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Diagnostics, Volume 12, Issue 1

January 2022 - 226 articles

Cover Story: Immune checkpoint inhibitors are monoclonal antibodies which unmask cancer to the immune system by blocking negative feedback signalling in T cells. These drugs have revolutionised cancer care and prolonged survival and increased cure rates in many malignancies. However, they are expensive, cause autoimmune toxicity and help only 40% of patients who receive them. The Healey Bird et al. review licensed tissue biomarkers of response and their limitations as well as emerging tissue, blood, and stool biomarkers which may help to predict both response and toxicity as a new generation of immune checkpoint inhibitors becomes available in cancer care. View this paper.
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Articles (226)

  • Case Report
  • Open Access
8 Citations
6,496 Views
19 Pages

How Many Times Can One Go Back to the Drawing Board before the Accurate Diagnosis and Surgical Treatment of Glucagonoma?

  • Carmen Sorina Martin,
  • Ovidiu Dumitru Parfeni,
  • Liliana Gabriela Popa,
  • Mara Madalina Mihai,
  • Dana Terzea,
  • Vlad Herlea,
  • Mirela Gherghe,
  • Razvan Adam,
  • Osama Alnuaimi and
  • Valentin Calu
  • + 4 authors

Glucagonomas are neuroendocrine tumors (NETs) that arise from the alpha cells of the pancreatic islets. They are typically slow-growing tumors associated with abnormal glucagon secretion, resulting in one or more non-specific clinical features, such...

  • Review
  • Open Access
20 Citations
3,851 Views
14 Pages

Introduction: Vertical artifacts, including B lines, are frequently seen in a variety of lung diseases. Their sonomorphology varies in length, width, shape, and internal reverberations. The reason for this diversity is still unknown and is the cause...

  • Systematic Review
  • Open Access
14 Citations
6,593 Views
17 Pages

Microbial Translocation and Perinatal Asphyxia/Hypoxia: A Systematic Review

  • Dimitra-Ifigeneia Matara,
  • Abraham Pouliakis,
  • Theodoros Xanthos,
  • Rozeta Sokou,
  • Georgios Kafalidis,
  • Zoi Iliodromiti,
  • Theodora Boutsikou,
  • Nicoletta Iacovidou and
  • Christos Salakos

The microbiome is vital for the proper function of the gastrointestinal tract (GIT) and the maintenance of overall wellbeing. Gut ischemia may lead to disruption of the intestinal mucosal barrier, resulting in bacterial translocation. In this systema...

  • Article
  • Open Access
14 Citations
2,870 Views
11 Pages

Resistome and Virulome of Multi-Drug Resistant E. coli ST131 Isolated from Residents of Long-Term Care Facilities in the Northern Italian Region

  • Sabrina Cherubini,
  • Mariagrazia Perilli,
  • Anna Maria Azzini,
  • Evelina Tacconelli,
  • Laura Maccacaro,
  • Alda Bazaj,
  • Laura Naso,
  • Gianfranco Amicosante,
  • LTCF-Veneto Working Group and
  • Giuliana Lo Cascio
  • + 1 author

Long-term care facilities (LTCFs) are important reservoirs of antimicrobial-resistant (AMR) bacteria which colonize patients transferred from the hospital, or they may emerge in the facility as a result of mutation or gene transfer. In the present st...

  • Article
  • Open Access
34 Citations
4,848 Views
19 Pages

Background: Insulin resistance is a common etiology of metabolic syndrome, but receiver operating characteristic (ROC) curve analysis shows a weak association in Koreans. Using a machine learning (ML) approach, we aimed to generate the best model for...

  • Article
  • Open Access
8 Citations
3,114 Views
10 Pages

Impact of Antibiotic Prophylaxis on Infection Rate after Endoscopic Ultrasound Through-the-Needle Biopsy of Pancreatic Cysts: A Propensity Score-Matched Study

  • Antonio Facciorusso,
  • Martha Arevalo-Mora,
  • Maria Cristina Conti Bellocchi,
  • Laura Bernardoni,
  • Daryl Ramai,
  • Paraskevas Gkolfakis,
  • Domenico Loizzi,
  • Nicola Muscatiello,
  • Antonio Ambrosi and
  • Nicola Tartaglia
  • + 4 authors

Background: Despite weak evidence, antibiotic prophylaxis prior to endoscopic ultrasound-guided through-the-needle biopsy (EUS-TTNB) of pancreatic cystic lesions (PCLs) is routinely used in clinical practice. We aim to compare a group of patients tre...

  • Case Report
  • Open Access
5 Citations
3,500 Views
9 Pages

Isolated Splenic Metastasis of Primary Lung Cancer Presented as Metachronous Oligometastatic Disease—A Case Report

  • Milorad Reljic,
  • Boris Tadic,
  • Katarina Stosic,
  • Milica Mitrovic,
  • Nikola Grubor,
  • Stefan Kmezic,
  • Miljan Ceranic and
  • Vladimir Milosavljevic

Modern oncology practice and new antitumor drugs prolonged disease-free intervals in patients with lung cancer. Patients with distant metastatic disease are treated only with palliative intent. The International Association for the Study of Lung Canc...

  • Article
  • Open Access
10 Citations
3,572 Views
11 Pages

Recent evidence suggests that a cytology–histology correlation (CHC) with discrepancy detection can both evaluate errors and improve the sensitivity and specificity of the cytologic method. We aimed to analyze the errors in cytologic–hist...

  • Review
  • Open Access
37 Citations
11,466 Views
33 Pages

Staphylococcus aureus is an opportunistic pathogen responsible for a wide range of infections in humans, such as skin and soft tissue infections, pneumonia, food poisoning or sepsis. Historically, S. aureus was able to rapidly adapt to anti-staphyloc...

  • Case Report
  • Open Access
8 Citations
2,793 Views
8 Pages

Identification of the First Single GSDME Exon 8 Structural Variants Associated with Autosomal Dominant Hearing Loss

  • Luke Mansard,
  • Christel Vaché,
  • Julie Bianchi,
  • Corinne Baudoin,
  • Isabelle Perthus,
  • Bertrand Isidor,
  • Catherine Blanchet,
  • David Baux,
  • Michel Koenig and
  • Vasiliki Kalatzis
  • + 1 author

GSDME, also known as DFNA5, is a gene implicated in autosomal dominant nonsyndromic hearing loss (ADNSHL), affecting, at first, the high frequencies with a subsequent progression over all frequencies. To date, all the GSDME pathogenic variants associ...

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Diagnostics - ISSN 2075-4418