Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Methods
2.2.1. Determination of AOR and AO
2.2.2. Aerodynamic Assessment
2.2.3. Data Processing
3. Results and Discussion
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Nebulizer | Manufacturer | Batch (S/N) | Configuration | Identification Color | |
---|---|---|---|---|---|
Pari Compact | Pari | 2W17C10078 | White | | |
Pari Compact Junior | Pari | 2W17A13163 | Light green | | |
Pari Boy SX | Pari | 2W17B01844 | Blue Pisper * | Blue | |
Red Pisper * | Red | | |||
Pari JuniorBoy SX | Pari | 2W17B08883 | Orange | | |
Pari TurboBoy SX | Pari | 2W16H00598 | Yellow | | |
Microdrop Family 2 | Flaem Nuova | 16A 155 0873 | Light blue | | |
Microdrop Calimero 2 | Flaem Nuova | 16AF450652 | Ampoule Valve MAX | Brown | |
Ampoule Valve MIN | Purple | | |||
Microdrop Pro 2 | Flaem Nuova | 15 A7870439 | Ampoule Valve MAX | Fuchsia | |
Ampoule Valve MIN | Grey | | |||
Microdrop Pro 2 Plus | Flaem Nuova | Engineering sample | Ampoule Valve MAX | Dark green | |
Ampoule Valve MIN | Pink | | |||
Omron C801KD | Omron Healthcare | 20160600989VF | Yellow-green | | |
Omron NE-C28P | Omron Healthcare | 20160905635UF | Green water | | |
Omron A3 Complete | 3A Healthcare | 201702/00279F | Ampoule Position 1 | Blush | |
Ampoule Position 3 | Lemon green | | |||
Midineb Nebby | 3A Healthcare | 16/30635 | Lilac | |
Nebulizer | Configuration | MMAD (μm) | GSD |
---|---|---|---|
Pari Compact | 3.21 ± 0.15 | 2.27 ± 0.03 | |
Pari Compact Junior | 3.38 ± 0.19 | 2.22 ± 0.01 | |
Pari Boy SX | Blue Pisper | 3.48 ± 0.09 | 2.21 ± 0.03 |
Red Pisper | 2.56 ± 0.12 | 1.99 ± 0.02 | |
Pari Junior Boy SX | 3.14 ± 0.12 | 2.10 ± 0.04 | |
Pari Turbo Boy SX | 3.67 ± 0.20 | 2.19 ± 0.05 | |
Microdrop Family 2 | 3.65 ± 0.07 | 2.12 ± 0.01 | |
Microdrop Calimero 2 | Ampoule Valve MAX | 3.28 ± 0.09 | 2.19 ± 0.03 |
Ampoule Valve MIN | 2.90 ± 0.03 | 2.22 ± 0.05 | |
Microdrop Pro 2 | Ampoule Valve MAX | 3.14 ± 0.06 | 2.10 ± 0.02 |
Ampoule Valve MIN | 2.84 ± 0.07 | 2.10 ± 0.05 | |
Microdrop Pro 2 Plus | Ampoule Valve MAX | 2.47 ± 0.09 | 2.02 ± 0.03 |
Ampoule Valve MIN | 2.14 ± 0.08 | 2.12 ± 0.02 | |
Omron C801KD | 3.25 ± 0.15 | 2.04 ± 0.02 | |
Omron NE-C28P | 3.63 ± 0.12 | 2.05 ± 0.03 | |
Omron A3 Complete | Ampoule Position 1 | 6.76 ± 0.16 | 2.54 ± 0.02 |
Ampoule Position 3 | 4.44 ± 0.06 | 2.12 ± 0.03 | |
Midineb Nebby | 4.97 ± 0.01 | 2.16 ± 0.03 |
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Adorni, G.; Seifert, G.; Buttini, F.; Colombo, G.; Stecanella, L.A.; Krämer, I.; Rossi, A. Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects. Pharmaceutics 2019, 11, 406. https://doi.org/10.3390/pharmaceutics11080406
Adorni G, Seifert G, Buttini F, Colombo G, Stecanella LA, Krämer I, Rossi A. Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects. Pharmaceutics. 2019; 11(8):406. https://doi.org/10.3390/pharmaceutics11080406
Chicago/Turabian StyleAdorni, Greta, Gerrit Seifert, Francesca Buttini, Gaia Colombo, Luciano A. Stecanella, Irene Krämer, and Alessandra Rossi. 2019. "Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects" Pharmaceutics 11, no. 8: 406. https://doi.org/10.3390/pharmaceutics11080406
APA StyleAdorni, G., Seifert, G., Buttini, F., Colombo, G., Stecanella, L. A., Krämer, I., & Rossi, A. (2019). Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects. Pharmaceutics, 11(8), 406. https://doi.org/10.3390/pharmaceutics11080406