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Pharmaceutics, Volume 11, Issue 8 (August 2019)
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Cover Story (view full-size image) The encapsulation of flavonoids into lipid nanoemulsions (LN) overcomes their limitations, such as [...] Read more. The encapsulation of flavonoids into lipid nanoemulsions (LN) overcomes their limitations, such as reduced hydrosolubility and bioavailability, which restrict their therapeutic use as anti-inflammatory compounds. Endothelium-targeted LN can be obtained by coupling targeting moieties, able to recognize a specific molecule expressed on activated endothelial cells (EC) (e.g., vascular cell adhesion molecule 1 (VCAM-1)), to their surface. The flavonoid-loaded LN are non-toxic and non-hemolytic and, also, exert anti-inflammatory effects as supported by functional monocyte adhesion and transmigration assays. These results open an avenue for the clinical application of polyphenol-loaded nanoparticles in the treatment of inflammation-associated diseases. View this paper