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Viruses, Volume 18, Issue 7

2026 July - 116 articles

Cover Story: Cytosolic DNA generated during viral infection or cellular damage activates the cGAS-STING pathway, driving interferon and inflammatory cytokine production. Our study identifies G3BP1, a key stress-granule protein, as a regulator of DNA sensing at multiple levels. Using cytosolic dsDNA and HSV-1 infection, we show that G3BP1 promotes STING trafficking from the endoplasmic reticulum to the Golgi and supports downstream interferon, cytokine, PERK, and stress-granule responses. Loss of G3BP1 disrupts these processes even when STING is directly activated by cGAMP, revealing a previously unrecognized role downstream of cGAS. These findings establish the STING-PERK-G3BP1 axis as a link between innate immunity and cellular stress signaling, with implications for antiviral defense and diseases involving aberrant DNA sensing. View this paper
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Articles (116)

  • Article
  • Open Access
703 Views
26 Pages

Comparative Genomic Analysis of Two Bat Poxviruses in the Genus Vespertilionpoxvirus

  • Chi Zhang,
  • Kyle Heye,
  • Davide Lelli,
  • Loubna Tazi and
  • Stefan Rothenburg

26 June 2026

Poxviruses are large double-stranded DNA (dsDNA) viruses that cause important human and animal diseases, including smallpox and mpox. Poxviruses have also been identified in diverse bat populations; however, their potential for zoonotic transmission...

(This article belongs to the Special Issue Animal Virus Discovery and Genetic Diversity: 2nd Edition)
  • Article
  • Open Access
2 Citations
723 Views
24 Pages

Genetic and Antigenic Characterization of Bovine and Porcine Respiratory Coronaviruses Circulating in Western Europe, 2020–2023

  • Ruth M. Mumo,
  • Anna Parys,
  • Sieglinde Coppens,
  • Nick Vereecke,
  • Sebastiaan Theuns,
  • Bart Pardon and
  • Kristien Van Reeth

26 June 2026

The 2019 coronavirus disease pandemic (COVID-19) showed how genetic mutations can alter coronavirus characteristics. However, the evolution of livestock coronaviruses remains understudied. We analyzed 15 bovine coronavirus (BCoV), three porcine hemag...

(This article belongs to the Section Coronaviruses)
  • Article
  • Open Access
731 Views
11 Pages

Read-Level Error Characterization of Rolling-Circle Amplification-Based Nanopore Sequencing of the Circular DNA Virome

  • Florencia Martino,
  • Kakhangchung Panmei,
  • Dylan Duchen,
  • David L. Thomas,
  • Abraham J. Kandathil and
  • Steven J. Clipman

26 June 2026

Oxford Nanopore technology enables cost-effective, portable, long-read analyses of pathogen genomes. Accurate detection and interpretation of small circular viral genomes, including Anelloviridae, remain challenging due to limited base-level error qu...

(This article belongs to the Special Issue Advancing Research of Anelloviruses, Second Edition)
  • Article
  • Open Access
724 Views
27 Pages

HIV-V3Augur: A Novel Machine Learning Model for Predicting HIV-1 Tropism in Sub-Subtype A6 and CRF63_02A6, Predominant Variants in Russia and Countries of the Former Soviet Union

  • Kirill Elfimov,
  • Ludmila Gotfrid,
  • Alina Nokhova,
  • Mariya Gashnikova,
  • Vasiliy Ekushov,
  • Maksim Halikov,
  • Irina Osipova,
  • Dmitriy Baboshko,
  • Andrey Murzin and
  • Natalya Gashnikova
  • + 4 authors

25 June 2026

Determining HIV-1 tropism provides the prognosis of HIV infection and is required before prescribing maraviroc, an entry inhibitor that blocks the interaction between the viral gp120 and the CCR5 coreceptor. However, existing prediction algorithms ha...

(This article belongs to the Special Issue Immunity in Persistent Viral Infection and AI Guided Antiviral Drug Design)
  • Review
  • Open Access
729 Views
17 Pages

25 June 2026

Avian viruses formed the foundation of early retrovirology. The historical line extends from the discovery of the first sarcoma virus by Peyton Rous to the quantitative determination of oncogenic activity in cell culture by the focus assay. As a vira...

(This article belongs to the Section General Virology)
  • Article
  • Open Access
607 Views
13 Pages

Non-Canonical Binding of Nelfinavir in HIV-1 Protease Variants Reveals Structural Mechanisms of Antiretroviral Resistance

  • Christian Cadena-Cruz,
  • Marcio De Avila-Arias,
  • Fabio Guzmán,
  • Mariana Pérez,
  • María Angelica Zuluaga,
  • Elkin Navarro Quiroz,
  • Alejandro Angulo,
  • Luz Elena Prieto Garcerant,
  • Hector Rodríguez Rojas and
  • Jose Luis Villarreal-Camacho
  • + 2 authors

25 June 2026

Background: Antiretroviral resistance-associated mutations, within the broader context of HIV-1 genetic variability, represent a growing challenge for HIV-1 control, highlighting the need for continuous molecular surveillance and mechanistic understa...

(This article belongs to the Section General Virology)
  • Article
  • Open Access
1 Citations
866 Views
13 Pages

Involvement of 5′ and 3′ UTRs in SARS-CoV-2 Virus-like Particle Genome Packaging

  • Zhang Zhang,
  • Kun Yang,
  • Fangze Shao,
  • Wenlong Shen,
  • Ping Li,
  • Yue Zhang,
  • Junjie Xu,
  • Dejian Xie,
  • Chudong Wang and
  • Yan Zhang
  • + 3 authors

25 June 2026

The molecular mechanisms governing the efficient packaging of the large SARS-CoV-2 RNA genome into progeny virions remain incompletely understood, with the role of untranslated regions (UTRs) being particularly enigmatic. Leveraging proximity ligatio...

(This article belongs to the Special Issue Coronaviruses: Variants, Antivirals, and Vaccination)
  • Systematic Review
  • Open Access
1 Citations
1,034 Views
28 Pages

Person-to-Person Transmission of Andes Virus (ANDV): A Systematic Review of Transmission Dynamics, Viral Shedding, and Public Health Implications

  • Flavia Pennisi,
  • Antonio Pinto,
  • Stefania Borlini,
  • Sabrina Caruccio,
  • Giusy D’Alterio,
  • Carlo Signorelli and
  • Giovanni Rezza

25 June 2026

Andes virus (ANDV) is the only hantavirus with well-documented evidence of person-to-person transmission. However, key parameters related to transmission timing, viral shedding, exposure contexts, and public health management remain incompletely defi...

(This article belongs to the Special Issue High Consequence Viral Transmission)
  • Article
  • Open Access
534 Views
8 Pages

25 June 2026

While minimalist kinetic models effectively capture the acute inverse coupling between Hepatitis B (HBV) and Hepatitis Delta (HDV), they often fail to account for the asymptotic stability and long-term viral plateaus observed during clinical therapy....

(This article belongs to the Section General Virology)
  • Article
  • Open Access
581 Views
14 Pages

P. hybridus Extract Ze 339 Inhibits RSV Infection by Altering Host Metabolism

  • Fabian Otte,
  • Verena M. Merk,
  • Georg Boonen,
  • Thomas Klimkait,
  • Veronika Butterweck and
  • David Hauser

24 June 2026

Respiratory syncytial virus (RSV) remains a major cause of severe respiratory disease worldwide, particularly affecting young children and immunocompromised individuals, highlighting the need for additional therapeutic strategies. In this study, the...

(This article belongs to the Section Viral Immunology, Vaccines, and Antivirals)
  • Article
  • Open Access
531 Views
13 Pages

Differential Binding and Neutralising Antibody Responses Across COVID-19 Severity in a Saudi Multicentre Cohort

  • Mariam M. AlEissa,
  • Nada Saleh,
  • Ahdab A. Alsaieedi,
  • Raghad A. AlQurashi,
  • Esraa A. Hawsa,
  • Muath ben Shaded,
  • Amer M. Alshehri,
  • Eyad Y. Abu Sarhan,
  • Osamah T. Khojah and
  • Abdullah M. Assiri
  • + 9 authors

24 June 2026

Background: Humoral immune responses to SARS-CoV-2 are well documented, yet the immunopathogenic mechanisms distinguishing severe from critical disease remain incompletely defined, particularly in Middle Eastern populations. We investigated antibody...

(This article belongs to the Special Issue COVID-19 Complications and Co-Infections: 2nd Edition)
  • Review
  • Open Access
627 Views
19 Pages

From Pollen to Pathogen Defense: How Pollen Chemical Quality Impacts Deformed Wing Virus Infection and Survival in Honey Bees

  • Richard García Domínguez,
  • María D. López-Belchí,
  • Nolberto Arismendi and
  • Marisol Vargas

24 June 2026

Pollen constitutes the primary source of proteins, amino acids, lipids, sterols, vitamins, and minerals for honey bees. However, not all pollen types provide the same resources or have the same biological value. Its chemical composition changes accor...

(This article belongs to the Section Invertebrate Viruses)
  • Article
  • Open Access
653 Views
12 Pages

Development and Validation of a Rapid Titer Assay for the Oncolytic Virus oHSV2 Expressing a PD-L1/CD3 Bispecific Antibody

  • Shengjie Zhang,
  • Qingrui Song,
  • Runyang Wang,
  • Rui Chen,
  • Han Hu,
  • Binlei Liu and
  • Yang Wang

24 June 2026

Oncolytic viruses represent a promising class of anticancer therapeutics, and rapid, accurate quantification of viral titers is critical for ensuring both efficacy and safety during clinical development. Conventional viral titering methods, such as 5...

(This article belongs to the Section Human Virology and Viral Diseases)
  • Article
  • Open Access
486 Views
14 Pages

First Report of Porcine Bocavirus and Porcine Cytomegalovirus in Croatian ASF-Negative Wild Boar Populations

  • Jelena Prpić,
  • Magda Kamber Taslaman,
  • Margarita Božiković,
  • Daria Jurković Žilić,
  • Andreja Jungić,
  • Ivana Lojkić and
  • Lorena Jemeršić

23 June 2026

Wild boar populations are increasingly recognized as important hosts in the ecology of swine viruses, yet data from Croatia remain limited. This study aimed to establish baseline information on the presence of porcine bocavirus (PBoV) and porcine cyt...

(This article belongs to the Special Issue Spotlight on Bocavirus and Other Parvoviruses, and Overlooked Respiratory Viruses)
  • Review
  • Open Access
2,969 Views
25 Pages

Eastern Equine Encephalitis Virus Complex: Human Disease, Diagnosis and Treatment

  • Mohammed Umar,
  • Evan P. Williams,
  • Gabriel Correa Quitete Schaller Chagas,
  • Anuj Singh,
  • Katarina Rueda and
  • Colleen B. Jonsson

23 June 2026

The Eastern equine encephalitis virus (EEEV) complex comprises mosquito-borne neurotropic alphaviruses maintained in nature by mosquitoes. Although rare, human infections caused by these viruses can lead to febrile illness that may progress to severe...

(This article belongs to the Special Issue Mosquito-Borne Encephalitis Viruses: 2nd Edition)
  • Article
  • Open Access
581 Views
9 Pages

Influenza as the Predominant Cause of Severe Hepatic Involvement in Children Hospitalized with Acute Respiratory Infections: A Post-COVID-19 Era Analysis

  • Ozlem Kalaycik Sengul,
  • Suleyman Zahid Akyuz,
  • Ilke Aktas,
  • Ezgi Dilan Sencan,
  • Asude Sule Arikan,
  • Sevliya Ocal Demir and
  • Sebahat Cam

23 June 2026

Background: Following the coronavirus disease 2019 (COVID-19) pandemic, increased reports of severe acute hepatitis of unknown etiology in children have raised concerns about virus-associated liver injury. Acute respiratory tract infections (ARTIs) a...

(This article belongs to the Special Issue Extrapulmonary Manifestations of Respiratory Viruses)

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Viruses - ISSN 1999-4915