Cells, Volume 8, Issue 11 (November 2019) – 168 articles
Cover Story (view full-size image): Nuclear pore complexes (NPCs) are large protein assemblies which span the nuclear envelope and regulate nucleocytoplasmic transport. Research over the last 15 years has revealed an additional key function of the NPC and its constituent nucleoporins (Nups) in the regulation of gene expression via physical interactions with the genome. Although many of the precise mechanisms behind the gene regulatory roles of Nups remain enigmatic, one emerging trend is the apparent ability of Nups to influence chromatin structure. In the accompanying review, we discuss recent findings on this topic and highlight how this influence can occur via interactions between specific Nups and both repressive and activating histone modifying machinery, and at the level of chromatin compaction, through conserved interactions of Nups with chromatin remodeling enzymes. View this paper.
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