You are currently viewing a new version of our website. To view the old version click .

Life, Volume 12, Issue 1

January 2022 - 133 articles

Cover Story: It has been proposed that viroids are direct descendants of primordial RNA replicons that are present in the hypothetical RNA world. We argue, however, that a much later origin of viroids, possibly from recently discovered mobile genetic elements known as retrozymes, is a far more plausible evolutionary scenario. Nevertheless, viroids and viroid-like circular RNAs are minimal replicators that are likely to be close to the theoretical lower limit of replicator size and arguably comprise the paradigm for replicator emergence. Thus, although viroid-like replicators are unlikely to be direct descendants of primordial RNA replicators, the study of the diversity and evolution of these ultimate genetic parasites can yield insights into the earliest stages of evolution. View this paper.
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (133)

  • Article
  • Open Access
3 Citations
4,217 Views
25 Pages

SAXS Reveals the Stabilization Effects of Modified Sugars on Model Proteins

  • Astra Piccinini,
  • Eva C. Lourenço,
  • Osvaldo S. Ascenso,
  • Maria Rita Ventura,
  • Heinz Amenitsch,
  • Paolo Moretti,
  • Paolo Mariani,
  • Maria Grazia Ortore and
  • Francesco Spinozzi

15 January 2022

Many proteins are usually not stable under different stresses, such as temperature and pH variations, mechanical stresses, high concentrations, and high saline contents, and their transport is always difficult, because they need to be maintained in a...

  • Communication
  • Open Access
3 Citations
2,846 Views
7 Pages

Telemedicine as a Means to an End, Not an End in Itself

  • Michele Vitacca and
  • Simonetta Scalvini

15 January 2022

Telemedicine (TM)—the management of disease at a distance—has potential usefulness for patients with advanced respiratory disease. Underscoring this potential is the dramatic expansion of its applications in clinical medicine. However, si...

  • Article
  • Open Access
2 Citations
2,767 Views
10 Pages

High-Throughput Sequencing Haplotype Analysis Indicates in LRRK2 Gene a Potential Risk Factor for Endemic Parkinsonism in Southeastern Moravia, Czech Republic

  • Kristyna Kolarikova,
  • Radek Vodicka,
  • Radek Vrtel,
  • Julia Stellmachova,
  • Martin Prochazka,
  • Katerina Mensikova,
  • Tereza Bartonikova,
  • Tomas Furst,
  • Petr Kanovsky and
  • Jan Geryk

14 January 2022

Parkinson’s disease and parkinsonism are relatively common neurodegenerative disorders. This study aimed to assess potential genetic risk factors of haplotypes in genes associated with parkinsonism in a population in which endemic parkinsonism...

  • Article
  • Open Access
8 Citations
3,250 Views
11 Pages

14 January 2022

(1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was a...

  • Article
  • Open Access
9 Citations
2,750 Views
12 Pages

Sleep Apnea Detection Based on Multi-Scale Residual Network

  • Hengyang Fang,
  • Changhua Lu,
  • Feng Hong,
  • Weiwei Jiang and
  • Tao Wang

14 January 2022

Aiming at the fact that traditional convolutional neural networks cannot effectively extract signal features in complex application scenarios, a sleep apnea (SA) detection method based on multi-scale residual networks is proposed. First, we analyze t...

  • Review
  • Open Access
14 Citations
8,616 Views
18 Pages

Neurological Complications of Biological Treatment of Psoriasis

  • Mateusz Kamil Ożóg,
  • Beniamin Oskar Grabarek,
  • Magdalena Wierzbik-Strońska and
  • Magdalena Świder

14 January 2022

In the available literature, little attention has been paid to the assessment of psoriasis and the biological therapy used for it and the nervous system. The purpose of this article is to discuss the relationship between psoriasis and the nervous sys...

  • Review
  • Open Access
17 Citations
8,148 Views
13 Pages

Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review

  • José María Llamas-Molina,
  • Alejandro Carrero-Castaño,
  • Ricardo Ruiz-Villaverde and
  • Antonio Campos

14 January 2022

Androgenetic alopecia (AGA) is an androgen-dependent process and represents the most frequent non-scarring alopecia. Treatments for AGA do not always achieve a satisfactory result for the patient, and sometimes cause side effects that lead to discont...

  • Article
  • Open Access
7 Citations
3,090 Views
25 Pages

13 January 2022

Understanding non-covalent biomolecular recognition, which includes drug–protein bound states and their binding/unbinding processes, is of fundamental importance in chemistry, biology, and medicine. Fully revealing the factors that govern the b...

  • Article
  • Open Access
11 Citations
4,204 Views
21 Pages

13 January 2022

The biological impacts of the Fukushima nuclear accident, in 2011, on wildlife have been studied in many organisms, including the pale grass blue butterfly and its host plant, the creeping wood sorrel Oxalis corniculata. Here, we performed an LC&ndas...

  • Article
  • Open Access
11 Citations
3,221 Views
16 Pages

13 January 2022

Furanodienone (FDN), a major bioactive component of sesquiterpenes produced from Rhizoma Curcumae, has been repeatedly acknowledged for its intrinsic anticancer efficacy against different types of cancer. In this study, we aimed to investigate the cy...

of 14

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Life - ISSN 2075-1729