana Takaura,
  • Yumi Hirasawa,
  • Katsunori Segawa,
  • Hiromi Muranishi,
  • Osamu Imataki,
  • Yoshihisa Kumayama and
  • Koichiro Homma

15 June 2024

An elevated serum β2-microglobulin (β2M) level is indicative of impaired glomerular filtration and prerenal diseases, such as malignant tumors, autoimmune disorders, and liver diseases. An elevated serum β2M level has been shown to pro...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Case Report
  • Open Access
6 Citations
4,324 Views
19 Pages

The Weight of Bariatric Surgery: Wernicke–Korsakoff Syndrome after Vertical Sleeve Gastrectomy—A Case Series

  • Melissa Gutiérrez-Rey,
  • Lily Castellar-Visbal,
  • Kaleb Acevedo-Vergara,
  • José Vargas-Manotas,
  • Diego Rivera-Porras,
  • Gloria Londoño-Juliao,
  • Brenda Castillo-Guerrero,
  • María-Camila Perdomo-Jiménez and
  • Valmore Bermúdez

14 June 2024

In this case series, the simultaneous occurrence of Wernicke’s encephalopathy (WE) and dry beriberi was reported in three patients who underwent vertical sleeve gastrectomy (VSG) between May 2021 and May 2023. All patients were obese women who...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
5 Citations
5,380 Views
13 Pages

Clinical High-Resolution Imaging of the Inner Ear by Using Magnetic Resonance Imaging (MRI) and Cone Beam Computed Tomography (CBCT)

  • Tomislav Santek,
  • Erich Hofmann,
  • Christian Milewski,
  • Konrad Schwager and
  • Andreas Prescher

14 June 2024

Purpose: Imaging of the delicate inner ear morphology has become more and more precise owing to the rapid progress in magnetic resonance imaging (MRI). However, in clinical practice, the interpretation of imaging findings is hampered by a limited kno...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Review
  • Open Access
1 Citations
5,366 Views
15 Pages

ATP-Binding Cassette Transporter of Clinical Significance: Sideroblastic Anemia

  • John O. Ogunbileje,
  • Neil Harris,
  • Tung Wynn,
  • Reema Kashif,
  • Brian Stover and
  • Bremansu Osa-Andrews

14 June 2024

The ATP-binding cassette (ABC) transporters are a vast group of 48 membrane proteins, some of which are of notable physiological and clinical importance. Some ABC transporters are involved in functions such as the transport of chloride ions, bilirubi...

(This article belongs to the Section Pharmacogenetics)
  • Article
  • Open Access
1 Citations
1,687 Views
15 Pages

Low-Carbon Monoxide Diffusing Capacity, Patient-Reported Measures and Reduced Nailfold Capillary Density Are Associated with Interstitial Lung Disease in Systemic Sclerosis

  • Rossella De Angelis,
  • Edoardo Cipolletta,
  • Francesca Francioso,
  • Marina Carotti,
  • Sonia Farah,
  • Andrea Giovagnoni and
  • Fausto Salaffi

14 June 2024

The aim of this paper is to identify factors associated with interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) and build an algorithm to better define this association for a personalised application in clinical practice. Metho...

(This article belongs to the Special Issue Personalized Medicine for Rheumatic Diseases)
  • Article
  • Open Access
3 Citations
7,177 Views
13 Pages

Gynecological Laparoscopic Surgeries under Spinal Anesthesia: Benefits and Challenges

  • Attila L. Major,
  • Kudrat Jumaniyazov,
  • Ruslan Jabbarov,
  • Mehdi Razzaghi and
  • Ivanna Mayboroda

14 June 2024

Objective: This prospective study investigated the feasibility of performing laparoscopic pelvic surgery under spinal anesthesia and analyzed the intraoperative side effects, like pain, nausea, and vomitus, of 915 patients. Methods: The implementatio...

(This article belongs to the Special Issue Interdisciplinary Approach and Personalized Therapy for Gynecological Disease)
  • Review
  • Open Access
3 Citations
2,546 Views
18 Pages

Value-Based Health Care Implementation: The Case Study of mTBI Biomarkers

  • Martina Zibetti,
  • Chiara Di Resta,
  • Giuseppe Banfi and
  • Rossella Tomaiuolo

14 June 2024

Traumatic brain injury is a significant global health issue, affecting approximately 69 million people annually. Early diagnosis is crucial for effective management, and biomarkers provide a promising approach to identifying traumatic brain injury in...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Article
  • Open Access
8 Citations
3,648 Views
12 Pages

13 June 2024

Limited knowledge is available about the association between autistic spectrum disorder (ASD) and precocious puberty. Our study examined the association between the two medical conditions and effect modification by sex and neuropsychiatric comorbidit...

(This article belongs to the Section Sex, Gender and Hormone Based Medicine)
  • Article
  • Open Access
2 Citations
2,130 Views
21 Pages

Surgical Management of Patients with Parotid Involvement from Non-Melanoma Skin Cancer of the Head and Neck

  • Filippo Carta,
  • Simone Corrias,
  • Melania Tatti,
  • Valeria Marrosu,
  • Mauro Bontempi,
  • Cinzia Mariani,
  • Clara Gerosa,
  • Caterina Ferreli,
  • Matteo Atzeni and
  • Roberto Puxeddu
  • + 2 authors

13 June 2024

We conducted a retrospective, longitudinal study on a single-center series of patients who underwent parotidectomy in the management of advanced head and neck non-melanoma skin cancer (hnNMSC). The aim of this study was to identify prognostic factors...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
1 Citations
1,696 Views
9 Pages

Ultrasonographic Synovitis Is Associated with the Development of Joint Destruction in Patients with Psoriatic Arthritis

  • Yutaro Yamada,
  • Kentaro Inui,
  • Koji Mandai,
  • Kenji Mamoto,
  • Tatsuya Koike,
  • Chiharu Tateishi,
  • Daisuke Tsuruta and
  • Tadashi Okano

13 June 2024

Background: Psoriatic arthritis (PsA) is characterized by enthesitis. As persistent inflammation around joints results in bone and cartilage destruction and physical impairment, a detailed assessment of inflammation is essential. We previously report...

(This article belongs to the Section Personalized Therapy and Drug Delivery)
  • Article
  • Open Access
17 Citations
11,597 Views
9 Pages

13 June 2024

This study examines the impact of reminiscence therapy on cognitive and emotional well-being in institutionalized older patients with dementia. Conducted at the Long-Term Care Health Facility for the Elderly, the research involved 34 participants who...

(This article belongs to the Section Disease Biomarkers)
  • Feature Paper
  • Article
  • Open Access
2 Citations
2,695 Views
18 Pages

13 June 2024

Background: This computational analysis investigated sequence complementarities between the TRIM33 gene and human noncoding (nc)RNAs and characterized their interactions in the context of paraneoplastic dermatomyositis. Methods: TRIM33 FASTA sequence...

(This article belongs to the Section Personalized Therapy and Drug Delivery)
  • Article
  • Open Access
2 Citations
2,327 Views
11 Pages

Ultrasound Examination of Common Carotid Adventitial Thickness Can Differentiate Takayasu Arteritis and Large Vessel Giant Cell Arteritis

  • Pierluigi Macchioni,
  • Giuseppe Germanò,
  • Nicolò Girolimetto,
  • Giulia Klinowski,
  • Letizia Gavioli,
  • Francesco Muratore,
  • Alessia Laneri,
  • Caterina Ricordi,
  • Chiara Marvisi and
  • Carlo Salvarani
  • + 1 author

12 June 2024

Pathological studies have demonstrated that the adventitial layer is markedly thickened in Takayasu (TAK) as compared to large vessel giant cell arteritis (LV-GCA). An ultrasound (US) examination of the arterial vessels allows the determination of in...

(This article belongs to the Section Personalized Therapy and Drug Delivery)
  • Article
  • Open Access
2 Citations
4,096 Views
14 Pages

El Hierro Genome Study: A Genomic and Health Study in an Isolated Canary Island Population

  • Marta Puga,
  • Javier G. Serrano,
  • Elsa L. García,
  • Mario A. González Carracedo,
  • Rubén Jiménez-Canino,
  • María Pino-Yanes,
  • Robert Karlsson,
  • Patrick F. Sullivan and
  • Rosa Fregel

12 June 2024

El Hierro is the smallest and westernmost island of the Canary Islands, whose population derives from an admixture of different ancestral components and that has been subjected to genetic isolation. We established the “El Hierro Genome Study&rd...

(This article belongs to the Section Omics/Informatics)
  • Article
  • Open Access
5 Citations
3,336 Views
11 Pages

To Assess or Not to Assess: Reconsidering Day 3 Embryo Quality in Planned Freeze-All Blastocyst Cycles

  • Alessandro Bartolacci,
  • Daria Marzanati,
  • Beatrice Maria Barbagallo,
  • Lisett Solano Narduche,
  • Giulia D’Alessandro,
  • Stefania Esposito,
  • Valeria Stella Vanni,
  • Rossella Masciangelo,
  • Davide Gentilini and
  • Luca Pagliardini
  • + 1 author

11 June 2024

Day 3 embryo quality is a predictor of in vitro fertilization (IVF) success rates in cleavage-stage embryo transfer. However, the association between day 3 embryo quality and clinical outcomes in blastocyst transfer policy is largely unknown. This re...

(This article belongs to the Special Issue Current Trends and Future Challenges in Assisted Reproduction)
  • Review
  • Open Access
6 Citations
2,560 Views
12 Pages

Combined Endovascular and Endoscopic Management of a Secondary Aortoesophageal Fistula after Open Surgical Aortic Repair in a Giant Descending Thoracic Aortic Pseudoaneurysm: Case Report and Review of Literature

  • Ovidiu Stiru,
  • Reza Nayyerani,
  • Mircea Robu,
  • Roxana Carmen Geana,
  • Petru Razvan Dragulescu,
  • Oana Andreea Blibie,
  • Serban-Ion Bubenek-Turconi,
  • Vlad Anton Iliescu and
  • Catalina Parasca

11 June 2024

Secondary aortoesophageal fistula (AEF) is defined as a communication between the aorta and the esophagus, occurring after aortic disease treatment or esophageal procedures, associating very high mortality rates with treatment and being fatal without...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
3 Citations
3,711 Views
9 Pages

Dent’s Disease: A Cause of Monogenic Kidney Stones and Nephrocalcinosis

  • Lucía Diéguez,
  • Melissa Pilco,
  • Sofía Butori,
  • Andrés Kanashiro,
  • Josep Balaña,
  • Esteban Emiliani,
  • Bhaskar K. Somani and
  • Oriol Angerri

11 June 2024

Kidney stones are becoming increasingly common, affecting up to 10% of adults. A small percentage are of monogenic origin, such as Dent’s disease (DD). DD is a syndrome that causes low-molecular-weight proteinuria, hypercalciuria, nephrolithias...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Review
  • Open Access
23 Citations
6,779 Views
14 Pages

Complications of Pelvic Prolapse Surgery Using Mesh: A Systematic Review

  • Alexandru Dabica,
  • Oana Balint,
  • Flavius Olaru,
  • Cristina Secosan,
  • Ligia Balulescu,
  • Simona Brasoveanu,
  • Marilena Pirtea,
  • Diana Popin,
  • Ioana Flavia Bacila and
  • Laurentiu Pirtea

11 June 2024

Background: Pelvic organ prolapse (POP) is a public health problem that influences millions of women around the globe, and it has a significant impact on the quality of life. From the FDA statement regarding the complications of using mesh implants i...

(This article belongs to the Special Issue Interdisciplinary Approach and Personalized Therapy for Gynecological Disease)
  • Feature Paper
  • Article
  • Open Access
4 Citations
3,357 Views
12 Pages

Comparative Analysis of Frailty Scores for Predicting Adverse Outcomes in Hip Fracture Patients: Insights from the United States National Inpatient Sample

  • Maximilian Peter Forssten,
  • Yang Cao,
  • Ahmad Mohammad Ismail,
  • Lakshika Tennakoon,
  • David A. Spain and
  • Shahin Mohseni

10 June 2024

The aim of the current investigation was to compare the ability of several frailty scores to predict adverse outcomes in hip fracture patients. All adult patients (18 years or older) who suffered a hip fracture due to a fall and underwent surgical fi...

(This article belongs to the Special Issue Personalized Management in Orthopedics and Traumatology)
  • Article
  • Open Access
2,007 Views
11 Pages

Aerodynamic Study of Velopharyngeal Insufficiency in 22q11.2 Deletion Syndrome

  • Salvatore Allosso,
  • Massimo Mesolella,
  • Giovanni Motta,
  • Giuseppe Quaremba,
  • Rosaria Parrella,
  • Martina Ricciardiello and
  • Sergio Motta

10 June 2024

Objectives: We aim to verify velopharyngeal sphincter function in 22q11.2 deletion syndrome patients (22q11.2DS) to establish correlations between aerodynamic and perceptual measures of nasality, and to identify aerodynamic measures differentiating t...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
8 Citations
3,624 Views
23 Pages

Therapeutic Effects of Engineered Exosomes from RAW264.7 Cells Overexpressing hsa-let-7i-5p against Sepsis in Mice—A Comparative Study with Human Placenta-Derived Mesenchymal Stem Cell Exosomes

  • Van Long Le,
  • Chao-Yuan Chang,
  • Ching-Wei Chuang,
  • Syuan-Hao Syu,
  • Hung-Jen Shih,
  • Hong-Phuc Nguyen Vo,
  • Minh Nguyen Van and
  • Chun-Jen Huang

This study compared the therapeutic effects of engineered exosomes derived from RAW264.7 cells overexpressing hsa-let-7i-5p (engineered exosomes) to exosomes from human placenta-derived mesenchymal stem cells (hpMSC exosomes) against sepsis-induced a...

(This article belongs to the Section Personalized Medical Care)
  • Article
  • Open Access
3 Citations
3,149 Views
10 Pages

Sleep Apnea and Atrial Fibrillation: Clinical Features and Screening Diagnostic Options

  • Azamat Maratovich Baymukanov,
  • Yuliya Dmitrievna Weissman,
  • Irina Andreevna Bulavina,
  • Ilya Leonidovich Ilyich and
  • Sergey Arturovich Termosesov

Introduction: Obstructive sleep apnea (OSA) is associated with an increased risk of hypertension, coronary artery disease, heart failure (HF), and atrial fibrillation (AF). Materials and methods: A total of 179 patients aged 34–81 years were in...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
2 Citations
1,650 Views
9 Pages

Local Perineal Capillary Perforator Flaps: A Minimally Invasive Technique for the Correction of Vulvar Stenosis

  • Anna Amelia Caretto,
  • Giorgia Garganese,
  • Simona Maria Fragomeni,
  • Luca Tagliaferri,
  • Bruno Fionda,
  • Giovanni Scambia and
  • Stefano Gentileschi

Background: Vulvar stenosis is a debilitating condition that compromises sexual function, urination, and the ability to undergo gynecological examinations. The purpose of this study is to describe the technique of capillary perforator perineal flaps...

(This article belongs to the Section Sex, Gender and Hormone Based Medicine)
  • Article
  • Open Access
4 Citations
2,208 Views
10 Pages

Characteristics of Patients with Sarcoidosis with Emphasis on Acute vs. Chronic Forms—A Single Center Experience

  • Mihailo Stjepanovic,
  • Nikola Maric,
  • Slobodan Belic,
  • Jelena Milin-Lazovic,
  • Natasa Djurdjevic,
  • Jelena Jankovic,
  • Masa Petrovic,
  • Jovan Peric,
  • Ivan Tulic and
  • Violeta Mihailovic Vucinic
  • + 3 authors

Sarcoidosis is a granulomatous disease of unknown etiology that can affect almost any organ. Although the acute form can have spontaneous regression, a certain number of patients can have a chronic form, which leads to an increase in mortality and a...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
2 Citations
2,246 Views
10 Pages

The Relationship between Seropositive Rheumatoid Arthritis and Congestive Heart Failure: A Nationwide Longitudinal Cohort Study in Korea

  • Yeo Song Kim,
  • Je Beom Hong,
  • Hakyung Kim,
  • Seung Hun Sheen,
  • In-bo Han,
  • Jeong Gyun Kim,
  • Sin Soo Jeun and
  • Seil Sohn

Objectives: The aim of this nationwide longitudinal cohort study is to determine the risk of congestive heart failure (CHF) associated with a seropositive rheumatoid arthritis (RA) population in Korea. Methods: In this study, National Health Insuranc...

(This article belongs to the Section Epidemiology)
  • Article
  • Open Access
3 Citations
3,069 Views
10 Pages

Oncologic and Obstetric Outcomes Following Radical Abdominal Trachelectomy in Non-Low-Risk Early-Stage Cervical Cancers: A 10-Year Austrian Single-Center Experience

  • Melina Danisch,
  • Marlene Kranawetter,
  • Thomas Bartl,
  • Magdalena Postl,
  • Christoph Grimm,
  • Eva Langthaler and
  • Stephan Polterauer

Radical trachelectomy allows for fertility preservation in patients with early cervical cancer not qualifying as “low-risk” as defined by ConCerv. This study reports on the 10-year surgical, oncological, and obstetrical experience of pati...

(This article belongs to the Section Mechanisms of Diseases)

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J. Pers. Med. - ISSN 2075-4426