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Journal of Personalized Medicine, Volume 13, Issue 8

August 2023 - 99 articles

Cover Story: Although gBRCA status may inform breast cancer treatment decisions, not all patients who meet the guideline criteria receive gBRCA testing. To better understand real and perceived barriers, a first of its kind survey was conducted across various stakeholders (n = 430) including oncologists, surgeons, nurses, physician assistants, payers, and patients. The study found that while payers claim to cover gBRCA testing, they place controls on testing reimbursement due to the lack of proper eligibility documentation by clinicians and perceived testing overutilization. As a result, clinicians experience payer pushback, leading to reimbursement limitations, denials and hesitancy to test some patients. Encouraging all stakeholders to address this disconnect may increase testing rates for guideline-eligible patients and could lead to improved patient care. View this paper
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Articles (99)

  • Article
  • Open Access
4 Citations
2,716 Views
11 Pages

Evaluation of Intraoperative Volumetric Assessment of Breast Volume Using 3D Handheld Stereo Photogrammetric Device

  • Rafael Loucas,
  • Marios Loucas,
  • Sebastian Leitsch,
  • Katarina Danuser,
  • Gabriela Reichard,
  • Omar Haroon,
  • Julius Michael Mayer,
  • Konstantin Koban and
  • Thomas Holzbach

15 August 2023

Methods for assessing three-dimensional (3D) breast volume are becoming increasingly popular in breast surgery. However, the precision of intraoperative volumetric assessment is still unclear. Until now, only non-validated scanning systems have been...

  • Review
  • Open Access
5 Citations
2,960 Views
14 Pages

Modulation of Radiation Doses and Chimeric Antigen Receptor T Cells: A Promising New Weapon in Solid Tumors—A Narrative Review

  • Antonio Pontoriero,
  • Paola Critelli,
  • Federico Chillari,
  • Giacomo Ferrantelli,
  • Miriam Sciacca,
  • Anna Brogna,
  • Silvana Parisi and
  • Stefano Pergolizzi

14 August 2023

Tumor behavior is determined by its interaction with the tumor microenvironment (TME). Chimeric antigen receptor (CART) cell therapy represents a new form of cellular immunotherapy (IT). Immune cells present a different sensitivity to radiation thera...

  • Article
  • Open Access
5 Citations
6,651 Views
12 Pages

Mismatch Repair Protein Expression in Endometrial Cancer: Assessing Concordance and Unveiling Pitfalls in Two Different Immunohistochemistry Assays

  • Hiroshi Yoshida,
  • Waku Takigawa,
  • Mayumi Kobayashi-Kato,
  • Tadaaki Nishikawa,
  • Kouya Shiraishi and
  • Mitsuya Ishikawa

14 August 2023

This study aimed to compare the concordance and interchangeability of the Dako/Agilent and Ventana/Roche mismatch repair (MMR) immunohistochemistry (IHC) assays commonly used in pathology. It also aimed to provide diagnostic insights by examining the...

  • Review
  • Open Access
11 Citations
5,192 Views
18 Pages

The Role of Osteopontin in Respiratory Health and Disease

  • Georgios I. Barkas and
  • Ourania S. Kotsiou

14 August 2023

The biological functions of osteopontin (OPN) are diverse and specific to physiological and pathophysiological conditions implicated in inflammation, biomineralization, cardiovascular diseases, cellular viability, cancer, diabetes, and renal stone di...

  • Article
  • Open Access
6 Citations
2,457 Views
14 Pages

The CBCT Retrospective Study on Underwood Septa and Their Related Factors in Maxillary Sinuses—A Proposal of Classification

  • Kamil Nelke,
  • Dorota Diakowska,
  • Monika Morawska-Kochman,
  • Maciej Janeczek,
  • Edyta Pasicka,
  • Marceli Łukaszewski,
  • Krzysztof Żak,
  • Jan Nienartowicz and
  • Maciej Dobrzyński

14 August 2023

Introduction. The presence of bone septum in the maxillary sinus is one of the most common anatomical findings. So-called Underwood septa (US) are an atypical bone formation in the maxillary sinuses. Mostly they are quite easily found in CBCT studies...

  • Article
  • Open Access
6 Citations
1,782 Views
11 Pages

14 August 2023

Background: Recent studies have been able to show certain benefits of Customized, Individually Made (CIM) compared to Off-the-Shelf (OTS) total knee arthroplasties (TKAs), but evidence is still lacking regarding the benefits of these implant systems....

  • Article
  • Open Access
4 Citations
3,681 Views
9 Pages

14 August 2023

Orthognathic surgery is used to modify anomalies in maxillomandibular position; this process can significantly affect the anatomy of the airway and cause functional changes. This study aims to define the impact of mandibular maxillary movement on the...

  • Review
  • Open Access
39 Citations
5,693 Views
15 Pages

13 August 2023

Intelligent digital twins closely resemble their real-life counterparts. In health and medical care, they enable the real-time monitoring of patients, whereby large amounts of data can be collected to produce actionable information. These powerful to...

  • Article
  • Open Access
3 Citations
2,073 Views
11 Pages

Gastrointestinal Stromal Tumors: Our Ten-Year Experience of a Single-Center Tertiary Hospital

  • Georgios Tzikos,
  • Alexandra-Eleftheria Menni,
  • Despoina Krokou,
  • Angeliki Vouchara,
  • Soultana Doutsini,
  • Eleni Karlafti,
  • Anestis Karakatsanis,
  • Aristeidis Ioannidis,
  • Stavros Panidis and
  • Theodosios Papavramidis
  • + 2 authors

13 August 2023

Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. They have variable clinical presentation, prognosis, and molecular characteristics. Here, we present the results of our ret...

  • Review
  • Open Access
11 Citations
6,997 Views
22 Pages

Unlocking the Potential of Mesenchymal Stem Cells in Gynecology: Where Are We Now?

  • Ivana Erceg Ivkošić,
  • Rajko Fureš,
  • Vesna Ćosić,
  • Nika Mikelin,
  • Luka Bulić,
  • Domagoj Dobranić,
  • Petar Brlek and
  • Dragan Primorac

13 August 2023

Stem cells, with their remarkable capacity for differentiation into diverse cell types, are vital for the development as well as maintenance of health and homeostasis. Two unique abilities set them apart from other cells: self-renewal and the capacit...

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J. Pers. Med. - ISSN 2075-4426