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Journal of Personalized Medicine, Volume 12, Issue 2

February 2022 - 202 articles

Cover Story: Older people are more susceptible to anticholinergic effects on the central nervous system. In this paper, we develop a new scale (CALS) that includes 217 different drugs with anticholinergic properties. We observed an association between cognitive impairment and the anticholinergic burden when measured by CALS, but not when the ACB scale was applied. CALS can help to raise awareness among clinicians of the problems associated with the use of medications with anticholinergic effects and promote a better personalized pharmacological approach for each patient. View this paper
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Articles (202)

  • Article
  • Open Access
23 Citations
3,671 Views
11 Pages

miR-155: A Potential Biomarker for Predicting Mortality in COVID-19 Patients

  • Reut Kassif-Lerner,
  • Keren Zloto,
  • Nadav Rubin,
  • Keren Asraf,
  • Ram Doolman,
  • Gidi Paret and
  • Yael Nevo-Caspi

21 February 2022

COVID-19, a pandemic of severe acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2), continues to pose diagnostic and therapeutic challenges due to its unpredictable clinical course. Prognostic biomarkers may improve care by enabling quick...

  • Review
  • Open Access
13 Citations
4,301 Views
16 Pages

21 February 2022

Sleep disturbances are more common in patients with Parkinson’s disease (PD) than in the general population and are considered one of the most troublesome symptoms by these patients. Insomnia represents one of the most common sleep disturbances...

  • Review
  • Open Access
30 Citations
6,597 Views
13 Pages

21 February 2022

Background: Platinum-based agents may benefit patients with triple-negative breast cancer (TNBC) whose tumors are dysfunctional in DNA repair mechanisms associated with the homologous recombination repair (HRR) genes. The purpose of this meta-analysi...

  • Perspective
  • Open Access
26 Citations
12,342 Views
18 Pages

Reward Deficiency Syndrome (RDS) Surprisingly Is Evolutionary and Found Everywhere: Is It “Blowin’ in the Wind”?

  • Kenneth Blum,
  • Thomas McLaughlin,
  • Abdalla Bowirrat,
  • Edward J. Modestino,
  • David Baron,
  • Luis Llanos Gomez,
  • Mauro Ceccanti,
  • Eric R. Braverman,
  • Panayotis K. Thanos and
  • Jean Lud Cadet
  • + 7 authors

21 February 2022

Reward Deficiency Syndrome (RDS) encompasses many mental health disorders, including a wide range of addictions and compulsive and impulsive behaviors. Described as an octopus of behavioral dysfunction, RDS refers to abnormal behavior caused by a bre...

  • Article
  • Open Access
9 Citations
3,628 Views
17 Pages

Cerebral Protection in TAVR—Can We Do Without? A Real-World All-Comer Intention-to-Treat Study—Impact on Stroke Rate, Length of Hospital Stay, and Twelve-Month Mortality

  • Carolina Donà,
  • Matthias Koschutnik,
  • Christian Nitsche,
  • Max-Paul Winter,
  • Veronika Seidl,
  • Jolanta Siller-Matula,
  • Markus Mach,
  • Martin Andreas,
  • Philipp Bartko and
  • Andreas Anselm Kammerlander
  • + 4 authors

21 February 2022

Background: Stroke associated with transcatheter aortic valve replacement (TAVR) is a potentially devastating complication. Until recently, the Sentinel™ Cerebral Protection System (CPS; Boston Scientific, Marlborough, MA, USA) has been the onl...

  • Article
  • Open Access
2 Citations
2,767 Views
11 Pages

Analysis of the Efficacy of Universal Screening of Coronavirus Disease with Antigen-Detecting Rapid Diagnostic Tests at Point-or-Care Settings and Sharing the Experience of Admission Protocol—A Pilot Study

  • Ji Young Park,
  • Joo Hee Lee,
  • Bong Ki Cha,
  • Boo-Seop Kim,
  • Han-Jun Lee,
  • Gi Hyeon Kim,
  • Kyu-Tae Kang,
  • Yong-Soon Lee,
  • Seok Keun Ahn and
  • Seong Hwan Kim

20 February 2022

Aims: To introduce the admission protocol of a COVID-19 specialized hospital outlined by the government, including the assessment of reverse transcription polymerase chain reaction (RT-PCR), low dose chest computed tomography (CT) and antigen-detecti...

  • Article
  • Open Access
6 Citations
4,428 Views
17 Pages

20 February 2022

Vitamin D plays an essential role in cognitive functions as well as regulating calcium homeostasis and the immune system. Many epidemiological studies have also shown the close relationship between vitamin D deficiency (VDD) and the risk of schizophr...

  • Article
  • Open Access
25 Citations
3,281 Views
10 Pages

20 February 2022

Diabetic retinopathy (DR) is one of the most important microvascular complications associated with diabetes mellitus. The early signs of DR are microaneurysms, which can lead to complete vision loss. The detection of DR at an early stage can help to...

  • Article
  • Open Access
7 Citations
4,814 Views
13 Pages

Pharmacogenomics-Guided Pharmacotherapy in Patients with Major Depressive Disorder or Bipolar Disorder Affected by Treatment-Resistant Depressive Episodes: A Long-Term Follow-Up Study

  • Antonio Del Casale,
  • Leda Marina Pomes,
  • Luca Bonanni,
  • Federica Fiaschè,
  • Clarissa Zocchi,
  • Alessio Padovano,
  • Ottavia De Luca,
  • Gloria Angeletti,
  • Roberto Brugnoli and
  • Paolo Girardi
  • + 5 authors

19 February 2022

Treatment-resistant depression (TRD) reduces affected patients’ quality of life and leads to important social health care costs. Pharmacogenomics-guided treatment (PGT) may be effective in the cure of TRD. The main aim of this study was to eval...

  • Article
  • Open Access
9 Citations
4,811 Views
14 Pages

Understanding the Risks and Benefits of a Patient Portal Configured for HIV Care: Patient and Healthcare Professional Perspectives

  • Dominic Chu,
  • David Lessard,
  • Moustafa A. Laymouna,
  • Kim Engler,
  • Tibor Schuster,
  • Yuanchao Ma,
  • Nadine Kronfli,
  • Jean-Pierre Routy,
  • Tarek Hijal and
  • Karine Lacombe
  • + 3 authors

19 February 2022

Background: Like other chronic viral illnesses, HIV infection necessitates consistent self-management and adherence to care and treatment, which in turn relies on optimal collaboration between patients and healthcare professionals (HCPs), including p...

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J. Pers. Med. - ISSN 2075-4426