Vol. 12, Iss 11 | Cancers

Article

18 Citations

3,881 Views

14 Pages

Total Pelvic Exenteration, Cytoreductive Surgery, and Hyperthermic Intraperitoneal Chemotherapy for Rectal Cancer with Associate Peritoneal Metastases: Surgical Strategies to Optimize Safety

Jean-Jacques Tuech,
Jean Pinson,
François-Xavier Nouhaud,
Gregory Wood,
Thomas Clavier,
Jean-Christophe Sabourin,
Frederic Di Fiore,
Matthieu Monge,
Eloïse Papet and
Julien Coget

Cancers2020, 12(11), 3478;https://doi.org/10.3390/cancers12113478

23 November 2020

Background: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a curative treatment option for patients with peritoneal carcinomatosis. Total pelvic exenteration (TPE) is an established treatment option for locally...

Full Article

Article

20 Citations

4,961 Views

12 Pages

Breast Cancer Mortality among Women with a BRCA1 or BRCA2 Mutation in a Magnetic Resonance Imaging Plus Mammography Screening Program

Ellen Warner,
Siqi Zhu,
Donald B. Plewes,
Kimberley Hill,
Elizabeth A. Ramsay,
Petrina A. Causer,
Jean Seely,
Roberta A. Jong,
Pamela Lenkov and
Christine Elser
+ 5 authors

Cancers2020, 12(11), 3479;https://doi.org/10.3390/cancers12113479

23 November 2020

Annual breast magnetic resonance imaging (MRI) plus mammography is the standard of care for screening women with inherited BRCA1/2 mutations. However, long-term breast cancer-related mortality with screening is unknown. Between 1997 and June 2011, 48...

Full Article

Article

27 Citations

3,657 Views

15 Pages

Pre-Existing Cardiovascular Conditions as Clinical Predictors of Myocarditis Reporting with Immune Checkpoint Inhibitors: A VigiBase Study

Roberta Noseda,
Lorenzo Ruinelli,
Linda C. van der Gaag and
Alessandro Ceschi

Cancers2020, 12(11), 3480;https://doi.org/10.3390/cancers12113480

23 November 2020

Although rare, immune checkpoint inhibitor (ICI)-related myocarditis can be life-threatening, even fatal. In view of increased ICI prescription, identification of clinical risk factors for ICI-related myocarditis is of primary importance. This study...

Full Article

Review

14 Citations

3,276 Views

24 Pages

Precision Approaches in the Management of Colorectal Cancer: Current Evidence and Latest Advancements towards Individualizing the Treatment

Rebecca A. Shuford,
Ashley L. Cairns and
Omeed Moaven

Cancers2020, 12(11), 3481;https://doi.org/10.3390/cancers12113481

23 November 2020

The genetic and molecular underpinnings of metastatic colorectal cancer have been studied for decades, and the applicability of these findings in clinical decision making continues to evolve. Advancements in translating molecular studies have provide...

Full Article

Article

11 Citations

4,543 Views

20 Pages

A Combined Systemic Strategy for Overcoming Cisplatin Resistance in Head and Neck Cancer: From Target Identification to Drug Discovery

Yin-Ju Chen,
Guo-Rung You,
Meng-Yu Lai,
Long-Sheng Lu,
Chang-Yu Chen,
Lai-Lei Ting,
Hsin-Lun Lee,
Yuzuka Kanno,
Jeng-Fong Chiou and
Ann-Joy Cheng

Cancers2020, 12(11), 3482;https://doi.org/10.3390/cancers12113482

23 November 2020

Cisplatin is the first-line chemotherapy agent for head and neck cancer (HNC), but its therapeutic effects are hampered by its resistance. In this study, we employed systemic strategies to overcome cisplatin resistance (CR) in HNC. CR cells derived f...

Full Article

Review

13 Citations

3,509 Views

13 Pages

Pigment Epithelium-Derived Factor and Sex Hormone-Responsive Cancers

Naomi Brook,
Emily Brook,
Crispin R. Dass,
Arlene Chan and
Arun Dharmarajan

Cancers2020, 12(11), 3483;https://doi.org/10.3390/cancers12113483

23 November 2020

Oestrogens and androgens play important roles in normal and cancerous tissue and have been shown to negatively regulate pigment epithelium-derived factor (PEDF) expression in sex hormone-responsive tumours. PEDF suppresses tumour growth and its downr...

Full Article

Article

14 Citations

5,782 Views

26 Pages

Calcitriol in the Presence of Conditioned Media from Metastatic Breast Cancer Cells Enhances Ex Vivo Polarization of M2 Alternative Murine Bone Marrow-Derived Macrophages

Artur Anisiewicz,
Natalia Łabędź,
Izabela Krauze and
Joanna Wietrzyk

Cancers2020, 12(11), 3485;https://doi.org/10.3390/cancers12113485

23 November 2020

In this study, we differentiated murine bone marrow-derived macrophages (BMDMs) into M0, M1, and M2 in the presence or absence of calcitriol. Real-time PCR analysis of gene expression, FACS analysis of surface markers, and chemokine/cytokine producti...

Full Article

Article

11 Citations

3,140 Views

20 Pages

Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC

Monique Meyenberg Cunha-de Padua,
Lucilla Fabbri,
Maeva Dufies,
Sandra Lacas-Gervais,
Julie Contenti,
Charles Voyton,
Sofia Fazio,
Marie Irondelle,
Baharia Mograbi and
Matthieu Rouleau
+ 8 authors

Cancers2020, 12(11), 3484;https://doi.org/10.3390/cancers12113484

23 November 2020

Metabolic flexibility is the ability of a cell to adapt its metabolism to changes in its surrounding environment. Such adaptability, combined with apoptosis resistance provides cancer cells with a survival advantage. Mitochondrial voltage-dependent a...

Full Article

Article

14 Citations

3,262 Views

11 Pages

Circulating Tumour DNA in Advanced Melanoma Patients Ceasing PD1 Inhibition in the Absence of Disease Progression

Lydia Warburton,
Leslie Calapre,
Michelle R. Pereira,
Anna Reid,
Cleo Robinson,
Benhur Amanuel,
Mel Ziman,
Michael Millward and
Elin Gray

Cancers2020, 12(11), 3486;https://doi.org/10.3390/cancers12113486

23 November 2020

Immunotherapy is an important and established treatment option for patients with advanced melanoma. Initial anti-PD1 trials arbitrarily defined a two-year treatment duration, but a shorter treatment duration may be appropriate. In this study, we retr...

Full Article

Article

14 Citations

3,963 Views

16 Pages

Clinicopathological and Molecular Profiles of Sporadic Microsatellite Unstable Colorectal Cancer with or without the CpG Island Methylator Phenotype (CIMP)

Shih-Ching Chang,
Anna Fen-Yau Li,
Pei-Ching Lin,
Chun-Chi Lin,
Hung-Hsin Lin,
Shen-Chieh Huang,
Chien-Hsing Lin,
Wen-Yi Liang,
Wei-Shone Chen and
Jeng-Kai Jiang
+ 3 authors

Cancers2020, 12(11), 3487;https://doi.org/10.3390/cancers12113487

23 November 2020

Background: The 5’-C-phosphate-G-3’ island methylator phenotype (CIMP) is a specific phenotype of colorectal cancer (CRC) associated with microsatellite instability-high (MSI-high) tumors. Methods: In this study, we determined the CIMP st...

Full Article

Cancers, Volume 12, Issue 11

Articles (412)

Total Pelvic Exenteration, Cytoreductive Surgery, and Hyperthermic Intraperitoneal Chemotherapy for Rectal Cancer with Associate Peritoneal Metastases: Surgical Strategies to Optimize Safety

Breast Cancer Mortality among Women with a BRCA1 or BRCA2 Mutation in a Magnetic Resonance Imaging Plus Mammography Screening Program

Pre-Existing Cardiovascular Conditions as Clinical Predictors of Myocarditis Reporting with Immune Checkpoint Inhibitors: A VigiBase Study

Precision Approaches in the Management of Colorectal Cancer: Current Evidence and Latest Advancements towards Individualizing the Treatment

A Combined Systemic Strategy for Overcoming Cisplatin Resistance in Head and Neck Cancer: From Target Identification to Drug Discovery

Pigment Epithelium-Derived Factor and Sex Hormone-Responsive Cancers

Calcitriol in the Presence of Conditioned Media from Metastatic Breast Cancer Cells Enhances Ex Vivo Polarization of M2 Alternative Murine Bone Marrow-Derived Macrophages

Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC

Circulating Tumour DNA in Advanced Melanoma Patients Ceasing PD1 Inhibition in the Absence of Disease Progression

Clinicopathological and Molecular Profiles of Sporadic Microsatellite Unstable Colorectal Cancer with or without the CpG Island Methylator Phenotype (CIMP)