Table of Contents
Cancers, Volume 9, Issue 12 (December 2017)
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Cover Story (view full-size image) The unrestrained activation of ALK tyrosine kinase acts as an oncogenic driver in a growing [...] Read more. The unrestrained activation of ALK tyrosine kinase acts as an oncogenic driver in a growing spectrum of ALK-associated cancers. Thus, its targeted inactivation has been extensively studied and proved beneficial for patients. However, resistances to ALK oncogene inhibitors have been reported, which underlines the need for improved therapeutic options. Macro-autophagy, a highly conserved vesicular degradation process, was found to be induced upon diverse therapeutic stresses, in many different cancer types, and to harbor, in these settings, either cytoprotective or, oppositely, cytotoxic functions. Our review discusses the recent findings that correlate ALK-dependent malignancies with autophagy induction upon treatment. It emphasizes that the therapeutic modulation of autophagy could represent a promising new strategy to improve current treatments of ALK-cancers. View this paper