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Bioinformatics Analysis of Evolution and Human Disease Related Transposable Element-Derived microRNAs

by Hee-Eun Lee 1, Jae-Won Huh 1,2 and Heui-Soo Kim 3,4,*
1
National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea
2
Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon 34113, Korea
3
Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 46241, Korea
4
Institute of Systems Biology, Pusan National University, Busan 46241, Korea
*
Author to whom correspondence should be addressed.
Life 2020, 10(6), 95; https://doi.org/10.3390/life10060095
Received: 8 June 2020 / Revised: 22 June 2020 / Accepted: 23 June 2020 / Published: 25 June 2020
(This article belongs to the Special Issue Genomic Impact of Transposable Elements)
Transposable element (TE) has the ability to insert into certain parts of the genome, and due to this event, it is possible for TEs to generate new factors and one of these factors are microRNAs (miRNA). miRNAs are non-coding RNAs made up of 19 to 24 nucleotides and numerous miRNAs are derived from TE. In this study, to support general knowledge on TE and miRNAs derived from TE, several bioinformatics tools and databases were used to analyze miRNAs derived from TE in two aspects: evolution and human disease. The distribution of TEs in diverse species presents that almost half of the genome is covered with TE in mammalians and less than a half in other vertebrates and invertebrates. Based on selected evolution-related miRNAs studies, a total of 51 miRNAs derived from TE were found and analyzed. For the human disease-related miRNAs, total of 34 miRNAs derived from TE were organized from the previous studies. In summary, abundant miRNAs derived from TE are found, however, the function of miRNAs derived from TE is not informed either. Therefore, this study provides theoretical understanding of miRNAs derived from TE by using various bioinformatics tools. View Full-Text
Keywords: evolution; human disease; microRNA; transposable elements; transposable element derived microRNA evolution; human disease; microRNA; transposable elements; transposable element derived microRNA
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Lee, H.-E.; Huh, J.-W.; Kim, H.-S. Bioinformatics Analysis of Evolution and Human Disease Related Transposable Element-Derived microRNAs. Life 2020, 10, 95.

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