Next Article in Journal
Arsenolipids in Cultured Picocystis Strain ML and Their Occurrence in Biota and Sediment from Mono Lake, California
Previous Article in Journal
Antimicrobial Activity of Microorganisms Isolated from Ant Nests of Lasius niger
Open AccessCommunication

Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review

1
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-0033, Japan
2
Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo 113-0033, Japan
*
Author to whom correspondence should be addressed.
Life 2020, 10(6), 92; https://doi.org/10.3390/life10060092
Received: 21 May 2020 / Revised: 16 June 2020 / Accepted: 20 June 2020 / Published: 22 June 2020
(This article belongs to the Section Medical Research)
The purinergic P2Y12 receptor regulates microglial activation, resulting in persistence and aggravation of pain in neuropathic and nociceptive pain models. We conducted a retrospective chart review to explore the analgesic potency of the P2Y12 receptor-specific antagonist, clopidogrel, for clinical management of postoperative pain in patients who underwent abdominal surgery. Twenty-seven patients with cardiovascular comorbidities, who underwent laparoscopic abdominal surgery and had ceased aspirin (ASP, n = 17) or clopidogrel (CLP, n = 10) for 14 days pre-operatively, were enrolled retrospectively. In both groups, the number of opioids and non-steroidal anti-inflammatory drugs (NSAIDs) consumed for managing postoperative pain was compared using the chi-square test and Mann–Whitney test. Our results showed that from postoperative day (POD) 0 to POD 3, the average numerical rating reflecting the postoperative pain was comparable between the two groups (CLP: 4.0 ± 1.4 vs. ASP: 3.7 ± 0.8, P-value = 0.56). However, at POD 7, opioid consumption in the CLP-treated group (fentanyl-equivalent dose: 0.49 ± 0.56 mg) was significantly lower than that in the ASP-treated group (1.48 ± 1.35 mg, P-value = 0.037). After reaching a stable state by repeated systemic administration, clopidogrel sustained the analgesic efficacy for a certain period. In conclusion, microglial P2Y12 receptors may mediate signal transduction of postoperative nociceptive pain and enhance clinical opioid analgesia. View Full-Text
Keywords: ATP receptor; P2Y12 receptor; clopidogrel; postoperative pain; central sensitisation ATP receptor; P2Y12 receptor; clopidogrel; postoperative pain; central sensitisation
Show Figures

Figure 1

MDPI and ACS Style

Tsuchida, R.; Sumitani, M.; Abe, H.; Ando, M.; Saita, K.; Hattori, K.; Mietani, K.; Inoue, R.; Uchida, K. Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review. Life 2020, 10, 92.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop