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Open AccessFeature PaperReview

Animal Models of Hepatocellular Carcinoma Prevention

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy
Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital, 40138 Bologna, Italy
Department of Life Sciences and Biotechnologies, University of Ferrara, 44121 Ferrara, Italy
Authors to whom correspondence should be addressed.
Cancers 2019, 11(11), 1792;
Received: 17 October 2019 / Revised: 8 November 2019 / Accepted: 10 November 2019 / Published: 14 November 2019
(This article belongs to the Special Issue Models of Experimental Liver Cancer)
Hepatocellular carcinoma (HCC) is a deadly disease and therapeutic efficacy in advanced HCC is limited. Since progression of chronic liver disease to HCC involves a long latency period of a few decades, a significant window of therapeutic opportunities exists for prevention of HCC and improve patient prognosis. Nonetheless, there has been no clinical advancement in instituting HCC chemopreventive strategies. Some of the major challenges are heterogenous genetic aberrations of HCC, significant modulation of tumor microenvironment and incomplete understanding of HCC tumorigenesis. To this end, animal models of HCC are valuable tools to evaluate biology of tumor initiation and progression with specific insight into molecular and genetic mechanisms involved. In this review, we describe various animal models of HCC that facilitate effective ways to study therapeutic prevention strategies that have translational potential to be evaluated in a clinical context. View Full-Text
Keywords: hepatocellular carcinoma; prevention; animal models hepatocellular carcinoma; prevention; animal models
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Shankaraiah, R.C.; Gramantieri, L.; Fornari, F.; Sabbioni, S.; Callegari, E.; Negrini, M. Animal Models of Hepatocellular Carcinoma Prevention. Cancers 2019, 11, 1792.

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