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Infectious Disease Reports, Volume 17, Issue 4

August 2025 - 30 articles

Cover Story: Researchers have identified a gene activity pattern linked to type I interferons (IFNs) in active tuberculosis (TB), suggesting their role in the disease’s development. Health issues like HIV, diabetes, lupus, severe kidney disease, and COVID-19 can increase the risk of dormant TB progressing to active disease. Interestingly, type I IFNs are also involved in these health conditions, sharing similar gene activity patterns. This review summarizes existing studies on the role of type I IFNs in TB disease progression and highlights potential links among these health issues that share similar immune dysfunctions. Understanding these connections is key to developing treatments that target the immune system and improving tests for TB diagnosis. View this paper
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Articles (30)

  • Article
  • Open Access
2,758 Views
11 Pages

Dressing Impregnated with Chlorhexidine and Vancomycin for the Prophylaxis of Central Venous Catheter-Related Infections—A Randomized Trial

  • Giovanna Cerri Lessa,
  • Carolina Comitti Zanella,
  • Gustavo Pessatto Krause,
  • Alexandre Moreira Senter,
  • Paula Hansen Suss,
  • Gabriel Burato Ortis,
  • Thyago Proenca de Moraes and
  • Felipe Francisco Tuon

Background: Central venous catheters (CVCs) are essential in intensive care units (ICUs) for monitoring and administering treatments; however, catheter-related bloodstream infections (CRBSIs) are significant complications, leading to severe outcomes...

  • Article
  • Open Access
701 Views
18 Pages

The Role of Nutritional Environment in Cryptococcus gattii Titan Cells’ Ultrastructure, Biophysical Properties, Molecular Features, and Virulence in Cryptococcosis

  • Igor Avellar-Moura,
  • Glauber R. de S. Araujo,
  • Juliana Godoy,
  • Vinicius Alves,
  • Iara Bastos de Andrade,
  • Juliana Soares,
  • Bruno Pontes and
  • Susana Frases

Background/Objectives: Cryptococcus gattii presents a significant threat to healthy individuals. Titan cell formation, a key virulence factor, is influenced by the nutritional environment and plays a critical role in immune evasion and stress resista...

  • Article
  • Open Access
774 Views
15 Pages

Epstein–Barr Virus Detection in Lymphoproliferative Disorders: Epidemiological Characterization in Western Mexico

  • Karel Cesar Licona-Lasteros,
  • Eduardo Navarrete-Medina,
  • Karina Franco-Topete,
  • Sergio Yair Rodriguez-Preciado,
  • Jaime Palomares-Marin,
  • Gerardo Cazarez-Navarro,
  • Ramón Antonio Franco-Topete and
  • Iván Isidro Hernández-Cañaveral

Background/Objectives: Epstein–Barr virus (EBV) detection patterns in lymphoproliferative disorders (LPDs) show significant geographical variation worldwide. Regional epidemiological data are essential for understanding viral distribution patte...

  • Article
  • Open Access
1,270 Views
14 Pages

Spatiotemporal Dynamics of Dengue in the State of Pará and the Socio-Environmental Determinants in Eastern Brazilian Amazon

  • Brenda Caroline Sampaio da Silva,
  • Ricardo José de Paula Souza e Guimarães,
  • Bruno Spacek Godoy,
  • Andressa Tavares Parente,
  • Bergson Cavalcanti de Moraes,
  • Marcia Aparecida da Silva Pimentel,
  • Douglas Batista da Silva Ferreira,
  • Emilene Monteiro Furtado Serra,
  • João de Athaydes Silva Junior and
  • Luciano Jorge Serejo dos Anjos
  • + 1 author

Background: The Amazon biome exhibits complex arboviral transmission dynamics influenced by accelerating deforestation, climate change, and socioeconomic inequities. Objectives/Methods: This study integrates official epidemiological records with soci...

  • Article
  • Open Access
978 Views
11 Pages

Antimicrobial Effect of Gentamicin/Heparin and Gentamicin/Citrate Lock Solutions on Staphylococcus aureus and Pseudomonas aeruginosa Clinical Strains

  • Daniel Salas-Treviño,
  • Arantxa N. Rodríguez-Rodríguez,
  • María T. Ramírez-Elizondo,
  • Magaly Padilla-Orozco,
  • Edeer I. Montoya-Hinojosa,
  • Paola Bocanegra-Ibarias,
  • Samantha Flores-Treviño and
  • Adrián Camacho-Ortiz

Background/Objectives: Hemodialysis catheter-related bloodstream infection (HD-CRBSIs) is a main cause of morbidity in hemodialysis. New preventive strategies have emerged, such as using lock solutions with antiseptic or antibiotic capacity. In this...

  • Article
  • Open Access
639 Views
18 Pages

Biocide Tolerance, Biofilm Formation, and Efflux Pump Activity in Clinical Isolates of Trichosporon asahii

  • Yasmim Passos Lima,
  • Jamile de Paiva Macedo,
  • Alessandra Barbosa Ferreira Machado,
  • Cláudio Galuppo Diniz,
  • Vania Lucia da Silva and
  • Vanessa Cordeiro Dias

Background: Trichosporon spp. are opportunistic fungi, capable of causing infection, especially in critically ill individuals who often use broad-spectrum antibiotics, invasive devices, and have comorbidities. Objectives The aim of this study was to...

  • Case Report
  • Open Access
1,677 Views
9 Pages

Scrofuloderma, an Old Acquaintance: A Case Report and Literature Review

  • Heiler Lozada-Ramos and
  • Jorge Enrique Daza-Arana

Scrofuloderma, a cutaneous manifestation of tuberculosis, is a rare but clinically significant form of mycobacterial infection. It typically results from the local spread of Mycobacterium tuberculosis from an infected lymph node or bone area to the o...

  • Article
  • Open Access
693 Views
11 Pages

Cognitive Screening with the Italian International HIV Dementia Scale in People Living with HIV: A Cross-Sectional Study in the cART Era

  • Maristella Belfiori,
  • Francesco Salis,
  • Sergio Angioni,
  • Claudia Bonalumi,
  • Diva Cabeccia,
  • Camilla Onnis,
  • Nicola Pirisi,
  • Francesco Ortu,
  • Paola Piano and
  • Stefano Del Giacco
  • + 1 author

Background: HIV-associated neurocognitive disorders (HANDs) continue to be a significant concern, despite the advancements in prognosis achieved through Combination Antiretroviral Therapy (cART). Neuropsychological assessment, recommended by internat...

  • Case Report
  • Open Access
1,135 Views
8 Pages

The First Schaalia (Formerly Actinomyces) Canis-Related Osteomyelitis Requiring Surgical Intervention

  • Patrick Nugraha,
  • Tzong-Yang Pan,
  • Paul Di Giovine,
  • Nigel Mann and
  • William Murphy

Schaalia canis is a Gram-positive, facultatively anaerobic, rod-shaped bacterium originally isolated from the mucosa and skin of dogs. While it is a part of the normal canine oral flora, it has rarely been implicated in human disease, with only one p...

  • Article
  • Open Access
789 Views
12 Pages

Detection of Microorganisms Causing Human Respiratory Infection Using One-Tube Multiplex PCR

  • Isabela L. Lima,
  • Adriana F. Neves,
  • Robson J. Oliveira-Júnior,
  • Lorrayne C. M. G. Honório,
  • Vitória O. Arruda,
  • Juliana A. São Julião,
  • Luiz Ricardo Goulart Filho and
  • Vivian Alonso-Goulart

Background/Objectives: Due to the significant overlap in symptoms between COVID-19 and other respiratory infections, a multiplex PCR-based platform was developed to simultaneously detect 22 respiratory pathogens. Target sequences were retrieved from...

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Infect. Dis. Rep. - ISSN 2036-7449