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Micromachines, Volume 15, Issue 2
February 2024 - 124 articles
Cover Story: Candida albicans’ infection presents a global health and economic challenge, afflicting women with discomfort, mental distress, and fatalities in immunocompromised individuals. Current detection methods, relying on microscopy, culturing, or DNA amplification are prohibitively expensive, slow, and inaccessible in remote areas. Our study unveils an affordable, rapid detection platform. Leveraging aptamers for their selective recognition of 1,3-β-D glucan molecules, a hallmark of C. albicans cell walls, we employ aptamer-tagged gold core–shell nanoparticles. In the presence of a pathogen, these nanoparticles aggregate, causing a distinctive blue colour perceptible to the naked eye. This innovation holds the potential to transform Candida albicans diagnostics, particularly in underserved regions, thereby advancing women's healthcare. View this paper
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Micromachines - ISSN 2072-666X