Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer
Abstract
:1. Introduction: General Considerations for DSB Repair Pathway Utilization
2. Characteristics of Pathways Processing DSBs
2.1. General Considerations
2.2. Rapid Removal of DNA Ends by c-NHEJ
2.3. DNA-End-Resection-Dependent Rejoining of DSBs by GC, SSA, and Alt-EJ
2.3.1. Gene Conversion (GC)
2.3.2. Single Strand Annealing (SSA)
2.3.3. Alternative End-Joining (Alt-EJ)
3. IR Induces DSBs of Different Complexity
4. A Subset of DSBs Induced by High LET IR Compromises c-NHEJ
5. DSB Clusters Suppress c-NHEJ and Cause Translocations
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Iliakis, G.; Mladenov, E.; Mladenova, V. Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer. Cancers 2019, 11, 1671. https://doi.org/10.3390/cancers11111671
Iliakis G, Mladenov E, Mladenova V. Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer. Cancers. 2019; 11(11):1671. https://doi.org/10.3390/cancers11111671
Chicago/Turabian StyleIliakis, George, Emil Mladenov, and Veronika Mladenova. 2019. "Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer" Cancers 11, no. 11: 1671. https://doi.org/10.3390/cancers11111671