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Infectious Disease Reports, Volume 17, Issue 3

2025 June - 34 articles

Cover Story: Enterovirus-D68 (EV-D68) and rhinoviruses significantly contribute to respiratory illnesses in children and can lead to severe lower respiratory tract infections. These viruses present a spectrum of clinical features, from asymptomatic infection to mild upper respiratory symptoms and severe lower respiratory tract involvement. No specific antiviral treatments are currently approved for EV-D68 and rhinovirus infections. While supportive care remains the mainstay of treatment, antiviral agents offer potential therapeutic options in the future. This review aims to consolidate current knowledge on the antiviral options under investigation. We conducted a comprehensive literature review, analyzing ongoing research into antiviral agents targeting EV-D68 and rhinovirus infections. View this paper
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Articles (34)

  • Case Report
  • Open Access
1,459 Views
10 Pages

Polylactic Acid Membranes, a Novel Adjunct Treatment for Bullous Impetigo

  • Ana Lorena Novoa-Moreno,
  • Mario Aurelio Martinez-Jimenez,
  • Arturo Ortiz-Alvarez,
  • Natalia Sanchez-Olivo,
  • Victor Manuel Loza-Gonzalez and
  • Jose Luis Ramirez-GarciaLuna

Impetigo is a highly contagious bacterial skin infection characterized by blistering and erosions that can lead to significant discomfort and complications. The standard treatment includes topical or systemic antibiotics, but severe cases may require...

  • Commentary
  • Open Access
1,101 Views
8 Pages

Background: This commentary analyzes demographic, clinical, and occupational characteristics associated with Ebola virus disease (EVD) outcomes during the 2018–2020 outbreak in the Democratic Republic of Congo (DRC). Methods: A total of 3477 EV...

  • Article
  • Open Access
2,947 Views
12 Pages

SARS-CoV-2 Did Not Spread Through Dental Clinics During the COVID-19 Pandemic in Japan

  • Yasuhiro Tsubura,
  • Yuske Komiyama,
  • Saori Ohtani,
  • Toshiki Hyodo,
  • Ryo Shiraishi,
  • Shuma Yagisawa,
  • Erika Yaguchi,
  • Maki Tsubura-Okubo,
  • Hajime Houzumi and
  • Hitoshi Kawamata
  • + 6 authors

Background: Dental professionals were thought to have the most significant risk of coronavirus infection during the pandemic. Since the first Coronavirus Disease 2019 (COVID-19) patient was detected in Japan in January 2020, Japan has faced several w...

  • Article
  • Open Access
3 Citations
1,365 Views
14 Pages

Validation of a Questionnaire on the Post-COVID-19 Condition (Long COVID): A Cross-Sectional Study in Italy

  • Angelo Cianciulli,
  • Emanuela Santoro,
  • Roberta Manente,
  • Antonietta Pacifico,
  • Gianni Comunale,
  • Marika Finizio,
  • Mario Capunzo,
  • Francesco De Caro,
  • Gianluigi Franci and
  • Giovanni Boccia
  • + 1 author

Background/Objectives: Long COVID is a condition that was initially recognized by social support groups, and later by the scientific and medical communities. It affects COVID-19 survivors at various levels of severity, including young people, childre...

  • Article
  • Open Access
1 Citations
2,569 Views
18 Pages

Demographical and Clinical Characteristics, Risk Factors, and Prognosis of Adult Patients with Herpes Zoster in Türkiye: A Retrospective, Multi-Center Study (VARICOMP-Adult Study)

  • Esin Senol,
  • Alpay Azap,
  • Selda Sayin Kutlu,
  • Murat Kutlu,
  • Ayse Erbay,
  • Pelin Kocyigit,
  • Emine Colgecen,
  • Ozlem Ozbagcivan,
  • Nilsel Ilter and
  • Ener Cagri Dinleyici
  • + 6 authors

Introduction: Over the past few decades, the rising incidence of herpes zoster (HZ) rates appears to have been a global phenomenon. In Türkiye, there is a lack of comprehensive studies addressing the HZ burden of disease, risk factors, and clini...

  • Article
  • Open Access
1 Citations
1,106 Views
11 Pages

The New Reality of Infective Endocarditis: Changes in Patient Demographics and Outcomes in South Carolina

  • Grant Garrison,
  • Julie Royer,
  • Max Habicht,
  • Sarah Battle,
  • Hana R. Winders,
  • Kayla Antosz,
  • Anna-Kathryn Burch,
  • Majdi N. Al-Hasan,
  • Julie Ann Justo and
  • Pamela Bailey

Background: Rising rates of opioid use disorder (OUD), usually via injection, has resulted in younger patients being diagnosed with infective endocarditis (IE), with unique treatment challenges. Methods: This retrospective ecological study analyzed h...

  • Review
  • Open Access
1 Citations
2,023 Views
16 Pages

Gut Microbiome in Pulmonary Arterial Hypertension—An Emerging Frontier

  • Sasha Z. Prisco,
  • Suellen D. Oliveira,
  • E. Kenneth Weir,
  • Thenappan Thenappan and
  • Imad Al Ghouleh

Pulmonary arterial hypertension (PAH) is an irreversible disease characterized by vascular and systemic inflammation, ultimately leading to right ventricular failure. There is a great need for adjunctive therapies to extend survival for PAH patients....

  • Article
  • Open Access
1 Citations
1,512 Views
19 Pages

Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction

  • Amanda K. Garcia,
  • Noelia C. Lujea,
  • Javaria Baig,
  • Eli Heath,
  • Minh T. Nguyen,
  • Mario Rodriguez,
  • Preston Campbell,
  • Isabel Castro Piedras,
  • Edu Suarez Martinez and
  • Sharilyn Almodovar

Background: Human Immunodeficiency Virus (HIV) infections remain a source of cardiopulmonary complications among people receiving antiretroviral therapy. Still to this day, pulmonary hypertension (PH) severely affects the prognosis in this patient po...

  • Review
  • Open Access
2 Citations
4,801 Views
31 Pages

A Comprehensive Review of Progress in Preventing Urinary Infections Associated with the Use of Urinary Catheters: A Dual Analysis of Publications and Patents

  • Brunella Corrado,
  • Aniello Cammarano,
  • Stefania Dello Iacono,
  • Emilia Renzi,
  • Rosalba Moretta,
  • Maria Emilia Mercurio,
  • Laura Ascione,
  • Annunziata Cummaro,
  • Caterina Meglio and
  • Luigi Nicolais

Catheter-associated urinary tract infections (CAUTIs), caused by microbial colonization of catheter surfaces, are among the most common healthcare-associated infections and significantly strain healthcare systems worldwide. This review aimed to provi...

  • Article
  • Open Access
1 Citations
1,810 Views
11 Pages

Canine Leptospirosis in Flood-Affected Areas of Southern Brazil: Molecular Assessment and Public Health Implications

  • Gabriela Merker Breyer,
  • Nathasha Noronha Arechavaleta,
  • Bruna Corrêa da Silva,
  • Maria Eduarda Rocha Jacques da Silva,
  • Mariana Costa Torres,
  • Laura Cadó Nemitz,
  • Rafaela da Rosa Marques,
  • Fernando Borges Meurer,
  • Gabriela Amanda Linden and
  • Franciele Maboni Siqueira
  • + 1 author

Background: Southern Brazil faced massive rains and floods in May 2024, which led to social, infrastructural, and One Health issues affecting over 478 municipalities and 2.3 million people. Exposure to floodwater increased the risk of bacterial infec...

  • Case Report
  • Open Access
1 Citations
1,487 Views
12 Pages

Tropheryma whipplei and Giardia intestinalis Co-Infection: Metagenomic Analysis During Infection and the Recovery Follow-Up

  • Anna Anselmo,
  • Fabiana Rizzo,
  • Elena Gervasi,
  • Luca Corrent,
  • Andrea Ciammaruconi,
  • Silvia Fillo,
  • Antonella Fortunato,
  • Anna Maria Marella,
  • Silvia Costantini and
  • Alessandra Ciervo
  • + 2 authors

Background: Whipple’s disease (WD) is a rare infection caused by Tropheryma whipplei. Diagnosis is challenging and requires a combination of several data sets, such as patient history, clinical and laboratory investigations, and endoscopy with...

  • Review
  • Open Access
2 Citations
4,496 Views
22 Pages

Advances in the Treatment of Enterovirus-D68 and Rhinovirus Respiratory Infections

  • Vonintsoa L. Rahajamanana,
  • Mathieu Thériault,
  • Henintsoa Rabezanahary,
  • Yesmine G. Sahnoun,
  • Maria Christina Mallet,
  • Sandra Isabel,
  • Sylvie Trottier and
  • Mariana Baz

Background/Objectives: Enterovirus-D68 (EV-D68) and rhinoviruses are major contributors to respiratory illnesses in children, presenting a spectrum of clinical manifestations ranging from asymptomatic cases to severe lower respiratory tract infection...

  • Case Report
  • Open Access
1 Citations
1,388 Views
10 Pages

The Underestimated Threat—Mycobacterium Genavense Infection: A Case Report

  • Jannik Sonnenberg,
  • Gert Gabriels,
  • Ioana Diana Olaru,
  • Sebastian Mühl,
  • Julia Fischer,
  • Hermann Pavenstädt,
  • Jonel Trebicka,
  • Kai-Henrik Peiffer and
  • Phil-Robin Tepasse

Background/Objectives: Nontuberculous mycobacteria (NTM) represent a heterogeneous group of pathogens with increasing global prevalence and significant geographical variation in species distribution. NTM infections, often affecting immunocompromised...

  • Article
  • Open Access
1,674 Views
16 Pages

Background/Objectives: COVID-19 pandemic had a significant impact on endemic respiratory illnesses. Through behavioral changes in populations and government policy, mainly through non-pharmaceutical interventions (NPIs), Canada saw historic lows in t...

  • Case Report
  • Open Access
1,259 Views
10 Pages

Vasculonecrotic Reaction Caused by Mycobacterium Lepromatosis Infection—A Case Report of an HIV/Leprosy-Coinfected Patient

  • Fernando Amador-Lara,
  • Jorge L. Mayorga-Garibaldi,
  • Felipe J. Bustos-Rodríguez,
  • Luz A. González-Hernández,
  • Pedro Martínez-Ayala and
  • Jaime F. Andrade-Villanueva

Background: Vasculonecrotic reactions in leprosy are typically associated with type 2 reactions. Differentiating between necrotizing erythema nodosum leprosum (nENL) and Lucio’s phenomenon (LP) can be difficult, as overlapping clinical and hist...

  • Review
  • Open Access
1,264 Views
11 Pages

Spatial, Social and Serological Factors in the Prevalence and Risk of Leprosy in Areas of High Endemicity: An Integrative Review

  • Daniele dos Santos Lages,
  • Isabela Cristina Lana Maciel,
  • Sarah Lamas Vidal and
  • Francisco Carlos Félix Lana

Background/Objectives: Leprosy remains a global public health challenge, especially in hyperendemic areas, where spatial, socioeconomic and serological factors influence its persistence. In this study, an integrative review was carried out to analyze...

  • Systematic Review
  • Open Access
4 Citations
7,667 Views
24 Pages

Background: Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, long COVID (LC) has become a significant global health burden. While knowledge about LC is accumulating, studies on its prevention are s...

  • Systematic Review
  • Open Access
2 Citations
1,315 Views
12 Pages

The Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker of Fournier’s Gangrene Severity: A Meta-Analysis

  • Konstantinos Seretis,
  • Nikolaos Bounas,
  • Konstantinos Sfaelos,
  • Georgios Gaitanis and
  • Ioannis Bassukas

Background/Objectives: Fournier’s Gangrene (FG) is a severe and potentially fatal necrotizing infection of the perianal and genital regions, which necessitates prompt therapeutic interventions to prevent disease progression. Accruing evidence f...

  • Article
  • Open Access
1,517 Views
13 Pages

The PJI-TNM Classification as Predictor for Revision-Free Implant Survival Rates in Patients with Periprosthetic Joint Infection of the Hip or Knee Joint

  • Frank Sebastian Fröschen,
  • Lisa Greber,
  • Ernst Molitor,
  • Gunnar Thorben Rembert Hischebeth,
  • Alexander Franz and
  • Thomas Martin Randau

Background: Periprosthetic joint infections (PJIs) remain a major challenge in arthroplasty. This study tries to evaluate the PJI-TNM classification as predictor for the revision-free implant survival in patients with PJI of the hip or knee joint. Me...

  • Case Report
  • Open Access
1 Citations
1,675 Views
9 Pages

A Case of Pulmonary Fibrosis and COVID-19-Related Pneumonia in a Pembrolizumab-Treated Patient

  • Alberto Zolezzi,
  • Gina Gualano,
  • Annelisa Mastrobattista,
  • Pietro Vittozzi,
  • Virginia Di Bari,
  • Carlotta Cerva,
  • Silvia Mosti,
  • Antonio Lugini,
  • Fabrizio Albarello and
  • Fabrizio Palmieri
  • + 2 authors

Pembrolizumab is used as a first-line treatment of non-small cell lung cancer. Pneumonitis and interstitial lung disease are among the most common immune-related adverse events. The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...

  • Article
  • Open Access
1 Citations
1,530 Views
13 Pages

Delineating the Significance of Several Inflammatory Markers in a Lung Tuberculosis Cohort During the Active and Post-Tuberculosis Stages of the Disease: An Observational Study in Cape Town, South Africa (2019 to 2024)

  • Chrisstoffel Jumaar,
  • Lindiwe Malefane,
  • Steve Jacobs,
  • Olakunle Sanni,
  • Elize Louw,
  • Nicola Baines,
  • Carmen Payne,
  • Sigrid Schulz,
  • Carl Lombard and
  • Gerald J. Maarman
  • + 6 authors

Background: Pulmonary tuberculosis (TB) frequently leads to long-term lung complications that contribute to increased mortality. Understanding the pathogenesis of post-TB lung impairments is crucial for improving long-term outcomes in TB patients; ye...

  • Article
  • Open Access
1 Citations
1,139 Views
13 Pages

Stage-Specific Immune Responses to AgB T-Peptides in Patients with Cystic Echinococcosis

  • Settimia Sbarra,
  • Ambra Vola,
  • Francesca Tamarozzi,
  • Saeid Najafi-Fard,
  • Alessandra Ludovisi,
  • Antonella Teggi,
  • Emanuele Nicastri,
  • Fabrizio Albarello,
  • Enrico Brunetti and
  • Linda Petrone
  • + 1 author

Background: The identification of parasite- and stage-specific antigens is crucial for the development of new diagnostic tests for cystic echinococcosis (CE). We previously analysed the interleukin (IL)-4 response to T-specific peptides corresponding...

  • Article
  • Open Access
1 Citations
1,243 Views
15 Pages

Exploring the Antibiotic Potential of a Serine Protease from Solanum trilobatum Against Staphylococcus aureus Biofilms

  • Manohar Radhakrishnan,
  • Kanal Elamparithi Balu,
  • Lakshminarayanan Karthik,
  • Raghavendra Sashi Krishna Nagampalli,
  • Eswar Kumar Nadendla and
  • Gunasekaran Krishnasamy

Background: Multi-antibiotic resistance has become an alarming issue in treating bacterial infections in both community and medical environments. Globally, the scientific community has been exploring multi-antibiotic techniques to find new ways to ad...

  • Article
  • Open Access
1,406 Views
15 Pages

Microbiological Surveillance and Antimicrobial Susceptibility Observations on Peritoneal Dialysis-Associated Peritonitis in an Outpatient German Reference Center

  • Annemarie Albert,
  • Stefan Richter,
  • Lisa C. Costello-Boerrigter,
  • Philipp Stieger,
  • Rainer Peter Woitas,
  • Rüdiger C. Braun-Dullaeus and
  • Christian Albert

Background: Peritonitis is a relevant complication in peritoneal dialysis (PD). The initial empirical antibiotic therapy depends on the center-specific distribution of microorganisms and the microbial susceptibility profiles. However, data on the loc...

  • Article
  • Open Access
1 Citations
1,948 Views
11 Pages

Prevalence of VZV Reactivation and Effectiveness of Vaccination with Recombinant Adjuvanted Zoster Vaccine in Allogeneic Hematopoietic Stem Cell Recipients—A Single-Center Analysis

  • Ewa Karakulska-Prystupiuk,
  • Magdalena Feliksbrot-Bratosiewicz,
  • Maria Król,
  • Agnieszka Tomaszewska,
  • Wiesław Wiktor Jędrzejczak and
  • Grzegorz Władysław Basak

Background: Secondary immunodeficiencies in allo-HSCT (allogeneic hematopoietic stem cell transplantation) recipients increase the risk of viral reactivation, making vaccinations a vital issue. There is a paucity of data on the use of recombinant vac...

  • Case Report
  • Open Access
1,873 Views
15 Pages

Bone Marrow Infection by Pneumocystis jirovecii in a Patient with AIDS: A Case Report and Literature Review

  • Diego Alejandro Cubides-Diaz,
  • Valentina Negrette-Lazaro,
  • Viviana Poveda-Hurtado,
  • Juan Pablo López-Salazar,
  • Carlos Mauricio Calderón-Vargas and
  • Carlos Arturo Álvarez-Moreno

Background: Pneumocystis jirovecii primarily causes pneumonia in immunosuppressed individuals, particularly those living with advanced HIV/AIDS. Extrapulmonary dissemination is uncommon, with bone marrow involvement described in only a handful of cas...

  • Case Report
  • Open Access
1,447 Views
7 Pages

The Appearance of Osteomyelitis of the Foot and Disseminated Subcutaneous Abscesses During Treatment for Disseminated Tuberculosis Infection in an Immunocompetent Patient: Case Presentation of a Paradoxical Reaction and Literature Review

  • Luca Santilli,
  • Benedetta Canovari,
  • Maria Balducci,
  • Francesco Ginevri,
  • Monia Maracci,
  • Antonio Polenta,
  • Norma Anzalone,
  • Lucia Franca,
  • Beatrice Mariotti and
  • Francesco Barchiesi
  • + 1 author

Background: The appearance of new clinical manifestations (for example, subcutaneous or skin abscesses) during anti-tuberculosis treatment is generally indicative of therapeutic failure. The cause of therapeutic failure may be the presence of a drug-...

  • Case Report
  • Open Access
1,301 Views
8 Pages

Introduction: Spotted fever group (SFG) rickettsioses are tick-transmitted infections caused by Gram-negative, obligately intracellular bacteria in the genus Rickettsia. They present as an acute undifferentiated febrile illness, and they are often ac...

  • Article
  • Open Access
3 Citations
2,115 Views
11 Pages

Background. Sudan virus (SUDV) has caused multiple outbreaks in Uganda over the past two decades, leading to significant morbidity and mortality. The recent outbreaks in 2022 and 2025 highlight the ongoing threat posed by SUDV and the challenges in i...

  • Article
  • Open Access
1 Citations
1,426 Views
8 Pages

Incidence of COVID-19 Symptom Rebound After Treatment with Remdesivir

  • Kalpana Gupta,
  • William J. O’Brien,
  • Judith Strymish,
  • Anna Chen,
  • Katherine Linsenmeyer,
  • Rebecca Madjarov and
  • Michael E. Charness

Background/Objectives: Recent in vitro data suggest that remdesivir might be less likely than nirmatrelvir–ritonavir to be associated with COVID-19 rebound. We compared the incidence of symptom rebound in our remdesivir-treated cohort with rate...

  • Brief Report
  • Open Access
1,553 Views
10 Pages

Humoral and Cell-Mediated Immunity Against SARS-CoV-2 in Healthcare Personnel Who Received Multiple mRNA Vaccines: A 4-Year Observational Study

  • Hideaki Kato,
  • Kaori Sano,
  • Kei Miyakawa,
  • Takayuki Kurosawa,
  • Kazuo Horikawa,
  • Yayoi Kimura,
  • Atsushi Goto and
  • Akihide Ryo

Background/Objectives: The long-term effects of multiple updated vaccinations against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have not been clarified. Humoral or cellular immunity dynamics in healthcare workers for four years wer...

  • Article
  • Open Access
1 Citations
3,085 Views
11 Pages

Analysis of Factors Determining Serologic Response to Treatment of Early Syphilis in Adult Men

  • Justyna Czarny,
  • Damian Kadylak,
  • Małgorzata Sokołowska-Wojdyło and
  • Roman J. Nowicki

Background: Syphilis is an infectious systemic disease that remains a public health threat, with an increasing incidence worldwide. Despite the availability of diagnostic tests and effective treatments, achieving a serological cure remains challengin...

  • Review
  • Open Access
2,712 Views
12 Pages

Treatment of Condyloma Acuminata with Tirbanibulin 1% Ointment in People Living with HIV: A Case Series with Literature Review

  • Fabio Artosi,
  • Terenzio Cosio,
  • Lorenzo Ansaldo,
  • Alessandro Cavasio,
  • Loredana Sarmati,
  • Luca Bianchi and
  • Elena Campione

Background: Condyloma acuminata (CA) are dysplastic lesions caused by human papillomavirus (HPV) infection. Condylomata acuminata are common in Human Immunodeficiency Virus- (HIV) infected individuals and have been linked to HIV transmission. Current...

  • Article
  • Open Access
3 Citations
2,144 Views
13 Pages

Diagnostic Challenges in Extrapulmonary Tuberculosis: A Single-Center Experience in a High-Resource Setting at a German Tertiary Care Center

  • Jonas Wilmink,
  • Richard Vollenberg,
  • Ioana D. Olaru,
  • Julia Fischer,
  • Jonel Trebicka and
  • Phil-Robin Tepasse

Background/Objectives: Extrapulmonary tuberculosis accounts for a significant portion of tuberculosis cases, presenting unique diagnostic challenges due to its heterogeneous manifestations and paucibacillary nature. This study aims to fill this gap b...

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Infect. Dis. Rep. - ISSN 2036-7449