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Nuclear Pore Proteins in Regulation of Chromatin State

Department of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Cells 2019, 8(11), 1414; https://doi.org/10.3390/cells8111414 (registering DOI)
Received: 18 October 2019 / Revised: 6 November 2019 / Accepted: 7 November 2019 / Published: 9 November 2019
(This article belongs to the Special Issue Nuclear Organisation)
Nuclear pore complexes (NPCs) are canonically known to regulate nucleocytoplasmic transport. However, research efforts over the last decade have demonstrated that NPCs and their constituent nucleoporins (Nups) also interact with the genome and perform important roles in regulation of gene expression. It has become increasingly clear that many Nups execute these roles specifically through regulation of chromatin state, whether through interactions with histone modifiers and downstream changes in post-translational histone modifications, or through relationships with chromatin-remodeling proteins that can result in physical changes in nucleosome occupancy and chromatin compaction. This review focuses on these findings, highlighting the functional connection between NPCs/Nups and regulation of chromatin structure, and how this connection can manifest in regulation of transcription. View Full-Text
Keywords: nuclear pore; nucleoporin; chromatin; chromatin remodeling; histone modifications; chromatin compaction; gene expression; transcription; nuclear organization nuclear pore; nucleoporin; chromatin; chromatin remodeling; histone modifications; chromatin compaction; gene expression; transcription; nuclear organization
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MDPI and ACS Style

Kuhn, T.M.; Capelson, M. Nuclear Pore Proteins in Regulation of Chromatin State. Cells 2019, 8, 1414.

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