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Pharmaceutics, Volume 11, Issue 9 (September 2019)
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Cover Story (view full-size image) The rapid increase of antimicrobial resistance has made it imperative to develop alternative [...] Read more. The rapid increase of antimicrobial resistance has made it imperative to develop alternative therapeutic strategies for bacterial infection. A novel chemo-photothermal combinational system was thus constructed based on porous carrier zeolitic imidazolate frameworks-8 (ZIF-8) and the photothermal agent indocyanine green (ICG). Zn2+ ions released from ZIF-8 greatly enhanced the photothermal bactericidal efficacy by inhibiting bacterial growth and reducing the heat resistance of bacteria. In vivo animal experiments demonstrated that this system exhibited a nearly 100% bactericidal ratio against methicillin-resistant Staphylococcus aureus infection. Therefore, the chemo-photothermal combinational system was considered an effective weapon in combating multidrug-resistant bacteria. View this paper.