High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. High NRF2 Expression Is Significantly Associated with Better Survival in ER-Positive/HER2-Negative Breast Cancer
2.2. High NRF2 Expression Is Significantly Associated with Lower Nottingham Pathological Grade, and ER-Positive/HER2-Negative and TNBC Subtype
2.3. High NRF2 Tumors Are Enriched with Inflammation- and Immune-Related Gene Sets in ER-Positive/HER2-Negative Breast Cancer
2.4. NRF2 Is Expressed in Immune Cells as well as Cancer Cells, and High NRF2 Tumors Are Infiltrated with Anti-Cancer Immune Cells and Stromal Cells
2.5. NRF2 Expression Was Significantly Associated with Treatment Response In Vitro, but Association Was Noted with Pathological Complete Response (pCR) after Neoadjuvant Chemotherapy (NAC)
2.6. High NRF2 Tumors Are Significantly Associated with High Expression of Immune Checkpoint Molecules in ER-Positive/HER2-Negative Breast Cancer
3. Discussion
4. Materials and Methods
4.1. Cohorts Used for Analyses
4.2. Data of Gene Expression and Treatment Response of Cell Lines
4.3. Tumor-Infiltrating Cells Scoring Using xCell Algorithm and Cytolytic Activity Score (CYT)
4.4. Gene Set Expression Analyses
4.5. Other
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
Abbreviations
References
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Oshi, M.; Angarita, F.A.; Tokumaru, Y.; Yan, L.; Matsuyama, R.; Endo, I.; Takabe, K. High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer. Cancers 2020, 12, 3856. https://doi.org/10.3390/cancers12123856
Oshi M, Angarita FA, Tokumaru Y, Yan L, Matsuyama R, Endo I, Takabe K. High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer. Cancers. 2020; 12(12):3856. https://doi.org/10.3390/cancers12123856
Chicago/Turabian StyleOshi, Masanori, Fernando A. Angarita, Yoshihisa Tokumaru, Li Yan, Ryusei Matsuyama, Itaru Endo, and Kazuaki Takabe. 2020. "High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer" Cancers 12, no. 12: 3856. https://doi.org/10.3390/cancers12123856