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Open AccessArticle

Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

1
Department of Drugs Industry and Pharmaceutical Management, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania
2
University Pharmacy Department of Pharmacy Administration, Semmelweis University, H-1092 Hőgyes Endre utca 7-9, 1092 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(8), 417; https://doi.org/10.3390/pharmaceutics11080417
Received: 5 July 2019 / Revised: 2 August 2019 / Accepted: 12 August 2019 / Published: 17 August 2019
(This article belongs to the Special Issue Recent Development of Electrospinning for Drug Delivery)
Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II. Triethanolamine-containing ternary composite of aceclofenac-poly(vinyl-pyrrolidone) nanofibers were formulated to exert the synergistic effect on the drug-dissolution improvement. The composition and the electrospinning parameters were changed to select the fibrous sample of optimum fiber characteristics. To determine the morphology of the nanofibers, scanning electron microscopy was used. Fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC) were applied for the solid-state characterization of the samples, while the drug release profile was followed by the in vitro dissolution test. The nanofibrous formulations had diameters in the range of few hundred nanometers. FT-IR spectra and DSC thermograms indicated the amorphization of aceclofenac, which resulted in a rapid release of the active substance. The characteristics of the selected ternary fiber composition (10 mg/g aceclofenac, 1% w/w triethanolamine, 15% w/w PVPK90) were found to be suitable for obtaining orally dissolving webs of fast dissolution and potential oral absorption. View Full-Text
Keywords: aceclofenac; nanofiber; electrospinning; scanning electron microscopy; fourier transform infrared spectroscopy; differential scanning calorimetry aceclofenac; nanofiber; electrospinning; scanning electron microscopy; fourier transform infrared spectroscopy; differential scanning calorimetry
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MDPI and ACS Style

Sipos, E.; Kósa, N.; Kazsoki, A.; Szabó, Z.-I.; Zelkó, R. Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs. Pharmaceutics 2019, 11, 417.

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