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Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing
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Telomere Biology and Human Phenotype

1
University of Kent, School of Biosciences, Giles Lane, Canterbury, Kent, CT2-7NJ, UK
2
Department of Child Health, East Kent Hospitals University Foundation NHS Trust, William Harvey Hospital, Ashford, Kent, TN24-0LZ, UK
*
Author to whom correspondence should be addressed.
Cells 2019, 8(1), 73; https://doi.org/10.3390/cells8010073
Received: 24 December 2018 / Revised: 14 January 2019 / Accepted: 16 January 2019 / Published: 19 January 2019
(This article belongs to the Special Issue The Role of Telomere Biology in Aging and Human Disease)
Telomeres are nucleoprotein structures that cap the end of each chromosome arm and function to maintain genome stability. The length of telomeres is known to shorten with each cell division and it is well-established that telomere attrition is related to replicative capacity in vitro. Moreover, telomere loss is also correlated with the process of aging in vivo. In this review, we discuss the mechanisms that lead to telomere shortening and summarise telomere homeostasis in humans throughout a lifetime. In addition, we discuss the available evidence that shows that telomere shortening is related to human aging and the onset of age-related disease. View Full-Text
Keywords: telomeres; telomere length; aging; senescence telomeres; telomere length; aging; senescence
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MDPI and ACS Style

Turner, K.J.; Vasu, V.; Griffin, D.K. Telomere Biology and Human Phenotype. Cells 2019, 8, 73.

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