Next Article in Journal
Integrated Proteomics Based on 2D Gel Electrophoresis and Mass Spectrometry with Validations: Identification of a Biomarker Compendium for Oral Submucous Fibrosis—An Indian Study
Previous Article in Journal
A Novel Integrated Biomarker for Evaluation of Risk and Severity of Coronary Atherosclerosis, and Its Validation
Article

CRIDECO Anticholinergic Load Scale: An Updated Anticholinergic Burden Scale. Comparison with the ACB Scale in Spanish Individuals with Subjective Memory Complaints

1
Cátedra DeCo MICOF-CEU UCH, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain
2
Department of Pharmacy, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain
3
Institut de Biomedicina de València-CSIC, CIBERNED, Unitat Mixta de Neurologia i Genetica, IIS La Fe, 46010 Valencia, Spain
4
Alzheimer Disease Research Group, Health Research Institute La Fe, 46026 Valencia, Spain
5
Embedded Systems and Artificial Intelligence Group, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Marco Costanzi
J. Pers. Med. 2022, 12(2), 207; https://doi.org/10.3390/jpm12020207
Received: 4 January 2022 / Revised: 30 January 2022 / Accepted: 31 January 2022 / Published: 3 February 2022
(This article belongs to the Section Methodology, Drug and Device Discovery)
The increase in life expectancy has also been accompanied by an increase in the use of medication to treat chronic diseases. Polypharmacy is associated with medication-related problems such as the increase in the anticholinergic burden. Older people are more susceptible to anticholinergic effects on the central nervous system and this, in turn, may be related to cognitive impairment. In this paper, we develop an updated anticholinergic burden scale, the CRIDECO Anticholinergic Load Scale (CALS) via a systematic review of the literature and compare it with the currently most used Anticholinergic Burden Scale (ACB). Our new scale includes 217 different drugs with anticholinergic properties, 129 more than the ACB. Given the effect that anticholinergic medications have on cognitive performance, we then used both scales to investigate the relationship between anticholinergic burden and cognitive impairment in adult Spanish subjects with subjective memory complaint. In our population, we observed an association between cognitive impairment and the anticholinergic burden when measured by the new CALS, but not when the ACB was applied. The use of a more comprehensive and upgraded scale will allow better discrimination of the risk associated with the use of anticholinergic medications on cognitive impairment. CALS can help raise awareness among clinicians of the problems associated with the use of medications, or combinations of them, with large anticholinergic effect, and promote a better personalized pharmacological approach for each patient. View Full-Text
Keywords: cognitive impairment; anticholinergic burden scale; anticholinergic drug; subjective memory complaint cognitive impairment; anticholinergic burden scale; anticholinergic drug; subjective memory complaint
Show Figures

Figure 1

MDPI and ACS Style

Ramos, H.; Moreno, L.; Pérez-Tur, J.; Cháfer-Pericás, C.; García-Lluch, G.; Pardo, J. CRIDECO Anticholinergic Load Scale: An Updated Anticholinergic Burden Scale. Comparison with the ACB Scale in Spanish Individuals with Subjective Memory Complaints. J. Pers. Med. 2022, 12, 207. https://doi.org/10.3390/jpm12020207

AMA Style

Ramos H, Moreno L, Pérez-Tur J, Cháfer-Pericás C, García-Lluch G, Pardo J. CRIDECO Anticholinergic Load Scale: An Updated Anticholinergic Burden Scale. Comparison with the ACB Scale in Spanish Individuals with Subjective Memory Complaints. Journal of Personalized Medicine. 2022; 12(2):207. https://doi.org/10.3390/jpm12020207

Chicago/Turabian Style

Ramos, Hernán, Lucrecia Moreno, Jordi Pérez-Tur, Consuelo Cháfer-Pericás, Gemma García-Lluch, and Juan Pardo. 2022. "CRIDECO Anticholinergic Load Scale: An Updated Anticholinergic Burden Scale. Comparison with the ACB Scale in Spanish Individuals with Subjective Memory Complaints" Journal of Personalized Medicine 12, no. 2: 207. https://doi.org/10.3390/jpm12020207

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop