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Nucleocytoplasmic Shuttling of STATs. A Target for Intervention?

1
Institute of Biochemistry and Molecular Biology, RWTH Aachen University, 52074 Aachen, Germany
2
Confocal Microscopy Facility, Interdisciplinary Center for Clinical Research IZKF, RWTH Aachen University, 52074 Aachen, Germany
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(11), 1815; https://doi.org/10.3390/cancers11111815
Received: 3 September 2019 / Revised: 8 November 2019 / Accepted: 13 November 2019 / Published: 19 November 2019
(This article belongs to the Special Issue Targeting STAT3 and STAT5 in Cancer)
Signal transducer and activator of transcription (STAT) proteins are transcription factors that in the latent state are located predominantly in the cytoplasm. Activation of STATs through phosphorylation of a single tyrosine residue results in nuclear translocation. The requirement of tyrosine phosphorylation for nuclear accumulation is shared by all STAT family members but mechanisms of nuclear translocation vary between different STATs. These differences offer opportunities for specific intervention. To achieve this, the molecular mechanisms of nucleocytoplasmic shuttling of STATs need to be understood in more detail. In this review we will give an overview on the various aspects of nucleocytoplasmic shuttling of latent and activated STATs with a special focus on STAT3 and STAT5. Potential targets for cancer treatment will be identified and discussed. View Full-Text
Keywords: STAT3; STAT5; nuclear pore complex; nuclear transport receptors; nucleocytoplasmic shuttling; cancer; targeting STAT3; STAT5; nuclear pore complex; nuclear transport receptors; nucleocytoplasmic shuttling; cancer; targeting
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Ernst, S.; Müller-Newen, G. Nucleocytoplasmic Shuttling of STATs. A Target for Intervention? Cancers 2019, 11, 1815.

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