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Open AccessArticle

In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

Laboratory of Pharmaceutical Technology, Department of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
Laboratory of Physical Pharmacy, Department of Drug Science, University of Pavia, 27100 Pavia, Italy
Department of Materials Science, University of Patras, 26504 Patras, Greece
Foundation for Research and Technology Hellas, Institute of Chemical Engineering and High Temperature Chemical Processes, 26504 Patras, Greece
Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
The Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK
College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China
Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China
Nanotechnology and Integrated Bioengineering Centre, University of Ulster, Jordanstown Campus, Newtownabbey, Northern Ireland BT37 0QB, UK
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(8), 398;
Received: 17 June 2019 / Revised: 30 July 2019 / Accepted: 2 August 2019 / Published: 8 August 2019
(This article belongs to the Special Issue Buccal Drug Delivery)
In the current study, the development of mucoadhesive tablets for buccal delivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes with piroxicam and cyclodextrins (β-cyclodextrin (β-CD), methylated-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD)) were prepared by the co-evaporation method. All formulations were characterized by means of differential scanning calorimetry, infrared spectroscopy and powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by direct compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets were conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa. The results suggest that the rank order effect of cyclodextrins for the drug release was Me-β-CD > HP-β-CD > β-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly increased the transport of the drug compared to their free complexes. Finally, histological assessment revealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins. View Full-Text
Keywords: cyclodextrins; in vitro studies; ex vivo buccal permeation cyclodextrins; in vitro studies; ex vivo buccal permeation
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Kontogiannidou, E.; Ferrari, M.; Deligianni, A.-D.; Bouropoulos, N.; Andreadis, D.A.; Sorrenti, M.; Catenacci, L.; Nazari, K.; Arshad, M.S.; Chang, M.-W.; Ahmad, Z.; Fatouros, D.G. In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery. Pharmaceutics 2019, 11, 398.

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