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Translational Aspects of Diet and Non-Alcoholic Fatty Liver Disease
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Non-Alcoholic Fatty Liver Disease and Nutritional Implications: Special Focus on Copper

Francesco Balsano Foundation, 00185 Rome, Italy
Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, 00185 Rome, Italy
Author to whom correspondence should be addressed.
Nutrients 2017, 9(10), 1137;
Received: 26 July 2017 / Revised: 25 September 2017 / Accepted: 8 October 2017 / Published: 18 October 2017
(This article belongs to the Special Issue Nutrition and Non-alcoholic Fatty Liver Disease)
Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipids in hepatocytes, due to excessive fatty acid influx from adipose tissue, de novo hepatic lipogenesis, in addition to excessive dietary fat and carbohydrate intake. Chronic hepatic lipid overload induces mitochondrial oxidative stress and cellular damage leading the development of NAFLD into a more severe liver disease condition, non-alcoholic steato-hepatitis (NASH). In turn, this can progress to cirrhosis and hepatocellular carcinoma (HCC). Among others, copper is one of the main bio-metals required for the preponderance of the enzymes involved in physiological redox reactions, which primarily occurs during mitochondrial respiration. Thus, copper homeostasis could be considered a target point for counteracting the progression of NAFLD. Accordingly, many diseases are correlated to unbalanced copper levels and, actually, some clinical trials are examining the use of copper chelating agents. Currently, no pharmacological interventions are approved for NAFLD, but nutritional and lifestyle modifications are always recommended. Fittingly, antioxidant food agents recognized to improve NAFLD and its complications have been described in the literature to bind copper. Therefore, this review describes the role of nutrition in the development and progression of NAFLD with a particular focus on copper and copper-binding antioxidant compounds against NAFLD. View Full-Text
Keywords: NAFLD; copper; ROS; nutrients; antioxidants; lipids; liver NAFLD; copper; ROS; nutrients; antioxidants; lipids; liver
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MDPI and ACS Style

Antonucci, L.; Porcu, C.; Iannucci, G.; Balsano, C.; Barbaro, B. Non-Alcoholic Fatty Liver Disease and Nutritional Implications: Special Focus on Copper. Nutrients 2017, 9, 1137.

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