The Role of MicroRNAs upon Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease
by
Éva Boros 1
and István Nagy 1,2,*
Éva Boros 1 and István Nagy 1,2,*
1
Institute of Biochemistry, Biological Research Centre, 6726 Szeged, Hungary
2
Seqomics Biotechnology Ltd., 6782 Mórahalom, Hungary
*
Author to whom correspondence should be addressed.
Cells 2019, 8(11), 1461; https://doi.org/10.3390/cells8111461
Received: 13 October 2019 / Revised: 3 November 2019 / Accepted: 18 November 2019 / Published: 19 November 2019
(This article belongs to the Special Issue The Molecular and Cellular Basis for Inflammatory Bowel Diseases (IBD))
Increasing evidence suggest the significance of inflammation in the progression of cancer, for example the development of colorectal cancer in Inflammatory Bowel Disease (IBD) patients. Long-lasting inflammation in the gastrointestinal tract causes serious systemic complications and breaks the homeostasis of the intestine, where the altered expression of regulatory genes and miRNAs trigger malignant transformations. Several steps lead from acute inflammation to malignancies: epithelial-to-mesenchymal transition (EMT) and inhibitory microRNAs (miRNAs) are known factors during multistage carcinogenesis and IBD pathogenesis. In this review, we outline the interactions between EMT components and miRNAs that may affect cancer development during IBD.
View Full-Text
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Boros, É.; Nagy, I. The Role of MicroRNAs upon Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease. Cells 2019, 8, 1461.
Show more citation formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
