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Cancers, Volume 17, Issue 12

June-2 2025 - 162 articles

Cover Story: Radiotherapy has long been a cornerstone of cancer treatment; however, recent technological and biological advances are rapidly transforming its practice. In this review, we highlight key innovations—including adaptive radiotherapy, advanced imaging, artificial intelligence, proton and FLASH therapy, brachytherapy, theranostics, and radioimmunotherapy—that are redefining precision, personalization, and effectiveness in cancer care. By summarizing both emerging technologies and evolving clinical strategies, this work offers a comprehensive overview of the most promising directions shaping the future of radiation oncology. View this paper
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Articles (162)

  • Article
  • Open Access
638 Views
18 Pages

Predictive Factors Aiding in the Estimation of Intraoperative Resources in Gastric Cancer Oncologic Surgery

  • Alexandru Blidișel,
  • Mihai-Cătălin Roșu,
  • Andreea-Adriana Neamțu,
  • Bogdan Dan Totolici,
  • Răzvan-Ovidiu Pop-Moldovan,
  • Andrei Ardelean,
  • Valentin-Cristian Iovin,
  • Ionuț Flaviu Faur,
  • Cristina Adriana Dehelean and
  • Sorin Adalbert Dema
  • + 1 author

18 June 2025

Background/Objectives: Operating rooms represent valuable and pivotal units of any hospital. Therefore, their management affects healthcare service delivery through rescheduling, staff shortage/overtime, cost inefficiency, and patient dissatisfaction...

  • Article
  • Open Access
2 Citations
1,172 Views
20 Pages

Redefining the Use of Regorafenib and Trifluridine/Tipiracil Without Bevacizumab in Refractory Metastatic Colorectal Cancer: Findings from the ReTrITA Study

  • Carlo Signorelli,
  • Maria Alessandra Calegari,
  • Annunziato Anghelone,
  • Alessandro Passardi,
  • Chiara Gallio,
  • Alessandro Bittoni,
  • Jessica Lucchetti,
  • Lorenzo Angotti,
  • Emanuela Di Giacomo and
  • Ina Valeria Zurlo
  • + 21 authors

18 June 2025

Background: Regorafenib (R) and trifluridine/tipiracil (T) are approved treatments for metastatic colorectal cancer (mCRC) in refractory cases. However, the optimal sequencing of these agents is unknown. The ReTrITA study planned to assess the real-w...

  • Article
  • Open Access
811 Views
17 Pages

Dual-Plasma Discharge Tube for Synergistic Glioblastoma Treatment

  • William Murphy,
  • Alex Horkowitz,
  • Vikas Soni,
  • Camil Walkiewicz-Yvon and
  • Michael Keidar

18 June 2025

Background: Glioblastoma (GBM) resists current therapies due to its rapid proliferation, diffuse invasion, and heterogeneous cell populations. We previously showed that a single cold atmospheric plasma discharge tube (DT) reduces GBM viability via br...

  • Article
  • Open Access
3 Citations
801 Views
19 Pages

ISUP Grade Prediction of Prostate Nodules on T2WI Acquisitions Using Clinical Features, Textural Parameters and Machine Learning-Based Algorithms

  • Teodora Telecan,
  • Alexandra Chiorean,
  • Roxana Sipos-Lascu,
  • Cosmin Caraiani,
  • Bianca Boca,
  • Raluca Maria Hendea,
  • Teodor Buliga,
  • Iulia Andras,
  • Nicolae Crisan and
  • Monica Lupsor-Platon

18 June 2025

Background: Prostate cancer (PCa) represents a matter at the forefront of healthcare, being divided into clinically significant (csPCa) and indolent PCa based on prognostic and treatment options. Although multi-parametric magnetic resonance imaging (...

  • Article
  • Open Access
949 Views
13 Pages

KAT/3BP: A Metabolism-Targeting Agent with Single and Combination Activity in Aggressive B-Cell Lymphomas

  • Chiara Tarantelli,
  • Filippo Spriano,
  • Elisa Civanelli,
  • Luca Aresu,
  • Giorgia Risi,
  • Eleonora Cannas,
  • Omar Kayali,
  • Luciano Cascione,
  • Alberto J. Arribas and
  • Anastasios Stathis
  • + 2 authors

18 June 2025

Background/Objectives: Reprogramming of the cellular metabolism is a hallmark of cancer, offering therapeutic opportunities to target cancer cell vulnerabilities for therapeutic purposes. 3-Bromopyruvate (3BP) is a small alkylating agent that functio...

  • Article
  • Open Access
1 Citations
1,570 Views
15 Pages

A Pragmatic Grouping Model for Bone-Only De Novo Metastatic Breast Cancer (MetS Protocol MF22-03)

  • Berk Goktepe,
  • Berkay Demirors,
  • Kazim Senol,
  • Serdar Ozbas,
  • Efe Sezgin,
  • Anthony Lucci and
  • Atilla Soran

18 June 2025

De novo metastatic breast cancer (dnMBC) accounts for 3–10% of newly diagnosed cases, with 20–40% presenting as a bone-only metastatic disease, which can achieve survival outcomes exceeding 10 years with multimodal therapy. However, the r...

  • Retraction
  • Open Access
633 Views
2 Pages

RETRACTED: Kalicińska et al. Pneumonia in Patients with Chronic Lymphocytic Leukemia Treated with Venetoclax-Based Regimens: A Real-World Analysis of the Polish Adult Leukemia Group (PALG). Cancers 2024, 16, 4168

  • Elżbieta Kalicińska,
  • Paula Jabłonowska-Babij,
  • Marta Morawska,
  • Elżbieta Iskierka-Jażdżewska,
  • Joanna Drozd-Sokołowska,
  • Ewa Paszkiewicz-Kozik,
  • Łukasz Szukalski,
  • Judyta Strzała,
  • Urszula Gosik and
  • Jakub Dębski
  • + 4 authors

18 June 2025

The Cancers journal retracts the article titled “Pneumonia in Patients with Chronic Lymphocytic Leukemia Treated with Venetoclax-Based Regimens: A Real-World Analysis of the Polish Adult Leukemia Group (PALG)” [...]

  • Article
  • Open Access
1,134 Views
12 Pages

Mucin4 (MUC4) Antibody Labeled with an NIR Dye Brightly Targets Pancreatic Cancer Liver Metastases and Peritoneal Carcinomatosis

  • Sunidhi Jaiswal,
  • Siamak Amirfakhri,
  • Javier Bravo,
  • Keita Kobayashi,
  • Abhijit Aithal,
  • Sumbal Talib,
  • Kavita Mallya,
  • Maneesh Jain,
  • Aaron M. Mohs and
  • Robert M. Hoffman
  • + 2 authors

18 June 2025

Background/Objectives: Pancreatic cancer is the fourth leading cause of deaths related to cancer. It is a highly aggressive malignancy and often metastasizes quickly to other parts of the body and organs. The most effective cure is surgical resection...

  • Article
  • Open Access
1 Citations
3,154 Views
21 Pages

Lymph Node Reporting and Data System (LN-RADS)—Retrospective Evaluation for Ultrasound Classification of Superficial Lymph Nodes

  • Cezary Chudobiński,
  • Katarzyna Pasicz,
  • Małgorzata Hanke,
  • Adam Kaczmarek,
  • Mateusz Pajdziński,
  • Agnieszka Kołacińska-Wow,
  • Leszek Gottwald,
  • Wojciech Kuncman,
  • Michał Podgórski and
  • Andrzej Cieszanowski

18 June 2025

Introduction: The evaluation of lymph nodes (LNs) in patients with suspected oncological disease is a crucial factor influencing further diagnostics and management. However, there is a lack of a dedicated system for the precise and comprehensive asse...

  • Article
  • Open Access
1 Citations
1,809 Views
17 Pages

Papillary Thyroid Microcarcinoma in Thyroid Surgical Practice: Incidental vs. Non-Incidental: A Ten-Year Comparative Study

  • Amani A. Bashir,
  • Mohamed M. El-Zaheri,
  • Ahmad A. Bashir,
  • Luma Fayyad,
  • Aiman H. Obed,
  • Dima Alkam and
  • Abdalla Y. Bashir

18 June 2025

Background/Objectives: With evolving guidelines favoring de-escalation in the management of papillary thyroid microcarcinoma (PTMC), options such as active surveillance and minimally invasive procedures are now considered for patients with low-risk d...

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Cancers - ISSN 2072-6694