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Nutrients, Volume 9, Issue 10 (October 2017)
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Cover Story (view full-size image) Cancer is a multifactorial condition with genetic and environmental factors modulating [...] Read more. Cancer is a multifactorial condition with genetic and environmental factors modulating tumorogenesis. Nutrients are considered among the most important risk factors in colorectal cancer. The direct association of an unhealthy diet with obesity and dysbiosis opens new routes in the understanding of how nutrients influence cancer prognosis. In the "omics" era, traditional nutrition has been evolved to precision nutrition. Together with classical diet-nutrition-related genes, lipid-metabolism-related genes have acquired relevant interest in precision nutrition studies. A wide range of tumorogenic steps are influenced by lipid metabolism, both in primary tumours and distal metastasis. The extent to which genetic variants, along with intake of dietary components affect risk of colorectal neoplasia is under investigation and new therapeutic or preventive applications must be explored in colorectal cancer models. View this paper