Diagnosis and Treatment of Erectile Dysfunction

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 492

Special Issue Editor


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Guest Editor
1. Microsurgical Potency Reconstruction and Research Center, Puli Christian Hospital, Puli 54546, Taiwan
2. Division of Cardiovascular Medicine, Microsurgery Potency Reconstruction and Research Center, Yuan Rung Hospital, Yuanlin, Changhua 51052, Taiwan
Interests: anatomy and physiology of the human penis; erection-related physiology; penile disorders; penile tunica albuginea; penile fibro-vascular assembly; varied male potency reconstruction and restoration strategies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Before 1519, Sage Da Vinci illustrated conventional penile fibro-vascular anatomy (CPFA); it depicts a well-illustrated fibro-vascular model commonly agreed upon as a single tunica albuginea (TA) surrounding the corpora cavernosa (CC) and one deep dorsal vein flanked by a pair of dorsal arteries between the TA and Buck's fascia. This version has prevailed in the medical literature and has been used to derive contemporary therapeutic strategies for erectile dysfunction (ED). Recently, a de novo penile fibro-vascular assembly (DNPFA) was ascertained, with which a bi-layered TA, one DDV, two cavernosal veins, and four par-arterial veins, were found. As medical treatment strategy must be rooted in anatomy and physiology, given that CPFA needs to be updated and sustainable, one may question whether relevant derived therapeutic strategies also need to be updated. Every professional enjoys advanced technology, particularly medical diagnosis and treatment strategies. We seek to invite authors who diagnose and treat ED and share their expertise on this issue. The topics include, but are not limited to, the following:

  1. Varied non-invasive methods in diagnosing ED, such as rigid scanning, sonography, CT, and MRI imaging.
  2. Varied invasive methods in identifying and classifying ED, such as prostaglandin E 1 test, cavernosography, arteriography, etc.
  3. Medical treatment of ED, including phosphor-di-esterase-5 inhibitor with varied preparations.
  4. Endo-vascular intervention for erection restoration, including erection-related venous contributor and arterial factor.
  5. Surgical strategies for restoring or enhancing erection quality, either physiologically or artificially.
  6. Miscellaneous methods for diagnosing and treating ED scientifically, including alternative medicine.

Dr. Geng-Long Hsu
Guest Editor

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Keywords

  • erectile dysfunction
  • non-invasive methods
  • surgical strategies

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Published Papers (1 paper)

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Research

17 pages, 487 KiB  
Article
Comparative Effects of Tadalafil Cream Versus Oral Tadalafil on Males with Erectile Disfunction Regarding Relationship Dynamics: A Secondary Analysis of Dyadic Adjustment Outcomes in a Randomized Crossover Trial
by Dragoș-Mihail Trifu, Daniel-Corneliu Leucuța, Martina-Luciana Pintea-Trifu, Florin Elec, Nicolae Crișan, Dan Eniu and Ioan Coman
Life 2025, 15(4), 668; https://doi.org/10.3390/life15040668 - 17 Apr 2025
Viewed by 367
Abstract
Background/Objectives: Relationship quality is closely tied to sexual health. This study compared the effects of tadalafil cream and oral tadalafil on Dyadic Adjustment Scale (DAS) subscales and assessed the influence of age on treatment outcomes. Methods: This study includes a secondary analysis of [...] Read more.
Background/Objectives: Relationship quality is closely tied to sexual health. This study compared the effects of tadalafil cream and oral tadalafil on Dyadic Adjustment Scale (DAS) subscales and assessed the influence of age on treatment outcomes. Methods: This study includes a secondary analysis of data collected during a previously published randomized controlled crossover trial, but they were not published at that time. The participants (n = 35) completed both tadalafil cream and oral tadalafil interventions in a crossover design. Dyadic Adjustment, including DAS subscales, was assessed at baseline and after each intervention. Improvements across all DAS subscales were greater in the tadalafil cream group compared to the oral tadalafil group. Statistically significant differences were observed for Affective Expression (5.45, 95% CI: 0.22–10.67, p = 0.041) in the multivariate model. Notable gains were observed in Affective Expression and Dyadic Cohesion for the cream route. Within-group analysis showed statistically significant improvements in Affective Expression for both treatments and in Dyadic Cohesion for the cream route. The results show that younger participants benefited more from treatment, particularly in Affective Expression, Consensus subscales, and overall for Dyadic Adjustment. Conclusion: This study provides evidence that tadalafil intervention had a favorable impact on relationship dynamics, particularly in Affective Expression and Dyadic Cohesion. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Erectile Dysfunction)
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