Cancers, Volume 12, Issue 12 (December 2020) – 385 articles
Cover Story (view full-size image): Cancer initiation, growth, and invasion are promoted by multiple mechanisms, including non-coding RNA (ncRNA)-dependent regulatory pathways. Deregulated expression of ncRNAs including long-non-coding RNAs (lncRNAs), competing endogenous RNAS (ceRNAs), and microRNAs (miRNAs) can promote malignancies by altering the cell cycle and apoptotic pathways to facilitate cellular proliferation. LncRNAs can alter gene expression through direct targeting of messenger RNAs (mRNAs), recruitment of epigenetic regulators to repress or activate transcription, or by functioning as ceRNAs to quench tumor suppressive miRNAs. Consequently, abnormal levels of ncRNAs and their ability to alter the epigenome can stimulate tumorigenesis and hematological malignancies. Therefore, targeting ncRNAs could be the foundation for developing new cancer therapies. View this paper.
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