You are currently viewing a new version of our website. To view the old version click .

Cancers, Volume 16, Issue 6

March-2 2024 - 165 articles

Cover Story: The BCL2 inhibitor venetoclax combined with the hypomethylating agent azacitidine is the new therapeutic standard for elderly or unfit acute myeloid leukemia patients. Despite a 65% composite response rate, overall survival is about 14 months, underlying the need for new therapeutics with improved efficacy and low toxicity. Gene mutations associated with resistance or relapse are TP53, signaling mutations, and the newly described BAX mutations. Venetoclax-based triplet therapies, including IDH and FLT3 inhibitors or menin inhibitors, are under investigation to improve patient outcomes. A better comprehension of genomic and non-genomic evolution upon treatment and the interplay between genomic alterations and apoptosis will allow us to tackle resistance mechanisms in the future. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (165)

  • Article
  • Open Access
1,910 Views
16 Pages

Early Gastric Cancers in Central Norway 2001 to 2016—A Population-Based Study

  • Camilla J. Kvamme,
  • Thomas L. Stillingen,
  • Alina D. Sandø,
  • Patricia Mjønes,
  • Erling A. Bringeland and
  • Reidar Fossmark

20 March 2024

Early gastric cancers (EGCs) are confined to the gastric mucosa and submucosa irrespective of lymph node metastases and constitute only a minor proportion of gastric cancer in Western countries. We aimed to characterize EGCs and assess the survival o...

  • Review
  • Open Access
27 Citations
8,065 Views
27 Pages

Insight into Iron, Oxidative Stress and Ferroptosis: Therapy Targets for Approaching Anticancer Strategies

  • Marialuisa Piccolo,
  • Maria Grazia Ferraro,
  • Federica Iazzetti,
  • Rita Santamaria and
  • Carlo Irace

20 March 2024

Based on the multifaceted molecular machinery that tightly controls iron cellular homeostasis, this review delves into its paradoxical, potentially dangerous role in biological systems, with a special focus on double-edged sword correlations with can...

  • Article
  • Open Access
2 Citations
2,294 Views
9 Pages

Diagnosis of Metastatic Non-Small Cell Lung Cancer during Hospitalization: Missed Opportunity for Optimal Supportive Care?

  • Shristi Upadhyay Banskota,
  • Jonathan Q. Trinh,
  • Elizabeth Lyden,
  • Conor Houlihan,
  • Samia Asif,
  • Omar Abughanimeh and
  • Benjamin A. Teply

20 March 2024

Purpose: The usual workup for patients newly diagnosed with advanced non-small cell lung cancer (NSCLC) occurs in the ambulatory setting. A subset of patients present with acute care needs and receive the diagnosis while hospitalized. Palliative ther...

  • Article
  • Open Access
6 Citations
2,812 Views
13 Pages

20 March 2024

Purpose: This retrospective cohort study aims to compare the quality of life (QoL) in patients with nasopharyngeal cancer (NPC) treated with intensity-modulated proton therapy (IMPT) versus volumetric modulated arc therapy (VMAT) at different time po...

  • Article
  • Open Access
5 Citations
3,012 Views
9 Pages

In-Hospital Mortality and Associated Factors among Colorectal Cancer Patients in Germany

  • Karel Kostev,
  • Sarah Krieg,
  • Andreas Krieg,
  • Tom Luedde,
  • Sven H. Loosen and
  • Christoph Roderburg

20 March 2024

Background: In the present study, we used the data from 14 hospitals to systematically evaluate the in-hospital mortality of patients with colorectal cancer as well as its influencing factors in Germany. Methods: This multicenter cross-sectional stud...

  • Communication
  • Open Access
3 Citations
2,415 Views
10 Pages

Contrast Clearance Analysis (CCA) to Assess Viable Tumour following Stereotactic Radiosurgery (SRS) to Brain Metastasis in Non-Small Cell Lung Cancer (NSCLC)

  • Shybi Mohamedkhan,
  • Sumeet Hindocha,
  • James de Boisanger,
  • Thomas Millard,
  • Liam Welsh,
  • Philip Rich,
  • Andrew D. MacKinnon,
  • Nicholas Williams,
  • Bhupinder Sharma and
  • Nicola Rosenfelder
  • + 1 author

20 March 2024

Background and Objective: Brain metastases are common in lung cancer and increasingly treated using targeted radiotherapy techniques such as stereotactic radiosurgery (SRS). Using MRI, post-SRS changes may be difficult to distinguish from progressive...

  • Review
  • Open Access
7 Citations
4,908 Views
18 Pages

Reviewing the Landscape of Cancer Survivorship: Insights from Dr. Lidia Schapira’s Programs and Beyond

  • Viviana Cortiana,
  • Rabab Hunaid Abbas,
  • Soumiya Nadar,
  • Diksha Mahendru,
  • Jade Gambill,
  • Gayathri Pramil Menon,
  • Chandler H. Park and
  • Yan Leyfman

20 March 2024

The constantly escalating population of cancer survivors worldwide has prompted a focused exploration of their unique needs and experiences within the context of healthcare medicine. This review initiates its analysis inspired by Dr. Lidia Schapira&r...

  • Review
  • Open Access
5 Citations
7,262 Views
23 Pages

Mutations in the Serine/Threonine Kinase BRAF: Oncogenic Drivers in Solid Tumors

  • Paola Roa,
  • Nicole Virginia Bremer,
  • Valentina Foglizzo and
  • Emiliano Cocco

20 March 2024

Since their discovery in 2002, BRAF mutations have been identified as clear drivers of oncogenesis in several cancer types. Currently, their incidence rate is nearly 7% of all solid tumors with BRAF V600E constituting approximately 90% of these diagn...

  • Review
  • Open Access
28 Citations
5,671 Views
17 Pages

Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma: A Literature Review

  • Haider Ghazanfar,
  • Nismat Javed,
  • Abeer Qasim,
  • George Sarin Zacharia,
  • Ali Ghazanfar,
  • Abhilasha Jyala,
  • Elona Shehi and
  • Harish Patel

20 March 2024

The prevalence of metabolic-associated fatty liver disease (MAFLD) is increasing globally due to factors such as urbanization, obesity, poor nutrition, sedentary lifestyles, healthcare accessibility, diagnostic advancements, and genetic influences. R...

  • Article
  • Open Access
3 Citations
2,592 Views
15 Pages

Investigating the Use of a Liquid Immunogenic Fiducial Eluter Biomaterial in Cervical Cancer Treatment

  • Michele Moreau,
  • Lensa S. Keno,
  • Debarghya China,
  • Serena Mao,
  • Shahinur Acter,
  • Gnagna Sy,
  • Hamed Hooshangnejad,
  • Kwok Fan Chow,
  • Erno Sajo and
  • Jacques Walker
  • + 5 authors

20 March 2024

Globally, cervical cancer is the fourth leading cancer among women and is dominant in resource-poor settings in its occurrence and mortality. This study focuses on developing liquid immunogenic fiducial eluter (LIFE) Biomaterial with components that...

of 17

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Cancers - ISSN 2072-6694