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Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

1
ENSAIT, GEMTEX—Laboratoire de Génie et Matériaux Textiles, F-59000 Lille, France
2
Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino (TO), Italy
3
College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China
4
Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Torino, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(8), 403; https://doi.org/10.3390/pharmaceutics11080403
Received: 30 June 2019 / Revised: 30 July 2019 / Accepted: 5 August 2019 / Published: 11 August 2019
(This article belongs to the Special Issue Transdermal Drug Delivery Systems)
PDF [2164 KB, uploaded 21 August 2019]
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Abstract

In the field of pharmaceutical technology, significant attention has been paid on exploiting skin as a drug administration route. Considering the structural and chemical complexity of the skin barrier, many research works focused on developing an innovative way to enhance skin drug permeation. In this context, a new class of materials called bio-functional textiles has been developed. Such materials consist of the combination of advanced pharmaceutical carriers with textile materials. Therefore, they own the possibility of providing a wearable platform for continuous and controlled drug release. Notwithstanding the great potential of these materials, their large-scale application still faces some challenges. The present review provides a state-of-the-art perspective on the bio-functional textile technology analyzing the several issues involved. Firstly, the skin physiology, together with the dermatological delivery strategy, is keenly described in order to provide an overview of the problems tackled by bio-functional textiles technology. Secondly, an overview of the main dermatological nanocarriers is provided; thereafter the application of these nanomaterial to textiles is presented. Finally, the bio-functional textile technology is framed in the context of the different dermatological administration strategies; a comparative analysis that also considers how pharmaceutical regulation is conducted.
Keywords: textiles; biomedical materials; regulatory issues; skin; transdermal drug delivery; nanocarriers; electrospinning; encapsulation; fibers textiles; biomedical materials; regulatory issues; skin; transdermal drug delivery; nanocarriers; electrospinning; encapsulation; fibers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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MDPI and ACS Style

Massella, D.; Argenziano, M.; Ferri, A.; Guan, J.; Giraud, S.; Cavalli, R.; Barresi, A.A.; Salaün, F. Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies. Pharmaceutics 2019, 11, 403.

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