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The Role of MicroRNAs upon Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease

by Éva Boros 1 and István Nagy 1,2,*
1
Institute of Biochemistry, Biological Research Centre, 6726 Szeged, Hungary
2
Seqomics Biotechnology Ltd., 6782 Mórahalom, Hungary
*
Author to whom correspondence should be addressed.
Cells 2019, 8(11), 1461; https://doi.org/10.3390/cells8111461
Received: 13 October 2019 / Revised: 3 November 2019 / Accepted: 18 November 2019 / Published: 19 November 2019
Increasing evidence suggest the significance of inflammation in the progression of cancer, for example the development of colorectal cancer in Inflammatory Bowel Disease (IBD) patients. Long-lasting inflammation in the gastrointestinal tract causes serious systemic complications and breaks the homeostasis of the intestine, where the altered expression of regulatory genes and miRNAs trigger malignant transformations. Several steps lead from acute inflammation to malignancies: epithelial-to-mesenchymal transition (EMT) and inhibitory microRNAs (miRNAs) are known factors during multistage carcinogenesis and IBD pathogenesis. In this review, we outline the interactions between EMT components and miRNAs that may affect cancer development during IBD. View Full-Text
Keywords: Inflammatory Bowel Disease (IBD); epithelial-to-mesenchymal transition (EMT); microRNAs Inflammatory Bowel Disease (IBD); epithelial-to-mesenchymal transition (EMT); microRNAs
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Boros, É.; Nagy, I. The Role of MicroRNAs upon Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease. Cells 2019, 8, 1461.

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