Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs
Abstract
:1. Introduction
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- rapid disintegration and high dissolution rate in the oral cavity due to the large surface area,
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- no need of water for administration; this could be an advantage in geriatrics, pediatrics, but also for dysphagic patients or patients who are unable to swallow tablets and capsules or a large amount of water,
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- precise dosage administration in each film,
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- rapid absorption from the highly vascularized buccal mucosa—drugs are absorbed directly to the superior vena cava, entering into the systemic circulation without pre-systemic metabolism,
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2. Materials and Methods
2.1. Materials
2.2. Methods
2.2.1. Preparation of PVP Solutions Containing Aceclofenac
2.2.2. Electrospinning Process
2.2.3. Scanning Electron Microscopic Analysis (SEM)
2.2.4. Fourier-Transform Infrared (FT-IR) Spectroscopy
2.2.5. Differential Scanning Calorimetry (DSC)
2.2.6. Determination of Drug Content of Aceclofenac-Loaded Nanofibers
2.2.7. In Vitro Drug Dissolution Test
3. Results and Discussion
3.1. Morphology of the Aceclofenac-Loaded Nanofibers
3.2. FT-IR Analysis
3.3. DSC Measurements
3.4. Determination of Drug Content of Aceclofenac-Loaded Nanofibers
3.5. Dissolution Measurements of the Nanofibers
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample No. | Aceclofenac Concentration (mg/g) | PVP Concentration (w/w%) | Trolamine Concentration (w/w%) | Diameters (nm) | Predicted Tgmix (°C) |
---|---|---|---|---|---|
N1 | 10 | 13 | 1 | 435 ± 159 | 139.7 |
N2 | 10 | 15 | 1 | 596 ± 215 | 143.6 |
N3 | 10 | 17 | 1 | 1046 ± 113 | 147.1 |
N4 | 10 | 13 | 3 | 757 ± 157 | 89.9 |
N5 | 10 | 15 | 3 | 786 ± 322 * | 97.9 |
N6 | 10 | 17 | 3 | 812 ± 244 * | 104.5 |
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Sipos, E.; Kósa, N.; Kazsoki, A.; Szabó, Z.-I.; Zelkó, R. Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs. Pharmaceutics 2019, 11, 417. https://doi.org/10.3390/pharmaceutics11080417
Sipos E, Kósa N, Kazsoki A, Szabó Z-I, Zelkó R. Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs. Pharmaceutics. 2019; 11(8):417. https://doi.org/10.3390/pharmaceutics11080417
Chicago/Turabian StyleSipos, Emese, Nóra Kósa, Adrienn Kazsoki, Zoltán-István Szabó, and Romána Zelkó. 2019. "Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs" Pharmaceutics 11, no. 8: 417. https://doi.org/10.3390/pharmaceutics11080417
APA StyleSipos, E., Kósa, N., Kazsoki, A., Szabó, Z.-I., & Zelkó, R. (2019). Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs. Pharmaceutics, 11(8), 417. https://doi.org/10.3390/pharmaceutics11080417