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The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis

1
Department of Orthopaedics and Trauma Surgery, Centre of Postgraduate Medical Education, Professor A. Gruca Teaching Hospital, Konarskiego 13, 05-400 Otwock, Poland
2
Department of Medical Biology, Stefan Cardinal Wyszynski National Institute of Cardiology, ul. Alpejska 42, 04-628 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Life 2020, 10(6), 94; https://doi.org/10.3390/life10060094
Received: 19 May 2020 / Revised: 14 June 2020 / Accepted: 23 June 2020 / Published: 25 June 2020
(This article belongs to the Section Medical Research)
In recent years, the interest in biological treatment of knee lesions has increased, especially the application of platelet-rich plasma is of particular note. The number of articles evaluating platelet-rich plasma (PRP) efficacy in the recovery of knee disorders and during knee surgery has exponentially increased over the last decade. A systematic review with meta-analyses was performed by assessing selected studies of local PRP injections to the knee joint. The study was completed in accordance with 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A multistep search of PubMed, Embase, Cochrane Database of Systematic Reviews, and Clinicaltrials.gov was performed to identify studies on knee surgery and knee lesion treatment with PRP. Of the 4004 articles initially identified, 357 articles focusing on knee lesions were selected and, consequently, only 83 clinical trials were analyzed using the revised Cochrane risk-of-bias tool to evaluate risk. In total, seven areas of meta-analysis reported a positive effect of PRP. Among them, 10 sub-analyses demonstrated significant differences in favor of PRP when compared to the control groups (p < 0.05). This study showed the positive effects of PRP, both on the recovery of knee disorders and during knee surgery; however further prospective and randomized studies with a higher number of subjects and with lower biases are needed. View Full-Text
Keywords: PRP; platelet-rich plasma; meniscus; anterior cruciate ligament (ACL); osteoarthritis; tendinopathy; arthroscopy; knee lesion; total knee arthroplasty; osteoarthritis (OA); meniscal repair PRP; platelet-rich plasma; meniscus; anterior cruciate ligament (ACL); osteoarthritis; tendinopathy; arthroscopy; knee lesion; total knee arthroplasty; osteoarthritis (OA); meniscal repair
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Trams, E.; Kulinski, K.; Kozar-Kaminska, K.; Pomianowski, S.; Kaminski, R. The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery—A Systematic Review and Meta-Analysis. Life 2020, 10, 94.

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