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Journal of Personalized Medicine, Volume 13, Issue 8

August 2023 - 99 articles

Cover Story: Although gBRCA status may inform breast cancer treatment decisions, not all patients who meet the guideline criteria receive gBRCA testing. To better understand real and perceived barriers, a first of its kind survey was conducted across various stakeholders (n = 430) including oncologists, surgeons, nurses, physician assistants, payers, and patients. The study found that while payers claim to cover gBRCA testing, they place controls on testing reimbursement due to the lack of proper eligibility documentation by clinicians and perceived testing overutilization. As a result, clinicians experience payer pushback, leading to reimbursement limitations, denials and hesitancy to test some patients. Encouraging all stakeholders to address this disconnect may increase testing rates for guideline-eligible patients and could lead to improved patient care. View this paper
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Articles (99)

  • Article
  • Open Access
3 Citations
6,083 Views
15 Pages

Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients

  • Maria del Mar Ras-Jiménez,
  • Raúl Ramos-Polo,
  • Josep Francesch Manzano,
  • Miriam Corbella Santano,
  • Herminio Morillas Climent,
  • Núria Jose-Bazán,
  • Santiago Jiménez-Marrero,
  • Paloma Garcimartin Cerezo,
  • Sergi Yun Viladomat and
  • Pedro Moliner Borja
  • + 10 authors

21 August 2023

The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF)...

  • Review
  • Open Access
3 Citations
2,982 Views
40 Pages

Progress in Research on Stem Cells in Neonatal Refractory Diseases

  • Fangjun Huang,
  • Yang He,
  • Meng Zhang,
  • Keren Luo,
  • Jiawen Li,
  • Jiali Li,
  • Xinyu Zhang,
  • Xiaoyan Dong and
  • Jun Tang

21 August 2023

With the development and progress of medical technology, the survival rate of premature and low-birth-weight infants has increased, as has the incidence of a variety of neonatal diseases, such as hypoxic–ischemic encephalopathy, intraventricula...

  • Article
  • Open Access
5 Citations
2,418 Views
19 Pages

An Innovative Scoring System to Select the Optimal Surgery in Breast Cancer after Neoadjuvant Chemotherapy

  • Antonio Franco,
  • Alba Di Leone,
  • Marco Conti,
  • Alessandra Fabi,
  • Luisa Carbognin,
  • Andreina Daniela Terribile,
  • Paolo Belli,
  • Armando Orlandi,
  • Martin Alejandro Sanchez and
  • Francesca Moschella
  • + 13 authors

21 August 2023

Introduction: The selection of surgery post-neoadjuvant chemotherapy (NACT) is difficult and based on surgeons’ expertise. The aim of this study was to create a post-NEoadjuvant Score System (pNESSy) to choose surgery, optimizing oncological an...

  • Article
  • Open Access
7 Citations
2,206 Views
13 Pages

Preoperative Lower-Limb Muscle Predictors for Gait Speed Improvement after Total Hip Arthroplasty for Patients with Osteoarthritis

  • Tadashi Yasuda,
  • Satoshi Ota,
  • Sadaki Mitsuzawa,
  • Shinnosuke Yamashita,
  • Yoshihiro Tsukamoto,
  • Hisataka Takeuchi and
  • Eijiro Onishi

20 August 2023

This study aimed to identify preoperative lower-limb muscle predictors for gait speed improvement after total hip arthroplasty (THA) with hip osteoarthritis. Gait speed improvement was evaluated as the subtraction of preoperative speed from postopera...

  • Article
  • Open Access
3 Citations
2,773 Views
14 Pages

Cortical–Subcortical Functional Preservation and Rehabilitation in Neuro-Oncology: Tractography-MIPS-IONM-TMS Proof-of-Concept Study

  • Francesca Vitulli,
  • Dimitrios Kalaitzoglou,
  • Christos Soumpasis,
  • Alba Díaz-Baamonde,
  • José David Siado Mosquera,
  • Richard Gullan,
  • Francesco Vergani,
  • Keyoumars Ashkan,
  • Ranjeev Bhangoo and
  • Ana Mirallave-Pescador
  • + 1 author

20 August 2023

Surgical management of deep-seated brain tumors requires precise functional navigation and minimally invasive surgery. Preoperative mapping using navigated transcranial magnetic stimulation (nTMS), intraoperative neurophysiological monitoring (IONM),...

  • Article
  • Open Access
1 Citations
1,982 Views
12 Pages

Attenuated Total Reflection Fourier-Transform Infrared Spectral Discrimination in Human Tissue of Oesophageal Transformation to Adenocarcinoma

  • Ishaan Maitra,
  • Camilo L. M. Morais,
  • Kássio M. G. Lima,
  • Katherine M. Ashton,
  • Danielle Bury,
  • Ravindra S. Date and
  • Francis L. Martin

20 August 2023

This study presents ATR-FTIR (attenuated total reflectance Fourier-transform infrared) spectral analysis of ex vivo oesophageal tissue including all classifications to oesophageal adenocarcinoma (OAC). The article adds further validation to previous...

  • Article
  • Open Access
5 Citations
2,360 Views
10 Pages

Evaluation of the Performance of OTOPLAN-Based Cochlear Implant Electrode Array Selection: A Retrospective Study

  • Dayse Távora-Vieira,
  • Marcus Voola,
  • Jafri Kuthubutheen,
  • Peter Friedland,
  • Daren Gibson and
  • Aanand Acharya

20 August 2023

Otoplan is a surgical planning software designed to assist with cochlear implant surgery. One of its outputs is a recommendation of electrode array type based on imaging parameters. In this retrospective study, we evaluated the differences in auditor...

  • Article
  • Open Access
5 Citations
4,632 Views
9 Pages

19 August 2023

A Personal Health Record (PHR) is a patient-managed platform for health data. Most hospitals provide a PHR as an extension of the Electronic Medical Record (EMR). However, there are unresolved issues around the adoption rate, functionalities, barrier...

  • Article
  • Open Access
6 Citations
9,161 Views
15 Pages

19 August 2023

Hashimoto thyroiditis (HT) is a thyroid-specific autoimmune disorder, triggering hypothyroidism in a population with an adequate dietary intake. Despite the current conventional treatment focuses on the permanent replacement of levothyroxine (LT4) de...

  • Article
  • Open Access
1 Citations
2,137 Views
14 Pages

Characteristics of Kidney Transplant Recipients with Prolonged Pre-Transplant Dialysis Duration as Identified by Machine Learning Consensus Clustering: Pathway to Personalized Care

  • Charat Thongprayoon,
  • Supawit Tangpanithandee,
  • Caroline C. Jadlowiec,
  • Shennen A. Mao,
  • Michael A. Mao,
  • Pradeep Vaitla,
  • Prakrati C. Acharya,
  • Napat Leeaphorn,
  • Wisit Kaewput and
  • Pattharawin Pattharanitima
  • + 6 authors

19 August 2023

Longer pre-transplant dialysis duration is known to be associated with worse post-transplant outcomes. Our study aimed to cluster kidney transplant recipients with prolonged dialysis duration before transplant using an unsupervised machine learning a...

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J. Pers. Med. - ISSN 2075-4426