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Open AccessArticle

Validating the Use of Corifollitropin Alfa in Progestin-Primed Ovarian Stimulation Protocol on Normal and High Responders by Comparing with Conventional Antagonist Protocol: A Retrospective Study

1
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, 201, Shih-Pai Road Section 2, Taipei 112, Taiwan
2
Institute of Clinical Medicine, National Yang-Ming University, 155, Linong Street Section 2, Taipei 112, Taiwan
3
Division of Obstetrics and Gynecology, Faculty of Medicine, School of Medicine, National Yang-Ming University, 155, Linong Street Section 2, Taipei 112, Taiwan
*
Author to whom correspondence should be addressed.
Life 2020, 10(6), 90; https://doi.org/10.3390/life10060090
Received: 3 May 2020 / Revised: 16 June 2020 / Accepted: 19 June 2020 / Published: 21 June 2020
(This article belongs to the Special Issue Reproductive Health Concerns for Women)
Our previous study showed a satisfactory reproductive outcome resulting from the patient-friendly ovarian stimulation protocol using long-acting follicle stimulation hormone (FSH) plus oral medroxyprogesterone acetate (MPA). The present retrospective study aims to compare the efficacy of the patient-friendly ovarian stimulation protocol with that of the antagonist protocol on normal and high responders aged between 24 and 39 years in a tertiary fertility center in Taiwan. To prevent premature luteinizing hormone (LH) surge, oral MPA was given to patients in group 1 (n = 57), whereas antagonist protocol was applied to group 2 (n = 53). Duration and dosage of stimulation, number of injections and visits before trigger, incidence of premature LH surge, number of oocytes retrieved, fertilization rate, cleavage rate, rate of good embryos available, incidence of ovarian hyperstimulation syndrome, cumulative clinical pregnancy rate and live birth rate per retrieval were compared between groups. We conclude that our patient-friendly ovarian stimulation protocol with MPA demonstrates satisfactory stimulation and reproductive outcomes that are comparable to those of an antagonist protocol. View Full-Text
Keywords: progestin-primed ovarian stimulation (PPOS); long-acting FSH; patient-friendly; antagonist progestin-primed ovarian stimulation (PPOS); long-acting FSH; patient-friendly; antagonist
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MDPI and ACS Style

Huang, C.-Y.; Chen, G.-Y.; Shieh, M.-L.; Li, H.-Y. Validating the Use of Corifollitropin Alfa in Progestin-Primed Ovarian Stimulation Protocol on Normal and High Responders by Comparing with Conventional Antagonist Protocol: A Retrospective Study. Life 2020, 10, 90.

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